The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

Human gut microbiome viewed across age and geography

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

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The gut microbiota--masters of host development and physiology

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Gut microbiota composition correlates with diet and health in the elderly

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Accumulation of Deficits as a Proxy Measure of Aging

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The impact of dietary fiber on gut microbiota in host health and disease

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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works

Human gut microbes impact host serum metabolome and insulin sensitivity

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The Frailty Syndrome: Definition and Natural History

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Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

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High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

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Microbiota-mediated colonization resistance against intestinal pathogens

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Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

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Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

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The pros, cons, and many unknowns of probiotics

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Symptomatic atherosclerosis is associated with an altered gut metagenome

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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Gut microbiota and aging

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Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

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Akkermansia muciniphila and its role in regulating host functions

Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works

Gut Microbiota and Extreme Longevity

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Mediterranean Diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

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Regional variation limits applications of healthy gut microbiome reference ranges and disease models

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Neutrophil ageing is regulated by the microbiome

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Gluteofemoral body fat as a determinant of metabolic health

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Sex differences in frailty: A systematic review and meta-analysis

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Gut microbiota‐derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages

Krishnan, S., Ding, Y., Saedi, N., Choi, M., Sridharan, G. V., Sherr, D. H., Yarmush, M. L., Alaniz, R. C., Jayaraman, A., & Lee, K. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.109 · Cited by 679 · see citing works

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661 · see citing works

Butyrate-producingClostridiumcluster XIVa species specifically colonize mucins in anin vitrogut model

den Abbeele, P. V., Belzer, C., Goossens, M., Kleerebezem, M., de Vos, W. M., Thas, O., Weirdt, R. D., Kerckhof, F., & de Wiele, T. V. (2012) · The ISME Journal · doi:10.1038/ismej.2012.158 · Cited by 639 · see citing works

<i>Bacteroides vulgatus</i> and <i>Bacteroides dorei</i> Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis

Yoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.033714 · Cited by 619 · see citing works

Sexual-dimorphism in human immune system aging

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Mucin-bacterial interactions in the human oral cavity and digestive tract

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Precision editing of the gut microbiota ameliorates colitis

Zhu, W., Winter, M. G., Byndloss, M. X., Spiga, L., Duerkop, B. A., Hughes, E. R., Büttner, L., Romão, E. D. L., Behrendt, C. L., Lopez, C. A., et al. (2018) · Nature · doi:10.1038/nature25172 · Cited by 544 · see citing works

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

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Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018) · Microorganisms · doi:10.3390/microorganisms6030075 · Cited by 452 · see citing works

Signatures of early frailty in the gut microbiota

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Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

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Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

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Composition and temporal stability of the gut microbiota in older persons

Jeffery, I. B., Lynch, D. B., & O’Toole, P. W. (2016) · The ISME Journal · doi:10.1038/ismej.2015.88 · Cited by 421 · see citing works

Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis

Pianta, A., Arvikar, S. L., Strle, K., Drouin, E. E., Wang, Q., Costello, C. E., & Steere, A. C. (2016) · Arthritis & Rheumatology · doi:10.1002/art.40003 · Cited by 405 · see citing works

Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults

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Gut microbiota signatures of longevity

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Evolutionary trends in host physiology outweigh dietary niche in structuring primate gut microbiomes

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Functional metagenomic profiling of intestinal microbiome in extreme ageing

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Fecal Microbiota Composition and Frailty

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The dynamics of gut‐associated microbial communities during inflammation

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Gastrointestinal Tract Disorders in Older Age

Dumic, I., Nordin, T., Jecmenica, M., Lalošević, M. S., Milosavljević, T., & Milovanovic, T. (2019) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2019/6757524 · Cited by 315 · see citing works

NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

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Sex differences in the gut microbiome–brain axis across the lifespan

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Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

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Microbiota in the Gastrointestinal Tract

Dieterich, W., Schink, M., & Zopf, Y. (2018) · Medical Sciences · doi:10.3390/medsci6040116 · Cited by 269 · see citing works

The impact of gut microbiota on gender-specific differences in immunity

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A next-generation beneficial microbe: Akkermansia muciniphila

Naito, Y., Uchiyama, K., & Takagi, T. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-57 · Cited by 262 · see citing works

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

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Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan

Li, H., Qi, Y., & Jasper, H. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.008 · Cited by 241 · see citing works

Effects of ageing on gastrointestinal motor function.

Madsen, J., & Graff, J. (2004) · Age and Ageing · doi:10.1093/ageing/afh040 · Cited by 234 · see citing works

Adjusting for age improves identification of gut microbiome alterations in multiple diseases

Ghosh, T. S., Das, M., Jeffery, I. B., & O'Toole, P. W. (2020) · eLife · doi:10.7554/elife.50240 · Cited by 233 · see citing works

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

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The frailty index in Europeans: association with age and mortality

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Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

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A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians

Wu, L. H., Zeng, T., Zinellu, A., Rubino, S., Kelvin, D. J., & Carru, C. (2019) · mSystems · doi:10.1128/msystems.00325-19 · Cited by 198 · see citing works

Indoles from commensal bacteria extend healthspan

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Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans

Cabreiro, F., & Gems, D. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201100972 · Cited by 193 · see citing works

Gut Microbiota Community and Its Assembly Associated with Age and Diet in Chinese Centenarians

Fang, W., Yu, T., Huang, G., Cai, D., Liang, X., Su, H., Zhu, Z., Li, D., Yang, Y., Shen, P., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1410.10014 · Cited by 184 · see citing works

Determinants of healthy eating in community-dwelling elderly people.

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TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

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Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation

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Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

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Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups

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Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

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Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women: The HALE Project

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The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

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Changes in the Abundance of Faecalibacterium prausnitzii Phylogroups I and II in the Intestinal Mucosa of Inflammatory Bowel Disease and Patients with Colorectal Cancer

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Promoting healthy aging by confronting ageism.

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Evolution of the gut microbiome following acute HIV-1 infection

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Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Effectiveness of the Mediterranean diet in the elderly

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Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

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