The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches
Abstract
Abstract Spray drying is increasingly becoming recognized as an efficient drying and formulation technique for pharmaceutical and biopharmaceutical processing. It offers significant economic and processing advantages compared to lyophilisation/freeze‐drying techniques even though the optimisation of process parameters is often a costly and time‐consuming procedure. Spray Drying has primarily been used in formulating small molecule drugs with low solubility however it is increasingly being applied to the processing of large biomolecules and biopharmaceuticals. This review examines the basics of spray drying process, current technology and various components used in spray drying process. Moreover, it is focused on introducing critical formulation and processing factors in spray drying of small molecule drugs and large biomolecules, their similarities and differences. Finally, it provides an overview of the experimental optimisation strategies designed to achieve optimum spray drying results in the shortest possible timeframe while utilising minimum product. Graphical abstract Figure. No Caption available.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Formation of Glasses from Liquids and Biopolymers
Angell, C. A. (1995) · Science · doi:10.1126/science.267.5206.1924 · Cited by 4,799
Kamlet, M. J., Abboud, J. L. M., Abraham, M. H., & Taft, R. W. (1983) · The Journal of Organic Chemistry · doi:10.1021/jo00165a018 · Cited by 3,428
Aerosol Technology Properties, Behavior, and Measurement of Airborne Particles
LAUCKS, M. L. (2000) · Journal of Aerosol Science · doi:10.1016/s0021-8502(99)00571-6 · Cited by 3,367
Improving drug solubility for oral delivery using solid dispersions
Leuner, C. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00076-x · Cited by 2,574
Lefebvre, A. H., & McDonell, V. G. (2017) · CRC Press eBooks · doi:10.1201/9781315120911 · Cited by 2,444
Applications of spray-drying in microencapsulation of food ingredients: An overview
Gharsallaoui, A., Roudaut, G., Chambin, O., Voilley, A., & Saurel, R. (2007) · Food Research International · doi:10.1016/j.foodres.2007.07.004 · Cited by 2,422
Drug Solubility: Importance and Enhancement Techniques
Savjani, K. T., Gajjar, A. K., & Savjani, J. K. (2012) · ISRN Pharmaceutics · doi:10.5402/2012/195727 · Cited by 2,004
Pharmaceutical Applications of Solid Dispersion Systems
Chiou, W. L., & Riegelman, S. (1971) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600600902 · Cited by 1,799
Pharmaceutical Particle Engineering via Spray Drying
Vehring, R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-007-9475-1 · Cited by 1,691
Serajuddin, A. T. M. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980403l · Cited by 1,648
Cited by
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Zielińska, A., Carreiró, F., Oliveira, A. M., Neves, A., Pires, B., Venkatesh, D. N., Durazzo, A., Lucarini, M., Eder, P., Silva, A. M., et al. (2020) · Molecules · doi:10.3390/molecules25163731 · Cited by 1,560
Jakubowska, E., & Lulek, J. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102357 · Cited by 83
Metadata
- Authors
- Ziaee, A., Albadarin, A. B., Padrela, L., Femmer, T., O'Reilly, E., & Walker, G.
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 127
- Pages
- 300-318
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W2900173670
- Cited by
- 366
- References
- 106
- FWCI
- 22.64
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches. https://app.cochat.ai/papers/10.1016/j.ejps.2018.10.026
- The paper
- Ziaee, A., Albadarin, A. B., Padrela, L., Femmer, T., O'Reilly, E., & Walker, G. (2019). Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches. European Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ejps.2018.10.026
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
