Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Abstract
Over the last era, small molecules sourced from different plants have gained attention for their varied and long‐term medicinal benefits. Their advantageous therapeutic effects in diverse pathological complications lead researchers to give an ever‐increasing emphasis on them and discover their novel therapeutic potentials. Among these, the heat stable, xanthonoid group of organic molecules has gained special importance with distinctive regards to the bioactive molecule mangiferin due to its solubility in water. Mangiferin, a yellow polyphenol having C‐glycosyl xanthone structure, is widely present in different edible sources like mango, and possesses numerous biological activities. Extensive research with this molecule shows its antioxidant, anti‐inflammatory, antidiabetic, anticancer, antimicrobial, analgesic, and immunomodulatory properties. Thus, it provides protection against a wide range of physiological disorders. The C‐glucosyl linkage and polyhydroxy groups in mangiferin's structure contribute essentially to its free radical‐scavenging activity. Moreover, its ability in regulating various transcription factors like NF‐κB, Nrf‐2, etc. and modulating the expression of different proinflammatory signaling intermediates like tumor necrosis factor‐α, COX‐2, etc. contribute to its anti‐inflammatory, anticancer, and antidiabetic potentials. In this comprehensive article, information has been provided about the sources, chemical structure, metabolism, and different biological activities of mangiferin with special emphasis on the underlying cellular signal transduction pathways. Insights into an in‐depth assessment of mangiferin's anti‐inflammatory therapeutic potential have also been discussed in detail. On an overall perspective, this review aims to stage mangiferin's diversified therapeutic applications and its emerging possibility as a promising drug in future based on its anti‐inflammatory property. © 2016 BioFactors, 42(5):459–474, 2016
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Mangiferin modulates expression of proinflammatory signaling molecules, including TNF-alpha and COX-2, and regulates transcription factors NF-κB and Nrf-2.
“Furthermore, mangiferin is capable of modulating the expression of proinflammatory signaling molecules, including the expression of TNF-α and COX-2, as well as regulating various transcription factors, such as NF-κB, and NF-E2-related factor 2 (Nrf-2) (64).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [64]
Mangiferin has antioxidant and anti-inflammatory properties due to its C-glycosylxanthone structure.
“Abundant research on the effects of mangiferin has revealed the antioxidant and anti-inflammatory properties, due to its C-glycosylxanthone structure (64).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [64]
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Mangiferin: An effective therapeutic agent against several disorders (Review)
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“Furthermore, mangiferin is capable of modulating the expression of proinflammatory signaling molecules, including the expression of TNF-α and COX-2, as well as regulating various transcription factors, such as NF-κ B, and NF-E2-related factor 2 (Nrf-2) (64).”
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Recent Formulation Advances of Mangiferin
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- Authors
- Saha, S., Sadhukhan, P., & Sil, P. C.
- Affiliations
- Bose Institute (IN)
- Corresponding author
- Sil, Parames C.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2016-05-24
- Volume
- 42
- Issue
- 5
- Pages
- 459-474
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2405052429
- Semantic Scholar
- 020c0fb54cf134870d9d4d28b64c1d585c5e8017
- Cited by
- 159
- References
- 160
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 15 · 2023: 19 · 2022: 23 · 2021: 21 · 2020: 16 · 2019: 11 · 2018: 14 · 2017: 7 · 2016: 2
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- mangiferin, xanthones, anti-inflammatory activity, antioxidant activity, mango, polyphenols, NF-κB, Nrf2, cyclooxygenase-2, TNF-α, transcription factor regulation, signaling pathways, anticancer activity, antidiabetic activity, drug development
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Humans, Plant Extracts, Xanthones
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