Cited by 117Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactEnvironmental Toxicology and Ecotoxicology

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Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife

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Bangma, Jacqueline, Guillette, T.C., Bommarito, Paige A., Ng, Carla, Reiner, Jessica L., Lindstrom, Andrew B., Strynar, Mark J.·2022·Environment International

DOI 10.1016/j.envint.2021.107037PMC PMC8802192

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Abstract

Per- and polyfluoroalkyl substances (PFAS) accumulation and elimination in both wildlife and humans is largely attributed to PFAS interactions with proteins, including but not limited to organic anion transporters (OATs), fatty acid binding proteins (FABPs), and serum proteins such as albumin. In wildlife, changes in the biotic and abiotic environment (e.g. salinity, temperature, reproductive stage, and health status) often lead to dynamic and responsive physiological changes that alter the prevalence and location of many proteins, including PFAS-related proteins. Therefore, we hypothesize that if key PFAS-related proteins are impacted as a result of environmentally induced as well as biologically programmed physiological changes (e.g. reproduction), then PFAS that associate with those proteins will also be impacted. Changes in tissue distribution across tissues of PFAS due to these dynamics may have implications for wildlife studies where these chemicals are measured in biological matrices (e.g., serum, feathers, eggs). For example, failure to account for factors contributing to PFAS variability in a tissue may result in exposure misclassification as measured concentrations may not reflect average exposure levels. The goal of this review is to share general information with the PFAS research community on what biotic and abiotic changes might be important to consider when designing and interpreting a biomonitoring or an ecotoxicity based wildlife study. This review will also draw on parallels from the epidemiological discipline to improve study design in wildlife research. Overall, understanding these connections between biotic and abiotic environments, dynamic protein levels, PFAS levels measured in wildlife, and epidemiology serves to strengthen study design and study interpretation and thus strengthen conclusions derived from wildlife studies for years to come.

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Authors: Bangma, J., Guillette, T. C., Bommarito, P. A., Ng, C., Reiner, J. L., Lindstrom, A. B., & Strynar, M. J.
Affiliations: Oak Ridge Institute for Science and Education (US)
National Institute of Environmental Health Sciences (US)
University of Pittsburgh (US)
National Institute of Standards and Technology (US)
Environmental Protection Agency (US)
Corresponding author: Bangma, Jacqueline
ORCID: Bangma, Jacqueline
Guillette, T.C.
Bommarito, Paige A.
Ng, Carla
Reiner, Jessica L.
Lindstrom, Andrew B.
Strynar, Mark J.
Venue: Environment International
Publisher: Elsevier BV
Published: 2022-01
Volume: 159
Pages: 107037
ISSN: 0160-4120 (ISSN-L)
DOI: 10.1016/j.envint.2021.107037
PMC: PMC8802192
OpenAlex: W4200086124
Cited by: 117
References: 142
Citations by year: 2026: 28 · 2025: 33 · 2024: 28 · 2023: 23 · 2022: 5
FWCI: 1.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/3.0/igo/ (vor)
Locations: Environment International (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords: per- and polyfluoroalkyl substances, PFAS, wildlife, protein expression, physiological changes, organic anion transporters, fatty acid binding protein, serum albumin, tissue distribution, exposure misclassification, biomonitoring, ecotoxicology, research design, reproductive stage, salinity, temperature
MeSH terms: Biological Monitoring, Animals, Animals, Wild, Fluorocarbons, Humans, Reproduction, Alkanesulfonic Acids

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Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife

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