Cited by 18Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery

Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis

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Teixeira, Aniely Dos Reis, Quaresma, Amanda De Vasconcelos, Branquinho, Renata Tupinambá, Santos, Stephanie Lourrani Evangelista Neves, Magalhães, Juliana Teixeira De, Silva, Fábio Henrique Rodrigues Da, Marques, Maria Betânia De Freitas, Moura, Sandra Aparecida Lima De +3 more·2023·European Journal of Pharmaceutical Sciences

Abstract

Miconazole-loaded nanoparticles coated with hyaluronic acid (miconazole-loaded nanoparticles/HA) were developed to overcome the limitations of the conventional therapy of the vulvovaginal candidiasis (VVC). They were synthesized by emulsification and solvent evaporation techniques, characterized by diameter, polydispersity index, zeta potential, encapsulation efficiency, atomic force microscopy (AFM), evaluated in terms of efficacy against C. albicans in vitro, and tested in a murine VVC model. Nanoparticles showed 211nm of diameter with a 0.32 polydispersity index, -53mV of zeta potential, and 90% miconazole encapsulation efficiency. AFM evidenced nanoparticles with a spherical shape. They inhibited the proliferation of C. albicans in vitro and in vivo after a single administration. Nanoparticles released the miconazole directly in the site of action at low therapeutic doses, which was enough to eliminate the fungal burden in the murine VVC model. These systems were rationally designed since the existence of the HA induces their adhesion on the vaginal mucus and their internalization via CD44 receptors, inhibiting the C. albicans. Therefore, miconazole-loaded nanoparticles/HA represent an innovative non-conventional pharmaceutical dosage form to treat the VVC and recurrent VVC.

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Crossref · 10.1016/j.ejps.2023.106508

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Authors
Teixeira, A. D. R., Quaresma, A. D. V., Branquinho, R. T., Santos, S. L. E. N., Magalhães, J. T. D., Silva, F. H. R. D., Marques, M. B. D. F., Moura, S. A. L. D., Barboza, A. P. M., Araújo, M. G. D. F., & Silva, G. R. D.
Affiliations
  • Universidade Federal de Ouro Preto (BR)
  • Federal University of São João del-Rei (BR)
  • Universidade Federal de Minas Gerais (BR)
Corresponding author
Silva, Gisele Rodrigues Da
Venue
European Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2023-09
Volume
188
Pages
106508
ISSN
0928-0987 (ISSN-L)
OpenAlex
W4382046051
Cited by
18
References
42
Citations by year
2026: 7 · 2025: 6 · 2024: 5
FWCI
1.96
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
Funders
  • CNPq
  • FAPEMIG
  • CAPES
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
miconazole, hyaluronic acid coating, nanoparticles, vaginal candidiasis, Candida albicans, antifungal drug delivery, CD44 targeting, emulsion solvent evaporation, encapsulation efficiency, recurrent vulvovaginal candidiasis
MeSH terms
Animals, Antifungal Agents, Candida albicans, Candidiasis, Vulvovaginal, Female, Humans, Hyaluronic Acid, Miconazole, Mice, Nanoparticles

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