Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology
Open accessAbstract
Background Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation to stress exposure.Methods Two-hundred ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews. Participants were categorized into four groups based upon the presence or absence of childhood adversity and the presence or absence of lifetime psychopathology (depressive, anxiety, and substance use disorders). Telomere length and mitochondrial DNA (mtDNA) copy number were measured from leukocyte DNA by quantitative polymerase chain reaction.Results Childhood adversity and lifetime psychopathology were each associated with shorter telomeres (p < .01) and higher mtDNA copy numbers (p < .001). Significantly higher mtDNA copy numbers and shorter telomeres were seen in individuals with major depression, depressive disorders, and anxiety disorders, as well as those with parental loss and childhood maltreatment. A history of substance disorders was also associated with significantly higher mtDNA copy numbers.Conclusions This study provides the first evidence of an alteration of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders. We replicate prior work on telomere length and psychopathology and show that this effect is not secondary to medication use or comorbid medical illness. Finally, we show that early life stress and psychopathology are each associated with these markers of cellular aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Different types of childhood adversity are associated with shorter telomere length in both children and adults.
“In both children and adults, different types of childhood adversity are associated with shorter telomere length.6–8”
From Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project (2020) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC)
Connor, K. M., & Davidson, J. R. T. (2003) · Depression and Anxiety · doi:10.1002/da.10113 · Cited by 11,793 · see citing works
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577 · see citing works
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168 · see citing works
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101 · see citing works
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works
Stress and Health: Psychological, Behavioral, and Biological Determinants
Schneiderman, N., Ironson, G., & Siegel, S. D. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144141 · Cited by 2,252 · see citing works
The Inventory of Depressive Symptomatology (IDS): Psychometric properties
Rush, A. J., Gullion, C. M., Basco, M. R., Jarrett, R. B., & Trivedi, M. H. (1996) · Psychological Medicine · doi:10.1017/s0033291700035558 · Cited by 2,177 · see citing works
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188 · see citing works
The role of mitochondria in aging
Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709 · see citing works
Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.014 · Cited by 682 · see citing works
Liu, R. T., & Alloy, L. B. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.010 · Cited by 676 · see citing works
Clarke, D. M., & Currie, K. C. (2009) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2009.tb02471.x · Cited by 661 · see citing works
Number matters: control of mammalian mitochondrial DNA copy number
Montier, L., Deng, J., & Bai, Y. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60099-5 · Cited by 513 · see citing works
A quantitative PCR method for measuring absolute telomere length
O’Callaghan, N. J., & Fenech, M. F. (2011) · Biological Procedures Online · doi:10.1186/1480-9222-13-3 · Cited by 490 · see citing works
Shalev, I., Moffitt, T. E., Sugden, K., Williams, B., Houts, R. M., Danese, A., Mill, J., Arseneault, L., & Caspi, A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.32 · Cited by 489 · see citing works
Mitochondrial dysfunction in autism
Giulivi, C., Zhang, Y.-F., Omanska-Klusek, A., Ross-Inta, C., Wong, S., Hertz-Picciotto, I., Tassone, F., & Pessah, I. N. (2010) · JAMA · doi:10.1001/jama.2010.1706 · Cited by 466 · see citing works
Grippo, A. J., & Johnson, A. K. (2009) · Stress · doi:10.1080/10253890802046281 · Cited by 451 · see citing works
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids
Picard, M., Juster, R.-P., & McEwen, B. S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.22 · Cited by 405 · see citing works
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400 · see citing works
Axis of ageing: telomeres, p53 and mitochondria
Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works
Glutamate neurotoxicity, oxidative stress and mitochondria
Atlante, A., Calissano, P., Bobba, A., Giannattasio, S., Marra, E., & Passarella, S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02437-1 · Cited by 360 · see citing works
Tyrka, A. R., Price, L. H., Kao, H.-T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.014 · Cited by 342 · see citing works
Self-citationTelomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works
Self-citationDepression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298 · see citing works
Verhoeven, J. E., Révész, D., Epel, E. S., Lin, J., Wolkowitz, O. M., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.151 · Cited by 270 · see citing works
The role of mitochondrial DNA mutations and free radicals in disease and ageing
Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works
Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
O'Donovan, A., Epel, E., Lin, J., Wolkowitz, O., Cohen, B., Maguen, S., Metzler, T., Lenoci, M., Blackburn, E., & Neylan, T. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.035 · Cited by 262 · see citing works
Telomeres and lifestyle factors: Roles in cellular aging.
Lin, J., Epel, E., & Blackburn, E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.08.003 · Cited by 251 · see citing works
Karabatsiakis, A., Böck, C., Salinas-Manrique, J., Kolassa, S., Calzia, E., Dietrich, D. E., & Kolassa, I. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.44 · Cited by 237 · see citing works
Oncogenes in Cell Survival and Cell DeathPreprint
Shortt, J., & Johnstone, R. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009829 · Cited by 195 · see citing works
Vawter, M. P., Tomita, H., Meng, F., Bolstad, B. M., Li, J., Evans, S. J., Choudary, P. V., Atz, M. E., Shao, L., Neal, C. R., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001830 · Cited by 181 · see citing works
Glucocorticoids induce mitochondrial gene transcription in HepG2 cells
Psarra, A. G., & Sekeris, C. E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.05.014 · Cited by 175 · see citing works
Theall, K. P., Brett, Z. H., Shirtcliff, E. A., Dunn, E. C., & Drury, S. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.030 · Cited by 175 · see citing works
Wikgren, M., Maripuu, M., Karlsson, T., Nordfjäll, K., Bergdahl, J., Hultdin, J., Del‐Favero, J., Roos, G., Nilsson, L., Adolfsson, R., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.015 · Cited by 173 · see citing works
Shortened telomeres in individuals with abuse in alcohol consumption
Pavanello, S., Hoxha, M., Dioni, L., Bertazzi, P. A., Snenghi, R., Nalesso, A., Ferrara, S. D., Montisci, M., & Baccarelli, A. (2011) · International Journal of Cancer · doi:10.1002/ijc.25999 · Cited by 167 · see citing works
The Role of Stress Factors during Aging of the Immune System
Bauer, M. E., Jeckel, C. M. M., & Luz, C. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03966.x · Cited by 167 · see citing works
Medication‐induced mitochondrial damage and disease
Neustadt, J. O., & Pieczenik, S. R. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700075 · Cited by 158 · see citing works
Hartmann, N., Boehner, M., Groenen, F., & Kalb, R. (2010) · Depression and Anxiety · doi:10.1002/da.20749 · Cited by 156 · see citing works
Shalev, I., Moffitt, T. E., Braithwaite, A. W., Danese, A., Fleming, N. I., Goldman-Mellor, S., Harrington, H. L., Houts, R. M., Israel, S., Poulton, R., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.183 · Cited by 155 · see citing works
Human Mitochondrial DNA ReplicationPreprint
Holt, I. J., & Reyes, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012971 · Cited by 155 · see citing works
Bai, R., & Wong, L. C. (2005) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60595-8 · Cited by 152 · see citing works
Bojesen, S. E. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12083 · Cited by 141 · see citing works
Elvsåshagen, T., Vera, E., Bøen, E., Bratlie, J., Andreassen, O. A., Josefsen, D., Malt, U. F., Blasco, M. A., & Boye, B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.006 · Cited by 133 · see citing works
Marques‐Aleixo, I., Oliveira, P. J., Moreira, P. I., Magalhães, J., & Ascensão, A. A. M. R. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.002 · Cited by 132 · see citing works
Rapid telomere erosion in schizophrenia
Kao, H.-T., Cawthon, R. M., DeLisi, L. E., Bertisch, H. C., Ji, F., Gordon, D., Li, P., Benedict, M. M., Greenberg, W. M., & Porton, B. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002105 · Cited by 128 · see citing works
Self-citationAsok, A., Bernard, K., Roth, T. L., Rosen, J. B., & Dozier, M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000011 · Cited by 128 · see citing works
Kim, J., Kim, H. K., Ko, J., Bang, H., & Lee, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067227 · Cited by 109 · see citing works
Mitochondrial respiration in blood platelets of depressive patients
Hroudová, J., Fišar, Z., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.05.005 · Cited by 108 · see citing works
Hoen, P. W., de Jonge, P., Na, B. Y., Farzaneh-Far, R., Epel, E., Lin, J., Blackburn, E., & Whooley, M. A. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821b1f6e · Cited by 106 · see citing works
Number matters： control of mammalian mitochondrial DNA copy number
Laura, L., Clay, Montier, Janice, Deng, Yidong, & Bai (2009) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 103 · see citing works
Short telomeres in patients with chronic schizophrenia who show a poor response to treatment
Yu, W., Chang, H., Lin, C., & Cho, C.-L. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0825 · Cited by 96 · see citing works
Mitochondrial Mutations and Polymorphisms in Psychiatric Disorders
Sequeira, A., Martin, M. V., Rollins, B. L., Moon, E. A., Bunney, W. E., Macciardi, F. M., Lupoli, S., Smith, E. N., Kelsoe, J. R., Magnan, C. N., et al. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00103 · Cited by 93 · see citing works
Hoen, P. W., Rosmalen, J. G. M., Schoevers, R. A., Huzen, J., van der Harst, P., & de Jonge, P. (2013) · Psychological Medicine · doi:10.1017/s0033291712001766 · Cited by 88 · see citing works
Psarra, A. G., & Sekeris, C. E. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.11.011 · Cited by 87 · see citing works
Zhang, L., Zhou, R., Li, X., Ursano, R. J., & Li, H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.041 · Cited by 87 · see citing works
Garcia-Rizo, C., Fernandez-Egea, E., Miller, B. J., Oliveira, C., Justicia, A., Griffith, J. K., Heaphy, C. M., Bernardo, M., & Kirkpatrick, B. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.11.009 · Cited by 84 · see citing works
Telomeres and cardiovascular disease risk: an update 2013
Nilsson, P. M., Tufvesson, H., Leósdóttir, M., & Melander, O. (2013) · Translational research · doi:10.1016/j.trsl.2013.05.004 · Cited by 83 · see citing works
Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women
Kim, M.-Y., Lee, J., Kang, H., Kim, E., & Lee, D. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.11.019 · Cited by 82 · see citing works
STRECK, E. L., Gonçalves, C. L., Furlanetto, C. B., Scaini, G., Dal‐Pizzol, F., & Quevedo, J. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1224 · Cited by 82 · see citing works
No Correlation Between Childhood Maltreatment and Telomere Length
Glass, D., Parts, L., Knowles, D. A., Aviv, A., & Spector, T. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.026 · Cited by 76 · see citing works
Chang, C., Jou, S., Lin, T., & Liu, C. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12163 · Cited by 72 · see citing works
Kakiuchi, C., Ishiwata, M., Kametani, M., Nelson, C., Iwamoto, K., & Kato, T. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005213 · Cited by 72 · see citing works
Savolainen, K., Eriksson, J. G., Kananen, L., Kajantie, E., Pesonen, A., Heinonen, K., & Räikkönen, K. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.02.002 · Cited by 70 · see citing works
The mitochondrial genome and psychiatric illness
Anglin, R., Mazurek, M. F., Tarnopolsky, M. A., & Rosebush, P. I. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32086 · Cited by 69 · see citing works
The interaction between stressful life events and leukocyte telomere length is associated with PTSD
Zhang, L., Hu, X.-Z., Benedek, D. M., Fullerton, C. S., Forsten, R. D., Naifeh, J. A., Li, X., Li, H., Benevides, K. N., Smerin, S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.141 · Cited by 69 · see citing works
Telomere shortening in leukocyte subpopulations in depression
Karabatsiakis, A., Kolassa, I., Kolassa, S., Rudolph, K. L., & Dietrich, D. E. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-192 · Cited by 67 · see citing works
Mitochondrial DNA Damage Patterns and Aging: Revising the Evidences for Humans and Mice
Kazachkova, N. (2013) · Aging and Disease · doi:10.14336/ad.2013.0400337 · Cited by 63 · see citing works
Ladwig, K., Brockhaus, A. C., Baumert, J., Lukaschek, K., Emeny, R. T., Kruse, J., Codd, V., Häfner, S., Albrecht, E., Illig, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064762 · Cited by 63 · see citing works
No association between mean telomere length and life stress observed in a 30 year birth cohort
Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097102 · Cited by 62 · see citing works
Investigation of telomere length and psychological stress in rape victims
Malan‐Müller, S., Hemmings, S. M. J., Kidd, M., Martin, L. I., & Seedat, S. (2011) · Depression and Anxiety · doi:10.1002/da.20903 · Cited by 60 · see citing works
Leukocyte mitochondrial DNA copy number in bipolar disorder
SOUSA, R. T. D., Uno, M., Zanetti, M. V., Oba‐Shinjo, S. M., Busatto, G. F., Gattaz, W. F., Marie, S. K. N., & Machado‐Vieira, R. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.002 · Cited by 57 · see citing works
Hé, Y., Tang, J., Li, Z., Li, H., Liao, Y., Tang, Y., Tan, L., Chen, J., Xia, K., & Chen, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096869 · Cited by 56 · see citing works
Shaffer, J. A., Epel, E. S., Kang, M. S., Ye, S., Schwartz, J. E., Davidson, K. W., Kirkland, S., Honig, L. S., & Shimbo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048318 · Cited by 56 · see citing works
Drug addiction is associated with leukocyte telomere length
Yang, Z., Ye, J., Li, C., Zhou, D., Shen, Q., Wu, J., Cao, L., Wang, T., Cui, D., He, S., et al. (2013) · Scientific Reports · doi:10.1038/srep01542 · Cited by 55 · see citing works
Torrell-Galceran, H., Montaña, E., Abasolo-Zabalo, N., Roig, B., Gaviria, A. M., Vilella, E., & Martorell, L. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32134 · Cited by 52 · see citing works
Sabunciyan, S., Kirches, E., Krause, G., Bogerts, B., Mawrin, C., Llenos, I. C., & Weis, S. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0581-8 · Cited by 50 · see citing works
Ale‐Agha, N., Dyballa‐Rukes, N., Jakob, S., Altschmied, J., & Haendeler, J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.011 · Cited by 49 · see citing works
Cellular aging in depression: Permanent imprint or reversible process?
Verhoeven, J. E., Révész, D., Wolkowitz, O. M., & Penninx, B. W. J. H. (2014) · BioEssays · doi:10.1002/bies.201400068 · Cited by 44 · see citing works
Telomere biology and translational research
Mason, P. J., & Perdigones, N. (2013) · Translational research · doi:10.1016/j.trsl.2013.08.009 · Cited by 42 · see citing works
Savolainen, K., Räikkönen, K., Kananen, L., Kajantie, E., Hovatta, I., Lahti, M., Lahti, J., Pesonen, A.-K., Heinonen, K., & Eriksson, J. G. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.07.005 · Cited by 40 · see citing works
Telomerase and its extracurricular activities
Jaiswal, R. K., Kumar, P., & Yadava, P. K. (2013) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-013-0105-0 · Cited by 36 · see citing works
Early‐life‐stress affects the homeostasis of glutamatergic synapses
Toya, S., Takatsuru, Y., Kokubo, M., Amano, I., Shimokawa, N., & Koibuchi, N. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12728 · Cited by 30 · see citing works
Chan, S. W., Chevalier, S., Aprikian, A. G., & Chen, J. Z. (2012) · BioMed Research International · doi:10.1155/2013/157547 · Cited by 28 · see citing works
Lin, P., Mobasher, M. E., & Alawi, F. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.114 · Cited by 18 · see citing works
Silvestre, D. C., & Londoño‐Vallejo, A. (2012) · Genome dynamics · doi:10.1159/000337128 · Cited by 10 · see citing works
eNOS se correlaciona com a biogênese mitocondrial em corações com cardiopatia congênita e cianose
Xiao, J., Chen, L., Wang, X., Liu, M., & Xiao, Y. (2012) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2012005000072 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [73]Spielberger CD 1989 State-Trait Anxiety Inventory: A Comprehensive Bibliography Palo Alto, CA Consulting Psychologists Press
Cited by
Sorted by citations
Colich, N. L., Rosen, M. L., Williams, E. S., & McLaughlin, K. A. (2020) · Psychological Bulletin · doi:10.1037/bul0000270 · Cited by 433 · see citing works
Life Course Approaches to the Causes of Health Disparities
Jones, N. L., Gilman, S. E., Cheng, T. L., Drury, S. S., Hill, C. V., & Geronimus, A. T. (2019) · American Journal of Public Health · doi:10.2105/ajph.2018.304738 · Cited by 414 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Psychological Stress and Mitochondria: A Systematic Review
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000545 · Cited by 339 · see citing works
Picard, M., McManus, M. J., Gray, J. D., Nasca, C., Moffat, C., Kopinski, P. K., Seifert, E. L., McEwen, B. S., & Wallace, D. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515733112 · Cited by 293 · see citing works
Mitochondrial function in the brain links anxiety with social subordination
Hollis, F., van der Kooij, M. A., Zanoletti, O., Lozano, L., Cantó, C., & Sandi, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512653112 · Cited by 288 · see citing works
Early life adversity and telomere length: a meta-analysis
Ridout, K. K., Levandowski, M., Ridout, S. J., Gantz, L., Goonan, K., Palermo, D., Price, L. H., & Tyrka, A. R. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.26 · Cited by 273 · see citing works
Self-citationHigh anxiety trait: A vulnerable phenotype for stress‐induced depression
Weger, M., & Sandi, C. (2018) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.012 · Cited by 234 · see citing works
Mathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., & Khazeni, N. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.002 · Cited by 252 · see citing works
Depression and telomere length: a meta-analysis
Ridout, K. K., Ridout, S. J., Price, L. H., Sen, S., & Tyrka, A. R. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.052 · Cited by 258 · see citing works
Self-citationLindqvist, D., Wolkowitz, O. M., Picard, M., Ohlsson, L., Bersani, F. S., Fernström, J., Westrin, Å., Hough, C. M., Lin, J., Reus, V. I., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-017-0001-9 · Cited by 188 · see citing works
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders
Kim, Y., Vadodaria, K. C., Lenkei, Z., Kato, T., Gage, F. H., Marchetto, M. C., & Santos, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7606 · Cited by 189 · see citing works
Blood mitochondrial DNA copy number: What are we counting?
Picard, M. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.010 · Cited by 183 · see citing works
The effects of early life adversity on the immune system
Elwenspoek, M. M. C., Kuehn, A., Muller, C. P., & Turner, J. D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.012 · Cited by 180 · see citing works
Stress-induced biological aging: A review and guide for research priorities
Polsky, L. R., Rentscher, K. E., & Carroll, J. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.016 · Cited by 181 · see citing works
Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder
Fries, G. R., Bauer, I. E., Scaini, G., Wu, M., Kazimi, I. F., Valvassori, S. S., Zunta‐Soares, G. B., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0048-8 · Cited by 162 · see citing works
Anxiety and Brain Mitochondria: A Bidirectional Crosstalk
Filiou, M. D., & Sandi, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.002 · Cited by 164 · see citing works
Stress and Psychiatric Disorders: The Role of Mitochondria
Daniels, T. E., Olsen, E. M., & Tyrka, A. R. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-082719-104030 · Cited by 157 · see citing works
Self-citationThe energetic cost of allostasis and allostatic load
Bobba‐Alves, N., Juster, R., & Picard, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105951 · Cited by 155 · see citing works
Childhood adversities and depression in adulthood: Current findings and future directions.
Liu, R. T. (2017) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12190 · Cited by 147 · see citing works
Accelerated DNA methylation age: Associations with PTSD and neural integrity
Wolf, E. J., Logue, M. W., Hayes, J. P., Sadeh, N., Schichman, S. A., Stone, A., Salat, D. H., Milberg, W., McGlinchey, R. E., & Miller, M. W. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.020 · Cited by 146 · see citing works
Chronic stress and body composition disorders: implications for health and disease
Stefanaki, C., Pervanidou, P., Boschiero, D., & Chrousos, G. P. (2018) · HORMONES · doi:10.1007/s42000-018-0023-7 · Cited by 135 · see citing works
Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment
Jaworska-Andryszewska, P., & RYBAKOWSKI, J. K. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.10.004 · Cited by 128 · see citing works
Tyrka, A. R., Carpenter, L. L., Kao, H.-T., Porton, B., Philip, N. S., Ridout, S. J., Ridout, K. K., & Price, L. H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.04.002 · Cited by 125 · see citing works
Self-citationBoeck, C., Koenig, A. M., Schury, K., Geiger, M. L., Karabatsiakis, A., Wilker, S., Waller, C., Gündel, H., Fegert, J. M., Calzia, E., et al. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.006 · Cited by 120 · see citing works
Childhood maltreatment and methylation of FK506 binding protein 5 gene (<i>FKBP5</i>)
Tyrka, A. R., Ridout, K. K., Parade, S. H., Paquette, A., Marsit, C. J., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000991 · Cited by 118 · see citing works
Self-citationRidout, K. K., Khan, M. B., & Ridout, S. J. (2018) · BioEssays · doi:10.1002/bies.201800077 · Cited by 118 · see citing works
Correlates of Peripheral Blood Mitochondrial DNA Content in a General Population
Knez, J., Winckelmans, E., Plusquin, M., Thijs, L., Cauwenberghs, N., Gu, Y., Staessen, J. A., Nawrot, T. S., & Kuznetsova, T. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv175 · Cited by 116 · see citing works
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress
Picard, M. A., Prather, A. A., Puterman, E. M., Cuillerier, A., Coccia, M., Aschbacher, K., Burelle, Y., & Epel, E. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.012 · Cited by 113 · see citing works
Lindqvist, D., Fernström, J., Grudet, C., Ljunggren, L., Träskman-Bendz, L., Ohlsson, L., & Westrin, Å. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.236 · Cited by 111 · see citing works
Fries, G. R., Zamzow, M. J., Andrews, T., Pink, O., Scaini, G., & Quevedo, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.035 · Cited by 110 · see citing works
Deng, D., Cui, Y., Gan, S., Xie, Z., Cui, S., Cao, K., Wang, S., Shi, G., Yang, L., Bai, S., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154395 · Cited by 109 · see citing works
Anderson, G. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.022 · Cited by 108 · see citing works
Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.004 · Cited by 104 · see citing works
“adult psychopathology have been linked to higher mtDNAcn (Cai et al., 2015; Tyrka et al., 2016).”
Self-citationThe relationship between childhood psychosocial stressor level and telomere length: a meta-analysis
M. Hanssen, L., S. Schutte, N., M. Malouff, J., & S. Epel, E. (2017) · Health Psychology Research · doi:10.4081/hpr.2017.6378 · Cited by 93 · see citing works
“Other studies compared participants in categories of amount of childhood psychosocial stressors, such as high or low exposure to stressors (e.g., Tyrka et al., 2015) Many studies (e.g., Kananen et al., 2010) used measures relying on retrospective memory of participants or others, such as parents,…”
BackgroundMitochondrial DNA copy number is reduced in male combat veterans with PTSD
Bersani, F. S., Morley, C., Lindqvist, D., Epel, E. S., Picard, M. A., Yehuda, R., Flory, J. D., Bierer, L. M., Makotkine, I., Amara, D. A., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.012 · Cited by 93 · see citing works
Our (Mother’s) Mitochondria and Our Mind
Krämer, P., & Bressan, P. (2017) · Perspectives on Psychological Science · doi:10.1177/1745691617718356 · Cited by 94 · see citing works
Verhoeven, J. E., Révész, D., Picard, M. A., Epel, E. S., Wolkowitz, O. M., Matthews, K. A., Penninx, B. W. J. H., & Puterman, E. M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.48 · Cited by 87 · see citing works
Shortened telomere length in patients with depression: A meta-analytic study
Lin, P., Huang, Y., & Hung, C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.015 · Cited by 85 · see citing works
Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity
Wolf, E. J., Bovin, M. J., Green, J. D., Mitchell, K. S., Stoop, T. B., Barretto, K., Jackson, C. E., Lee, L. O., Fang, S. C., Trachtenberg, F. L., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716000817 · Cited by 85 · see citing works
Li, Z., He, Y., Wang, D., Tang, J., & Chen, X. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.06.002 · Cited by 84 · see citing works
Scaini, G., Fries, G. R., Valvassori, S. S., Zeni, C., Zunta‐Soares, G. B., Berk, M., Soares, J. C., & Quevedo, J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.83 · Cited by 84 · see citing works
Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
Chen, M. A., LeRoy, A. S., Majd, M., Chen, J. Y., Brown, R. L., Christian, L. M., & Fagundes, C. P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.788351 · Cited by 85 · see citing works
Brunst, K. J., Sanchez-Guerra, M., Chiu, Y.-H. M., Wilson, A., Coull, B. A., Kloog, I., Schwartz, J., Brennan, K. J., Bosquet Enlow, M., Wright, R. O., et al. (2018) · Environment International · doi:10.1016/j.envint.2017.12.020 · Cited by 81 · see citing works
Karanikas, E., Daskalakis, N. P., & Agorastos, A. (2021) · Brain Sciences · doi:10.3390/brainsci11060723 · Cited by 78 · see citing works
Stress and glucocorticoid receptor regulation of mitochondrial gene expression
Lapp, H. E., Bartlett, A. A., & Hunter, R. G. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0152 · Cited by 78 · see citing works
Psychological and biological mechanisms linking trauma with cardiovascular disease risk
Sumner, J. A., Cleveland, S., Chen, T., & Gradus, J. L. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02330-8 · Cited by 77 · see citing works
Osler, M., Bendix, L., Rask, L., & Rod, N. H. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.154 · Cited by 76 · see citing works
Tiwari, A., & Gonzalez, A. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.01.006 · Cited by 71 · see citing works
Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation
Huang, W., Hu, W., Cai, L., Zeng, G., Fang, W., Dai, X., Ye, Q., Chen, X., & Zhang, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.121 · Cited by 73 · see citing works
What Can Mitochondrial DNA Analysis Tell Us About Mood Disorders?
Kasahara, T., & Kato, T. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.010 · Cited by 69 · see citing works
Mitophagy in depression: Pathophysiology and treatment targets
Tripathi, A., Scaini, G., Barichello, T., Quevedo, J., & Pillai, A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.08.016 · Cited by 69 · see citing works
do Prado, C. H., Grassi‐Oliveira, R., Daruy-Filho, L., Wieck, A., & Bauer, M. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.137 · Cited by 69 · see citing works
The Stress Acceleration Hypothesis of Nightmares
Nielsen, T. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00201 · Cited by 63 · see citing works
“neural effects of early adversity The literature covering adversity-induced changes in neural development in humans (34, 181, 182), non-human primates (183), and rodents (184) is too extensive to review here.”
BackgroundHollis, F., Mitchell, E. S., Cantó, C., Wang, D., & Sandi, C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.017 · Cited by 68 · see citing works
Mitochondrial psychobiology: foundations and applications
Picard, M. A., Trumpff, C., & Burelle, Y. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.04.015 · Cited by 66 · see citing works
Telomere length is associated with childhood trauma in patients with severe mental disorders
Aas, M., Elvsåshagen, T., Westlye, L. T., Kaufmann, T., Athanasiu, L., Djurovic, S., Melle, I. S., van der Meer, D., Martin-Ruiz, C. M., Steen, N. E., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0432-7 · Cited by 65 · see citing works
Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?
Shalev, I., & Belsky, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.03.002 · Cited by 64 · see citing works
The Mitochondrion as Potential Interface in Early-Life Stress Brain Programming
Hoffmann, A., & Spengler, D. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00306 · Cited by 63 · see citing works
Baseline biopsychosocial determinants of telomere length and 6-year attrition rate
Révész, D., Milaneschi, Y., Terpstra, E. M., & Penninx, B. W. J. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.007 · Cited by 63 · see citing works
Telomere Shortening and Psychiatric Disorders: A Systematic Review
Pousa, P. A., de Souza, R. M., Melo, P. H. M., Correa, B. H. M., Mendonça, T. S. C., Silva, A. C. S. E., & de Miranda, D. M. (2021) · Cells · doi:10.3390/cells10061423 · Cited by 62 · see citing works
Allen, J., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.11.010 · Cited by 60 · see citing works
A meta-analysis of the relationship between anxiety and telomere length
Malouff, J. M., & Schutte, N. S. (2016) · Anxiety Stress & Coping · doi:10.1080/10615806.2016.1261286 · Cited by 56 · see citing works
Aberrant telomere length and mitochondrial DNA copy number in suicide completers
Otsuka, I., Izumi, T., Boku, S., Kimura, A., Zhang, Y., Mouri, K., Okazaki, S., Shiroiwa, K., Takahashi, M., Ueno, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03599-8 · Cited by 62 · see citing works
Wolf, E. J., Sadeh, N., Leritz, E. C., Logue, M. W., Stoop, T. B., McGlinchey, R. E., Milberg, W., & Miller, M. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.023 · Cited by 55 · see citing works
Belsky, J., & Shalev, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000900 · Cited by 56 · see citing works
Stressed mitochondria: A target to intrude alzheimer’s disease
Sharma, V., Singh, T. G., & Mehta, V. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.004 · Cited by 54 · see citing works
Seal, S. V., & Turner, J. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073344 · Cited by 54 · see citing works
Lilja, S., Stoll, C., Krammer, U. D. B., Hippe, B., Duszka, K., Debebe, T., Höfinger, I., König, J. S., Pointner, A., & Haslberger, A. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052331 · Cited by 53 · see citing works
Chen, X., Zeng, C., Gong, C., Zhang, L., Wan, Y., Tao, F., & Sun, Y. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.021 · Cited by 51 · see citing works
Ridout, K. K., Parade, S. H., Kao, H., Magnan, S., Seifer, R., Porton, B., Price, L. H., & Tyrka, A. R. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.015 · Cited by 51 · see citing works
Self-citationGumpp, A. M., Boeck, C., Behnke, A., Bach, A. M., Ramo‐Fernández, L., Welz, T., Gündel, H., Kolassa, I., & Karabatsiakis, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005885117 · Cited by 49 · see citing works
Mitochondria and early-life adversity
Zitkovsky, E. K., Daniels, T. E., & Tyrka, A. R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.005 · Cited by 51 · see citing works
Self-citationMitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment
Kumar, P., Efstathopoulos, P., Millischer, V., Olsson, E., Wei, Y. B., Brüstle, O., Schalling, M., Villaescusa, J. C., Ösby, U., & Lavebratt, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-31122-0 · Cited by 49 · see citing works
Thijssen, S., Collins, P. F., & Luciana, M. M. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000580 · Cited by 48 · see citing works
Li, L., Zhang, H., Chen, B., Xia, B., Zhu, R., Liu, Y., Dai, X., Ye, Z., Zhao, D., Mo, F., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114653 · Cited by 49 · see citing works
Roberts, A. L., Koenen, K. C., Chen, Q., Gilsanz, P., Mason, S. M., Prescott, J., Ratanatharathorn, A. D., Rimm, E. B., Sumner, J. A., Winning, A., et al. (2017) · Depression and Anxiety · doi:10.1002/da.22620 · Cited by 48 · see citing works
Bürgin, D., O’Donovan, A., d’Huart, D., Gallo, A. D., Eckert, A., Fegert, J. M., Schmeck, K., Schmid, M., & Boonmann, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00490 · Cited by 49 · see citing works
Investigation of mitochondrial DNA copy number in patients with major depressive disorder
Chung, J. K., Lee, S. Y., Park, M., Joo, E.-J., & Kim, S. A. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112616 · Cited by 48 · see citing works
Early life adversity predicts brain-gut alterations associated with increased stress and mood
Coley, E. J. L., Mayer, E. A., Osadchiy, V., Chen, Z., Subramanyam, V., Zhang, Y., Hsiao, E. Y., Gao, K., Bhatt, R. R., Dong, T. S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100348 · Cited by 48 · see citing works
Consequences of measurement error in qPCR telomere data: A simulation study
Nettle, D., Seeker, L. A., Nussey, D. H., Froy, H., & Melissa Bateson, B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216118 · Cited by 47 · see citing works
Zhao, H., Song, R., Ye, Y., Chow, W., & Shen, J. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06102-0 · Cited by 47 · see citing works
Rappeneau, V., Wilmes, L., & Touma, C. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103555 · Cited by 46 · see citing works
Tripathi, A., Bartosh, A., Whitehead, C., & Pillai, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02189-7 · Cited by 46 · see citing works
Psychosocial experiences are associated with human brain mitochondrial biology
Trumpff, C., Monzel, A. S., Sandi, C., Menon, V., Klein, H., Fujita, M., Lee, A., Petyuk, V., Hurst, C. D., Duong, D. M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317673121 · Cited by 45 · see citing works
Kupsco, A. J., Sánchez-Guerra, M., Amarasiriwardena, C. J., Brennan, K. J. M., Estrada‐Gutiérrez, G., Svensson, K., Schnaas, L., Pantic, I., Téllez‐Rojo, M. M., Baccarelli, A., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.02.029 · Cited by 45 · see citing works
Wang, B., Katsube, T., Begum, N., & Nenoi, M. (2016) · Journal of Radiation Research · doi:10.1093/jrr/rrw035 · Cited by 50 · see citing works
Kaufman, J., Gelernter, J. E., Hudziak, J. J., Tyrka, A. R., & Coplan, J. D. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.06.001 · Cited by 45 · see citing works
Self-citationWade, M., Fox, N. A., Zeanah, C. H., Nelson, C. A., & Drury, S. S. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.02.013 · Cited by 43 · see citing works
Dimensions of childhood adversity differentially affect biological aging in major depression
Rampersaud, R., Protsenko, E., Yang, R., Reus, V. I., Hammamieh, R., Wu, G. W. Y., Epel, E. S., Jett, M., Gautam, A., Mellon, S. H., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02198-0 · Cited by 41 · see citing works
Fretts, A. M., Howard, B. V., Siscovick, D. S., Best, L. G., Beresford, S. A. A., Méte, M., Eilat-Adar, S., Sotoodehnia, N., & Zhao, J. (2016) · Journal of Nutrition · doi:10.3945/jn.116.234922 · Cited by 43 · see citing works
Boeck, C., Gumpp, A. M., Calzia, E., Radermacher, P., Waller, C., Karabatsiakis, A., & Kolassa, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.040 · Cited by 40 · see citing works
Crack cocaine addiction, early life stress and accelerated cellular aging among women
Levandowski, M. L., Tractenberg, S. G., de Azeredo, L. A., Nardi, T. D., Rovaris, D. L., Bau, C. H. D., Rizzo, L. B., Maurya, P. K., Brietzke, E. M., Tyrka, A. R., et al. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.009 · Cited by 39 · see citing works
Self-citationWang, X., Sundquist, K., Rastkhani, H., Palmér, K., Memon, A. A., & Sundquist, J. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.06.001 · Cited by 39 · see citing works
Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder
Czarny, P. L., Wigner, P., Strycharz, J., Świderska, E., Synowiec, E., Szatkowska, M., Śliwińska, A., Talarowska, M. E., Szemraj, J., Su, K., et al. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1588993 · Cited by 38 · see citing works
Willis, M. M., Reid, S., Calvo, E., Staudinger, U. M., & Factor-Litvak, P. R. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.006 · Cited by 39 · see citing works
Humphreys, K. L., Sisk, L. M., Manczak, E. M., Lin, J., & Gotlib, I. H. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.09.031 · Cited by 37 · see citing works
Zhang, C., Mo, Y.-Y., Feng, S.-S., Meng, M., Chen, S., Huang, H., Xue, L., Song, H., Liang, Y., Ou, S., et al. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114338 · Cited by 37 · see citing works
Spano, L., Étain, B., Meyrel, M., Hennion, V., Gross, G., Laplanche, J., Bellivier, F., & Cynthia Marie-claire, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01891-4 · Cited by 37 · see citing works
Mitochondria, its DNA and telomeres in ageing and human population
Zole, E., & Ranka, R. (2018) · Biogerontology · doi:10.1007/s10522-018-9748-6 · Cited by 35 · see citing works
- Authors
- Tyrka, A. R., Parade, S. H., Price, L. H., Kao, H.-T., Porton, B., Philip, N. S., Welch, E. S., & Carpenter, L. L.
- Affiliations
- Brown University (US)
- Butler Hospital (US)
- Corresponding author
- Tyrka, Audrey R.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 79
- Issue
- 2
- Pages
- 78-86
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4503518
- OpenAlex
- W2049814665
- Cited by
- 259
- References
- 93
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 20 · 2023: 19 · 2022: 29 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 21 · 2017: 23 · 2016: 22 · 2015: 16
- FWCI
- 33.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21 MH091508, R01 MH068767-08S1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial DNA copy number, telomere length, childhood adversity, early life stress, child abuse, parental loss, psychopathology, major depressive disorder, anxiety disorders, substance use disorders, cellular aging, mitochondrial biogenesis
- MeSH terms
- Adolescent, Adult, Aging, Anxiety Disorders, Child Abuse, Major Depressive Disorder, Depressive Disorder, Major, DNA, Mitochondrial, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Stress, Psychological, Biomarkers, Cellular Senescence, Substance-Related Disorders, Young Adult, DNA Copy Number Variations, Telomere Shortening, Parental Death
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
