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Cited by 81Air Quality and Health ImpactsHealth, Environment, Cognitive AgingEnvironmental Justice and Health Disparities

Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex

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Brunst, Kelly J., Sanchez-Guerra, Marco, Chiu, Yueh-Hsiu Mathilda, Wilson, Ander, Coull, Brent A., Kloog, Itai, Schwartz, Joel, Brennan, Kasey J. +4 more·2018·Environment International
DOI 10.1016/j.envint.2017.12.020PMC PMC6094933
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Abstract

Background Prenatal ambient fine particulate matter (PM 2.5) and maternal chronic psychosocial stress have independently been linked to changes in mithochondrial DNA copy number (mtDNAcn), a marker of mitochondrial response and dysfunction. Further, overlapping research shows sex-specific effects of PM 2.5 and stress on developmental outcomes. Interactions among PM 2.5, maternal stress, and child sex have not been examined in this context. Methods We examined associations among exposure to prenatal PM 2.5, maternal lifetime traumatic stressors, and mtDNAcn at birth in a sociodemographically diverse pregnancy cohort (N=167). Mothers' daily exposure to PM 2.5 over gestation was estimated using a satellite-based spatio-temporally resolved prediction model. Lifetime exposure to traumatic stressors was ascertained using the Life Stressor Checklist-Revised; exposure was categorized as high vs. low based on a median split. Quantitative real-time polymerase chain reaction (qPCR) was used to determine mtDNAcn in placenta and cord blood leukocytes. Bayesian Distributed Lag Interaction regression models (BDLIMs) were used to statistically model and visualize the PM 2.5 timing-dependent pattern of associations with mtDNAcn and explore effect modification by maternal lifetime trauma and child sex. Results Increased PM 2.5 exposure across pregnancy was associated with decreased mtDNAcn in cord blood (cumulative effect estimate=-0.78; 95%CI -1.41, -0.16). Higher maternal lifetime trauma was associated with reduced mtDNAcn in placenta (β=-0.33; 95%CI -0.63, -0.02). Among women reporting low trauma, increased PM 2.5 exposure late in pregnancy (30-38weeks gestation) was significantly associated with decreased mtDNAcn in placenta; no significant association was found in the high trauma group. BDLIMs identified a significant 3-way interaction between PM 2.5, maternal trauma, and child sex. Specifically, PM 2.5 exposure between 25 and 40weeks gestation was significantly associated with increased placental mtDNAcn among boys of mothers reporting high trauma. In contrast, PM 2.5 exposure in this same window was significantly associated with decreased placental mtDNAcn among girls of mothers reporting low trauma. Similar 3-way interactive effects were observed in cord blood. Conclusions These results indicate that joint exposure to PM 2.5 in late pregnancy and maternal lifetime trauma influence mtDNAcn at the maternal-fetal interface in a sex-specific manner. Additional studies will assist in understanding if the sex-specific patterns reflect distinct pathophysiological processes in addition to mitochondrial dysfunction.

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Authors
Brunst, K. J., Sanchez-Guerra, M., Chiu, Y.-H. M., Wilson, A., Coull, B. A., Kloog, I., Schwartz, J., Brennan, K. J., Bosquet Enlow, M., Wright, R. O., Baccarelli, A. A., & Wright, R. J.
Affiliations
  • University of Cincinnati (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Colorado State University (US)
  • Harvard University (US)
  • Ben-Gurion University of the Negev (IL)
  • Columbia University Irving Medical Center (US)
Corresponding author
Brunst, Kelly J.
ORCID
Venue
Environment International
Publisher
Elsevier BV
Published
2018-03
Volume
112
Pages
49-58
ISSN
0160-4120 (ISSN-L)
DOI
10.1016/j.envint.2017.12.020
PMC
PMC6094933
OpenAlex
W2773991077
Cited by
81
References
8
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 19 · 2021: 11 · 2020: 10 · 2019: 11 · 2018: 5
FWCI
3.83
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environment International (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute of Environmental Health Sciences (P30ES006096, R00ES024116, K99ES024116, P30ES023515)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
Keywords
PM2.5, maternal psychosocial stress, mitochondrial DNA copy number, mitochondrial dysfunction, maternal-fetal interface, placenta, cord blood leukocytes, child sex differences, effect modification, air pollution exposure, pregnancy timing, pregnancy cohort study
MeSH terms
DNA, Mitochondrial, Female, Humans, Male, Pregnancy, Maternal Exposure, Particulate Matter, DNA Copy Number Variations

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