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Cited by 11Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersToxic Organic Pollutants Impact

Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study

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Özel, Fatih, Stratmann, Marlene, Lindh, Christian, Gennings, Chris, Bornehag, Carl-Gustaf, Rüegg, Joëlle·2023·Environment International
DOI 10.1016/j.envint.2023.108029
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Abstract

BACKGROUND: A growing body of evidence shows that prenatal exposure to phthalates affects child development. Since many phthalates have been shown to alter endocrine signaling, they may influence reproductive development, neurodevelopment, and child behavior. Indeed, a few studies reported associations between prenatal phthalate exposure and gender-specific play behavior. However, evidence for this relationship is limited, and previous findings are based on single phthalates, while human exposure entails mixtures of chemicals. OBJECTIVE: We aimed to investigate the associations between prenatal exposure to single phthalates, as well as a phthalate mixture, and gender-specific play behavior. METHODS: A total of 715 mother-child pairs from the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy (SELMA) study were included. In the median week 10 of pregnancy, phthalate metabolites were measured in urine. Gender-specific play behavior was measured with Preschool Activities Inventory at the age of seven years. Linear and weighted quantile sum regressions were used; data was stratified by sex. Models were adjusted for child and maternal age, maternal education, parental attitudes toward play behavior, and urinary creatinine concentration. RESULTS: For boys, single compound analyses revealed negative associations of prenatal exposure to di-isononyl phthalate (DINP) concentrations with masculine (β = -1.44; 95% CI = -2.72, -0.16) and composite (β = -1.43; 95% CI = -2.72, -0.13) scores. Suggestive associations were also observed with a mixture approach identifying DINP as the main contributor of the association of decreased masculine play. Among girls, higher urinary concentrations of 2,4-methyl-7-oxyooctyl-oxycarbonyl-cyclohexane carboxylic acid (MOiNCH) was associated with decreased feminine (β = -1.59; 95% CI = -2.62, -0.57) and masculine scores (β = -1.22; 95% CI = -2.14, -0.29), whereas the mixture analyses did not yield conclusive results for girls. CONCLUSION: Our findings suggest associations of prenatal exposure to DINP with decreased masculine play behavior in boys while the results for girls were not fully conclusive.

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Cited by

Sorted by citations

Authors
Özel, F., Stratmann, M., Lindh, C., Gennings, C., Bornehag, C.-G., & Rüegg, J.
Affiliations
  • Uppsala University (SE)
  • Karlstad University (SE)
  • Lund University (SE)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Özel, Fatih
ORCID
Venue
Environment International
Publisher
Elsevier BV
Published
2023-08
Volume
178
Pages
108029
ISSN
0160-4120 (ISSN-L)
DOI
10.1016/j.envint.2023.108029
OpenAlex
W4380786249
Cited by
11
References
1
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2023: 1
FWCI
1.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Environment International (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Diva portal (Dalarna University Library) (submittedVersion, other-oa)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Vårdalstiftelsen
  • European Commission (HORIZON2020, 634880)
  • Svenska Forskningsrådet Formas
  • Vetenskapsrådet
  • Landstinget i Värmland
  • Astma- och Allergiförbundet
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
prenatal phthalate exposure, diisononyl phthalate, phthalate mixtures, urinary phthalate metabolites, endocrine disruptors, child development
MeSH terms
Asthma, Child, Child, Preschool, Environmental Exposure, Environmental Pollutants, Female, Humans, Hypersensitivity, Male, Phthalic Acids, Pregnancy, Prenatal Exposure Delayed Effects, Sweden, Environmental Illness

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