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Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota
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“Long-term rejuvenation strategies have been shown to enhance organismal function, emphasizing the critical role of gut health in cardiovascular protection and overall healthy aging110,111.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [110]
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
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“Conversely, dasatinib inhibits multiple tyrosine kinases that reduce expression of ephrin ligand B proteins, which triggers cell death via inactivation of Eph receptors (Zhu et al., 2015; Furne et al., 2009).”
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277
Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · cited 1×
“Due to their activities on different SCAPs, dasatinib and quercetin ( D + Q ) are commonly co-administered for their synergistic effects as documented in preclinical and clinical studies (Novais et al., 2021; Saccon et al., 2021; Justice et al., 2019; Hickson et al., 2019).”
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · cited 1×
“Due to their activities on different SCAPs, dasatinib and quercetin ( D + Q ) are commonly co-administered for their synergistic effects as documented in preclinical and clinical studies (Novais et al., 2021; Saccon et al., 2021; Justice et al., 2019; Hickson et al., 2019).”
Mechanisms and functions of cellular senescence
Herranz, N., & Gil, J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95148 · Cited by 1,232
The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817
Cellular senescence: a key therapeutic target in aging and diseases
Zhang, L., Pitcher, L. E., Yousefzadeh, M. J., Niedernhofer, L. J., Robbins, P. D., & Zhu, Y. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158450 · Cited by 631
Cellular senescence: at the nexus between ageing and diabetes
Palmer, A. K., Gustafson, B., Kirkland, J. L., & Smith, U. (2019) · Diabetologia · doi:10.1007/s00125-019-4934-x · Cited by 337
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., et al. (2022) · Aging · doi:10.18632/aging.204248 · Cited by 319
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Cited by
Sorted by citations
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
Zhang, W., Song, S., Zhang, Y., Pan, Y., Hu, D., & Wang, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00355-z · Cited by 6
Metadata
- Authors
- Sangfuang, N., Xie, Y., McCoubrey, L. E., Taub, M., Favaron, A., Mai, Y., Gaisford, S., & Basit, A. W.
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2025-06
- Volume
- 209
- Pages
- 107098
- ISSN
- 0928-0987
- Cited by
- 5
- References
- 11
- Language
- en
- Licence
- Funders
- Engineering and Physical Sciences Research Council (EP/S023054/1)
- National Natural Science Foundation of China (82003672)
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