Bovine Mesenteric Vein Graft (ProCol) in Critical Limb Ischaemia with Tissue Loss and Infection
Open accessAbstract
Objectives Poor results have been reported following infrainguinal reconstructions using heterogenous grafts. The objective of this study was to assess the use of bovine mesenteric vein (ProCol) graft in patients with critical limb ischaemia (CLI), tissue loss/infection and no autologous vein available for reconstruction. Methods Prospective analysis of 32 patients with CLI and tissue loss/infection, in whom reconstruction with ProCol was undertaken between October 1999 and May 2002. Results The primary patency rate was 16% at 1 month. After thrombectomy, the secondary patency rate was 50% at 1 month and 26% at 14 months. No graft infections were seen. Aneurysmal dilatation of the graft occurred in 2 (6%). Limb salvage at 14 months was 47%. Conclusion In patients with critical limb ischaemia, tissue loss/infection and no available vein, the ProCol graft may be an alternative. However, primary patency is a problem. In situations without tissue loss/infection, where the risk of graft infection is less, prosthetic material may be a better alternative.
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The use of ECM scaffolds in risk of infection scenarios is still an unclear option.
“On the other hand, the use of ECM scaffolds in risk of infection scenarios is still an unclear option [62,96,185,199]”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [199]
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- Authors
- Schmidli, J., Savolainen, H., Heller, G., Widmer, M. K., Then-Schlagau, U., Baumgartner, I., & Carrel, T. P.
- Affiliations
- University Hospital of Bern (CH)
- Corresponding author
- Schmidli, J
- Venue
- European Journal of Vascular and Endovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 27
- Issue
- 3
- Pages
- 251-253
- ISSN
- 1078-5884 (ISSN-L)
- OpenAlex
- W2139320919
- Cited by
- 33
- References
- 17
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Vascular and Endovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Surgery › Reconstructive Surgery and Microvascular Techniques
- Health Sciences › Medicine › Surgery › Infectious Aortic and Vascular Conditions
- Keywords
- critical limb ischemia, tissue loss, limb infection, infrainguinal reconstruction, graft patency, graft infection, limb salvage
- MeSH terms
- Adult, Aged, Aged, 80 and over, Animals, Cattle, Female, Humans, Ischemia, Leg, Male, Mesenteric Veins, Middle Aged, Transplantation, Heterologous, Vascular Surgical Procedures
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