Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections

Amaral, Andre Correa; Saavedra, Pedro H.V.; Oliveira Souza, Ana Camila; de Melo, Maryanne Trafani; Tedesco, Antonio Claudio; Morais, Paulo Cesar; Soares Felipe, Maria Sueli; Bocca, Anamelia Lorenzetti

doi:10.1016/j.colsurfb.2018.11.048

Cited by 59Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryReproductive tract infections research

Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections

Amaral, Andre Correa, Saavedra, Pedro H.V., Oliveira Souza, Ana Camila, de Melo, Maryanne Trafani, Tedesco, Antonio Claudio, Morais, Paulo Cesar, Soares Felipe, Maria Sueli, Bocca, Anamelia Lorenzetti·2019·Colloids and Surfaces B: Biointerfaces

DOI 10.1016/j.colsurfb.2018.11.048

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Abstract

OBJECTIVES: In this study, polymeric nanoparticles based on chitosan incorporating the antifungal miconazole nitrate were fabricated and testedin vivo using murine vulvovaginal candidiasis. METHODS: Nanoparticles prepared by the ionotropic gelation method presented 200 to 300 nm diameter and polydispersity indexes ranging from 0.2 to 0.4. The nanoparticles were prepared to incorporate 63.9 mg/mL of miconazole nitrate to be testedin vivo. Murine vulvovaginal candidiasis was standardized using estradiol valerate before the animals were challenged by Candida albicans. RESULTS: The treatment using chitosan nanoparticles within miconazole nitrate presented the same therapeutic efficacy as miconazole nitrate in a commercial cream formulation, however using the antifungal content about seven-fold lower. This increase in the miconazole nitrate's therapeutic efficacy is may be due to the down-regulation of interleukin 10 (IL-10) expression. CONCLUSIONS: Our data represent a proof of concept that can be exploited to achieve an alternative and promising therapy for the treatment of vulvovaginal candidiasis.

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Authors: Amaral, A. C., Saavedra, P. H. V., Oliveira Souza, A. C., de Melo, M. T., Tedesco, A. C., Morais, P. C., Soares Felipe, M. S., & Bocca, A. L.
Affiliations: VIB-UGent Center for Inflammation Research (BE)
Universidade de Brasília (BR)
ORCID: Amaral, Andre Correa
Saavedra, Pedro H.V.
Tedesco, Antonio Claudio
Morais, Paulo Cesar
Venue: Colloids and Surfaces B: Biointerfaces
Publisher: Elsevier BV
Published: 2019-02
Volume: 174
Pages: 409-415
ISSN: 0927-7765 (ISSN-L)
DOI: 10.1016/j.colsurfb.2018.11.048
OpenAlex: W2900838377
Cited by: 59
References: 27
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 12
FWCI: 2.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Colloids and Surfaces B Biointerfaces (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (559157/2008-8)
Fundação de Apoio à Pesquisa do Distrito Federal (193.000328/2007)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: miconazole nitrate, chitosan nanoparticles, vaginal candidiasis, Candida albicans, ionic gelation, antifungal drug delivery, local therapy, IL-10, mouse model, estradiol valerate
MeSH terms: Administration, Intravaginal, Animals, Antifungal Agents, Candida albicans, Candidiasis, Vulvovaginal, Female, Humans, Mice, Inbred BALB C, Miconazole, Chitosan, Mice, Nanoparticles

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Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections

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