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Cited by 50Air Quality and Health ImpactsNeuroinflammation and Neurodegeneration MechanismsImmunotoxicology and immune responses

In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice

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Kulas, Joshua A., Hettwer, Jordan V., Sohrabi, Mona, Melvin, Justine E., Manocha, Gunjan D., Puig, Kendra L., Gorr, Matthew W., Tanwar, Vineeta +3 more·2018·Environmental Pollution
DOI 10.1016/j.envpol.2018.05.047PMC PMC6082156
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Abstract

Environmental exposure to air pollution has been linked to a number of health problems including organ rejection, lung damage and inflammation. While the deleterious effects of air pollution in adult animals are well documented, the long-term consequences of particulate matter (PM) exposure during animal development are uncertain. In this study we tested the hypothesis that environmental exposure to PM 2.5 μm in diameter in utero promotes long term inflammation and neurodegeneration. We evaluated the behavior of PM exposed animals using several tests and observed deficits in spatial memory without robust changes in anxiety-like behavior. We then examined how this affects the brains of adult animals by examining proteins implicated in neurodegeneration, synapse formation and inflammation by western blot, ELISA and immunohistochemistry. These tests revealed significantly increased levels of COX2 protein in PM2.5 exposed animal brains in addition to changes in synaptophysin and Arg1 proteins. Exposure to PM2.5 also increased the immunoreactivity for GFAP, a marker of activated astrocytes. Cytokine concentrations in the brain and spleen were also altered by PM2.5 exposure. These findings indicate that in utero exposure to particulate matter has long term consequences which may affect the development of both the brain and the immune system in addition to promoting inflammatory change in adult animals.

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  • Increased expression of glial fibrillary acidic protein has consistently been correlated with developmental PM2.5 and PM0.1 exposure.

    “Increased expression of the glial fibrillary acidic protein (GFAP), a marker of activated astrocytes, has consistently been correlated with developmental PM2.5 and PM0.1 exposure [113, 114].”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [114]

    The Results report significantly increased astrocyte GFAP staining in adult mice exposed to PM2.5 in utero. They also report no significant increase in total GFAP by western blot. This paper does not establish a consistent increase in GFAP expression or address developmental PM0.1 exposure. (LLM, conf=0.88)

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Cited by

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Authors
Kulas, J. A., Hettwer, J. V., Sohrabi, M., Melvin, J. E., Manocha, G. D., Puig, K. L., Gorr, M. W., Tanwar, V., McDonald, M. P., Wold, L. E., & Combs, C. K.
Affiliations
  • University of North Dakota (US)
  • The Ohio State University (US)
  • University of Tennessee Health Science Center (US)
Corresponding author
Combs, Colin K.
ORCID
Venue
Environmental Pollution
Publisher
Elsevier BV
Published
2018-10
Volume
241
Pages
279-288
ISSN
0269-7491 (ISSN-L)
DOI
10.1016/j.envpol.2018.05.047
PMC
PMC6082156
OpenAlex
W2804425499
Cited by
50
References
8
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 3 · 2018: 1
FWCI
2.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Pollution (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (5R01AG042819, 5R01ES019923, R01AG057046)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
prenatal exposure, PM2.5, air pollution, neuroinflammation, neurodegeneration, spatial memory impairment, anxiety-like behavior, cyclooxygenase-2, synaptophysin, arginase-1, glial fibrillary acidic protein, astrocyte activation, cytokines, brain development
MeSH terms
Adult, Air Pollutants, Air Pollution, Animals, Anxiety, Behavior, Animal, Brain, Environmental Exposure, Humans, Male, Nervous System, Phenotype, Biomarkers, Toxicity Tests, Mice, Particulate Matter

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