Cited by 159Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesBioactive natural compounds

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Saha, Sukanya, Sadhukhan, Pritam, Sil, Parames C.·2016·BioFactors

Abstract

Over the last era, small molecules sourced from different plants have gained attention for their varied and long‐term medicinal benefits. Their advantageous therapeutic effects in diverse pathological complications lead researchers to give an ever‐increasing emphasis on them and discover their novel therapeutic potentials. Among these, the heat stable, xanthonoid group of organic molecules has gained special importance with distinctive regards to the bioactive molecule mangiferin due to its solubility in water. Mangiferin, a yellow polyphenol having C‐glycosyl xanthone structure, is widely present in different edible sources like mango, and possesses numerous biological activities. Extensive research with this molecule shows its antioxidant, anti‐inflammatory, antidiabetic, anticancer, antimicrobial, analgesic, and immunomodulatory properties. Thus, it provides protection against a wide range of physiological disorders. The C‐glucosyl linkage and polyhydroxy groups in mangiferin's structure contribute essentially to its free radical‐scavenging activity. Moreover, its ability in regulating various transcription factors like NF‐κB, Nrf‐2, etc. and modulating the expression of different proinflammatory signaling intermediates like tumor necrosis factor‐α, COX‐2, etc. contribute to its anti‐inflammatory, anticancer, and antidiabetic potentials. In this comprehensive article, information has been provided about the sources, chemical structure, metabolism, and different biological activities of mangiferin with special emphasis on the underlying cellular signal transduction pathways. Insights into an in‐depth assessment of mangiferin's anti‐inflammatory therapeutic potential have also been discussed in detail. On an overall perspective, this review aims to stage mangiferin's diversified therapeutic applications and its emerging possibility as a promising drug in future based on its anti‐inflammatory property. © 2016 BioFactors, 42(5):459–474, 2016

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Crossref · 10.1002/biof.1292

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  • Mangiferin modulates expression of proinflammatory signaling molecules, including TNF-alpha and COX-2, and regulates transcription factors NF-κB and Nrf-2.

    “Furthermore, mangiferin is capable of modulating the expression of proinflammatory signaling molecules, including the expression of TNF-α and COX-2, as well as regulating various transcription factors, such as NF-κB, and NF-E2-related factor 2 (Nrf-2) (64).”
  • Mangiferin has antioxidant and anti-inflammatory properties due to its C-glycosylxanthone structure.

    “Abundant research on the effects of mangiferin has revealed the antioxidant and anti-inflammatory properties, due to its C-glycosylxanthone structure (64).”

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Research works printed but not linked: 10

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  2. Sinha K., 2013, Mangiferin, a naturally occurring xanthone C‐glycoside, ameliorates lead (Pb)‐induced murine cardiac injury via mitochondria‐dependent apoptotic pathways, Signpost Open Access J. Org. Biomol. Chem., 1, 47
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  5. Pal P. B., 2014, Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNF‐α Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin‐Induced Diabetic Rats, e107220
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Authors
Saha, S., Sadhukhan, P., & Sil, P. C.
Affiliations
Bose Institute (IN)
Corresponding author
Sil, Parames C.
Venue
BioFactors
Publisher
Wiley
Published
2016-05-24
Volume
42
Issue
5
Pages
459-474
ISSN
  • 0951-6433 (ISSN-L)
  • 1872-8081
OpenAlex
W2405052429
Cited by
159
References
160
Citations by year
2026: 13 · 2025: 17 · 2024: 15 · 2023: 19 · 2022: 23 · 2021: 21 · 2020: 16 · 2019: 11 · 2018: 14 · 2017: 7 · 2016: 2
FWCI
20.22
Type
journal article
Language
en
Open access
closed
Locations
  • BioFactors (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
mangiferin, xanthones, anti-inflammatory activity, antioxidant activity, mango, polyphenols, NF-κB, Nrf2, cyclooxygenase-2, TNF-α, transcription factor regulation, signaling pathways, anticancer activity, antidiabetic activity, drug development
MeSH terms
Animals, Anti-Inflammatory Agents, Antioxidants, Humans, Plant Extracts, Xanthones

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