The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Leaching of endocrine disrupting chemicals from marine microplastics and mesoplastics under common life stress conditions
Open accessAbstract
Microplastics (MPs) and mesoplastics are able to sorb harmful substances and often contain additives, e.g., endocrine disrupting chemicals (EDCs), that can cause adverse effects to organisms. The present study aims to determine EDC concentrations and their endocrine activities in leachates of field-collected marine MPs and mesoplastics under stress conditions that are known to occur during the plastic life cycle. Estrogens were the dominant EDCs on plastic particles and were either concentrated from the surrounding water or originated from plastic manufacturing. Bisphenol A had the highest detection frequency (75%) with an average concentration of 475 ± 882 μg/kg, followed by bisphenol S, octylphenol and nonylphenol. Moreover, smaller marine MPs leached greater quantities of EDCs because the sorption from surrounding seawater is more efficient for smaller particles. It was found that normal life stresses such as microwaving (MW) and autoclaving (AC) can decrease EDC concentrations, but solar irradiation (solar) can increase EDC concentrations in leachates. Even though organisms with higher metabolic ability exhibited greater estrogenic effects, the comprehensive toxicity of plastic leachates after common life treatments was still limited (below the EC10 value) if 0.1% is taken as the EDC uptake from plastic. In future studies, the accurate contribution of plastic bound EDCs needs to be further explored, and the monitoring of MPs and mesoplastics in the human diet remains important because the concentrations of these plastics may change in the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Almost all plastic products are carriers of endocrine-disrupting chemicals (EDCs) [76], a wide range of substances, including pharmaceuticals, dioxin, and dioxin-like compounds; polychlorinated biphenyls; DDT and other pesticides; and components of plastics, such as BPA and phthalates.”
From Is Wild Marine Biota Affected by Microplastics? (2022) · cites this paper as [76]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Transport and release of chemicals from plastics to the environment and to wildlife
Teuten, E. L., Saquing, J. M., Knappe, D. R. U., Barlaz, M. A., Jonsson, S., Björn, A., Rowland, S. J., Thompson, R. C., Galloway, T. S., Yamashita, R., et al. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0284 · Cited by 2,938
Microplastics in bivalves cultured for human consumption
Cauwenberghe, L. V., & Janssen, C. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.06.010 · Cited by 2,105
Plastic Resin Pellets as a Transport Medium for Toxic Chemicals in the Marine Environment
Mato, Y., Isobe, T., Takada, H., Kanehiro, H., OHTAKE, C., & Kaminuma, T. (2000) · Environmental Science & Technology · doi:10.1021/es0010498 · Cited by 1,898
Evidence that the Great Pacific Garbage Patch is rapidly accumulating plastic
Lebreton, L., Slat, B., Ferrari, F., Sainte-Rose, B., Aitken, J., Marthouse, R., Hajbane, S., Cunsolo, S., Schwarz, A., Levivier, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22939-w · Cited by 1,839
Koelmans, A. A., Bakir, A., Burton, G. A., & Janssen, C. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b06069 · Cited by 1,667
Routledge, E. J., & Sumpter, J. P. (1996) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620150303 · Cited by 1,522
State-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Occurrence and effects of plastic additives on marine environments and organisms: A review
Hermabessière, L., Dehaut, A., Paul-Pont, I., Lacroix, C., Jézéquel, R., Soudant, P., & Duflos, G. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.05.096 · Cited by 1,368
Van Cauwenberghe, L., Claessens, M., Vandegehuchte, M. B., & Janssen, C. R. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.01.008 · Cited by 1,084
Adsorption of trace metals to plastic resin pellets in the marine environment
Holmes, L., Turner, A., & Thompson, R. C. (2011) · Environmental Pollution · doi:10.1016/j.envpol.2011.08.052 · Cited by 1,074
Ingestion of Microplastics by Zooplankton in the Northeast Pacific Ocean
Desforges, J.-P. W., Galbraith, M., & Ross, P. S. (2015) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-015-0172-5 · Cited by 1,019
A review on endocrine disruptors and their possible impacts on human health
Kabir, E. R., Rahman, M. S., & Rahman, I. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.06.009 · Cited by 945
The weight of nations: an estimation of adult human biomass
Walpole, S. C., Prieto‐Merino, D., Edwards, P. J., Cleland, J., Stevens, G. A., & Roberts, I. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-439 · Cited by 868
Alimba, C. G., & Faggio, C. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.03.001 · Cited by 863
Organic micropollutants in marine plastics debris from the open ocean and remote and urban beaches
Hirai, H., Takada, H., Ogata, Y., Yamashita, R., Mizukawa, K., Saha, M., Kwan, C. S., Moore, C. J., Gray, H. E., Laursen, D., et al. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.06.004 · Cited by 862
Nizzetto, L., Bussi, G., Futter, M. N., Butterfield, D., & Whitehead, P. G. (2016) · Environmental Science Processes & Impacts · doi:10.1039/c6em00206d · Cited by 850
Microplastic in marine organism: Environmental and toxicological effects
Guzzetti, E., Sureda, A., Tejada, S., & Faggio, C. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.10.009 · Cited by 833
Ten Years of Mixing Cocktails: A Review of Combination Effects of Endocrine-Disrupting Chemicals
Kortenkamp, A. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9357 · Cited by 664
Understanding the fragmentation pattern of marine plastic debris
ter Halle, A., Ladirat, L., Gendre, X., Goudouneche, D., Pusineri, C., Routaboul, C., Tenailleau, C., Duployer, B., & Perez, E. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00594 · Cited by 613
Endo, S., Takizawa, R., Okuda, K., Takada, H., Chiba, K., Kanehiro, H., Ogi, H., Yamashita, R., & Date, T. (2005) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2005.04.030 · Cited by 602
Rosenfeldt, E. J., & Linden, K. G. (2004) · Environmental Science & Technology · doi:10.1021/es035413p · Cited by 591
Le, H. H., Carlson, E. M., Chua, J. P., & Belcher, S. M. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.11.001 · Cited by 500
Chen, Q., Yin, D., Jia, Y., Schiwy, S., Legradi, J., Yang, S., & Hollert, H. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.144 · Cited by 484
Most Plastic Products Release Estrogenic Chemicals: A Potential Health Problem That Can Be Solved
Yang, C. Z., Yaniger, S. I., Jordan, V. C., Klein, D. J., & Bittner, G. D. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003220 · Cited by 432
Legler, J., Brink, C. E. V. D., Brouwer, A., Murk, A. J., van der Saag, P. T., Vethaak, A. D., & van der Burg, B. (1999) · Toxicological Sciences · doi:10.1093/toxsci/48.1.55 · Cited by 430
Plastic ingestion by mesopelagic fishes in the North Pacific Subtropical Gyre
Davison, P., & Asch, R. G. (2011) · Marine Ecology Progress Series · doi:10.3354/meps09142 · Cited by 426
Molina-Molina, J.-M., Amaya, E., Grimaldi, M., Sáenz, J.-M., Real, M., Fernández, M. F., Balaguer, P., & Olea, N. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.015 · Cited by 375
Microplastic Contamination in Aquatic Environments
Zeng, E. Y. (2018) · Elsevier eBooks · doi:10.1016/c2016-0-04784-8 · Cited by 373
Bisphenol A in the Aquatic Environment and Its Endocrine-Disruptive Effects on Aquatic Organisms
Kang, J., Aasi, D., & Katayama, Y. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440701493103 · Cited by 337
Leachates from plastic consumer products – Screening for toxicity with Daphnia magna
Lithner, D., Damberg, J., Dave, G., & Larsson, Å. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.11.022 · Cited by 325
Lohmann, R. (2011) · Environmental Science & Technology · doi:10.1021/es202702y · Cited by 325
Derivation and application of relative potency estimates based on in vitro bioassay results
Villeneuve, D. L., Blankenship, A. L., & Giesy, J. P. (2000) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620191131 · Cited by 275
Gooseneck barnacles ( Lepas spp.) ingest microplastic debris in the North Pacific Subtropical Gyre
Goldstein, M. C., & Goodwin, D. S. (2013) · PeerJ · doi:10.7717/peerj.184 · Cited by 262
Hydrophobic sorption behaviors of 17β-Estradiol on environmental microplastics
Liu, X., Xu, J., Zhao, Y., Shi, H., & Huang, C. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.03.162 · Cited by 220
Marine Microplastics: Abundance, Distribution, and Composition
Shim, W. J., Hong, S. H., & Eo, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813747-5.00001-1 · Cited by 219
Pollutants in Plastics within the North Pacific Subtropical Gyre
Chen, Q., Reisser, J., Cunsolo, S., Kwadijk, C. J. A. F., Kotterman, M. J. J., Proietti, M., Slat, B., Ferrari, F. F., Schwarz, A., Levivier, A., et al. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b04682 · Cited by 201
Bovee, T. F. H., Helsdingen, R. J. R., Rietjens, I. M. C. M., Keijer, J., & Hoogenboom, L. A. P. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.118 · Cited by 196
Determination of Steroidal Hormone Profiles along the Jalle d'Eysines River (near Bordeaux, France)
Labadie, P., & Budzinski, H. (2005) · Environmental Science & Technology · doi:10.1021/es048443g · Cited by 194
Savoca, S., Capillo, G., Mancuso, M., Bottari, T., Crupi, R., Branca, C., Romano, V., Faggio, C., D’Angelo, G., & Spanò, N. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.01.011 · Cited by 193
Sajiki, J., & Yonekubo, J. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00789-0 · Cited by 190
Seidensticker, S., Grathwohl, P., Lamprecht, J., & Zarfl, C. (2018) · Environmental Sciences Europe · doi:10.1186/s12302-018-0155-z · Cited by 190
Oehlmann, J., Oetken, M., & Schulte‐Oehlmann, U. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.016 · Cited by 179
Marine microplastics bound dioxin-like chemicals: Model explanation and risk assessment
Chen, Q., Zhang, H., Allgeier, A., Zhou, Q., Ouellet, J. D., Crawford, S. E., Luo, Y., Yang, Y., Shi, H., & Hollert, H. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.10.032 · Cited by 164
Bisphenol A, 4-tert-Octylphenol, and 4-Nonylphenol in The Gulf of Gdańsk (Southern Baltic)
Staniszewska, M., Falkowska, L. M., Grabowski, P., Kwaśniak, J., Mudrak-Cegiołka, S., Reindl, A. R., Sokołowski, A., Szumiło, E., & Zgrundo, A. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-014-0023-9 · Cited by 156
Migration of Nonylphenol from Plastic Containers to Water and a Milk Surrogate
Loyo-Rosales, J. E., Rosales-Rivera, G. C., Lynch, A. M., Rice, C. P., & Torrents, A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0345696 · Cited by 155
Floating plastics in Adriatic waters (Mediterranean Sea): From the macro- to the micro-scale
Zeri, C., Adamopoulou, A., Varezić, D. B., Fortibuoni, T., Viršek, M. K., Kržan, A., Mandić, M., Mazziotti, C., Palatinus, A., Peterlin, M., et al. (2018) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2018.09.016 · Cited by 140
Carballa, M., Omil, F., Alder, A. C., & Lema, J. M. (2006) · Water Science & Technology · doi:10.2166/wst.2006.241 · Cited by 131
Bittner, G. D., Yang, C. Z., & Stoner, M. A. (2014) · Environmental Health · doi:10.1186/1476-069x-13-41 · Cited by 129
Cao, X., & Corriveau, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800870b · Cited by 122
Human Risk Assessment of Endocrine‐Disrupting Chemicals Derived from Plastic Food Containers
Bang, D. Y., Kyung, M., Kim, M. J., Jung, B. Y., Cho, M. C., Choi, S. M., Kim, Y. W., Lim, S. K., Lim, D. S., Won, A. J., et al. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2012.00197.x · Cited by 115
Hibberd, A., Maskaoui, K., Zhang, Z., & Zhou, J. L. (2008) · Talanta · doi:10.1016/j.talanta.2008.09.006 · Cited by 112
Pillon, A., Boussioux, A., Escande, A., Aı̈t-Aı̈ssa, S., Góméz, E., Fenet, H., Ruff, M., Moras, D., Vignon, F., Duchesne, M., et al. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7522 · Cited by 111
Hamlin, H. J., Marciano, K., & Downs, C. A. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.06.032 · Cited by 101
Wölz, J., Engwall, M., Maletz, S., Takner, H. O., van Bavel, B., Kammann, U., Klempt, M., Weber, R., Braunbeck, T. A., & Hollert, H. (2008) · Environmental Science and Pollution Research · doi:10.1007/s11356-008-0056-6 · Cited by 99
Jantz, L. A., Morishige, C., Bruland, G. L., & Lepczyk, C. A. (2013) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2013.01.019 · Cited by 99
Maletz, S., Floehr, T., Beier, S., Klümper, C., Brouwer, A., Behnisch, P., Higley, E. B., Giesy, J. P., Hecker, M., Gebhardt, W., et al. (2012) · Water Research · doi:10.1016/j.watres.2012.12.008 · Cited by 95
Brinkmann, M., Maletz, S., Krauss, M. K. V., Bluhm, K., Schiwy, S., Kuckelkorn, J., Tiehm, A., Brack, W., & Hollert, H. (2014) · Environmental Science & Technology · doi:10.1021/es405731j · Cited by 82
Effect-based tools for monitoring estrogenic mixtures: Evaluation of five in vitro bioassays
Kunz, P. Y., Simon, E., Creusot, N., Jayasinghe, B. S., Kienle, C., Maletz, S., Schifferli, A., Schönlau, C., Aı̈t-Aı̈ssa, S., Denslow, N. D., et al. (2016) · Water Research · doi:10.1016/j.watres.2016.10.062 · Cited by 81
Estrogenic activity in Finnish municipal wastewater effluents
Välitalo, P., Perkola, N., Seiler, T., Sillanpää, M., Kuckelkorn, J., Mikola, A., Hollert, H., & Schultz, E. (2015) · Water Research · doi:10.1016/j.watres.2015.10.056 · Cited by 75
Scales of Dispersal and the Biogeography of Marine Predator‐Prey Interactions
Wieters, E. A., Gaines, S. D., Navarrete, S. A., Blanchette, C. A., & Menge, B. A. (2008) · The American Naturalist · doi:10.1086/527492 · Cited by 71
Bittner, G. D., Denison, M. S., Yang, C. Z., Stoner, M. A., & He, G. (2014) · Environmental Health · doi:10.1186/1476-069x-13-103 · Cited by 69
Evans, R., Scholze, M., & Kortenkamp, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043606 · Cited by 54
Hazardous Industrial Waste Treatment
Wang, L. K., Hung, Y., Lo, H. H., & Yapijakis, C. (2006) · CRC Press eBooks · doi:10.1201/9780849375750 · Cited by 53
Zhang, H., Yu, X., Yang, W., Peng, J., Xu, T., Yin, D., & Hu, X. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.08.036 · Cited by 52
Polovina, J. J., & Woodworth‐Jefcoats, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062341 · Cited by 50
Threats to human health by great ocean garbage patches
Efferth, T., & Paul, N. W. (2017) · The Lancet Planetary Health · doi:10.1016/s2542-5196(17)30140-7 · Cited by 48
Chen, I., Hsieh, T., Thomas, T., & Safe, S. H. (2001) · Gene · doi:10.1016/s0378-1119(00)00530-8 · Cited by 43
Hu, X., Peng, J., Liu, J., Jiang, G., & Jönsson, J. Å. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.07.028 · Cited by 28
Kuckelkorn, J., Redelstein, R., Heide, T., Kunze, J., Maletz, S., Waldmann, P., Grummt, T., Seiler, T., & Hollert, H. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0155-3 · Cited by 27
Hamid, H., & Eskicioğlu, Ç. (2013) · Water Research · doi:10.1016/j.watres.2013.05.042 · Cited by 21
Zerega, N. J. C. (2003) · Dialnet (Universidad de la Rioja) · Cited by 18
Yu, M., Tsunoda, H., & Tsunoda, M. (2016) · CRC Press eBooks · doi:10.1201/b11677 · Cited by 15
Research works printed but not linked: 1
- Moore, 2003, Trashed - across the pacific ocean, plastics, plastics, everywhere, Nat. Hist., 112, 46
Cited by
Sorted by citations
Huang, W., Song, B., Liang, J., Niu, Q., Zeng, G., Shen, M., Deng, J., Luo, Y., Wen, X., & Zhang, Y. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124187 · Cited by 823
Duan, J., Bolan, N. S., Li, Y., Ding, S., Atugoda, T., Vithanage, M. S., Sarkar, B., Tsang, D. C. W., & Kirkham, M. B. (2021) · Water Research · doi:10.1016/j.watres.2021.117011 · Cited by 667
Ali, S. S., Elsamahy, T., Koutra, E., Kornaros, M. E., El-Sheekh, M. M., Abdelkarim, E. A., Zhu, D., & Sun, J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144719 · Cited by 671
Microplastics in take-out food containers
Du, F., Cai, H., Zhang, Q., Chen, Q., & Shi, H. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122969 · Cited by 466
Characteristics of Plastic Pollution in the Environment: A Review
Li, P., Wang, X., Su, M., Zou, X., Duan, L., & Zhang, H. (2020) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-020-02820-1 · Cited by 495
Metadata
- Authors
- Chen, Q., Allgeier, A., Yin, D., & Hollert, H.
- Affiliations
- State Key Laboratory of Estuarine and Coastal Research (CN)
- RWTH Aachen University (DE)
- Tongji University (CN)
- Corresponding author
- Chen, Qiqing
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 130
- Pages
- 104938
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2950999644
- Cited by
- 304
- References
- 72
- Citations by year
- 2026: 26 · 2025: 45 · 2024: 54 · 2023: 48 · 2022: 56 · 2021: 42 · 2020: 31 · 2019: 2
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen)
- Funders
- International Science and Technology Cooperation Programme (2016YFE0123700)
- National Natural Science Foundation of China (21806038)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- endocrine disruptors, marine microplastics, mesoplastics, plastic leachates, estrogenic activity, bisphenol A, bisphenol S, octylphenol, nonylphenol, polymer additives, particle size effects, microwave heating, autoclaving, solar irradiation, plastic life cycle
- MeSH terms
- Adsorption, Cell Survival, Environmental Monitoring, Estrogens, Hot Temperature, Humans, Microwaves, Phenols, Plastics, Receptors, Estrogen, Seawater, Water Pollutants, Chemical, Yeasts, Cell Line, Tumor, Endocrine Disruptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
