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Cited by 107Effects and risks of endocrine disrupting chemicalsSperm and Testicular FunctionSexual Differentiation and Disorders

Prenatal phthalate exposure and reproductive function in young men

Axelsson, Jonatan, Rylander, Lars, Rignell-Hydbom, Anna, Lindh, Christian H., Jönsson, Bo A.G., Giwercman, Aleksander·2015·Environmental Research
DOI 10.1016/j.envres.2015.02.024
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Abstract

Background Prenatal exposure to phthalates is suggested to negatively impact male reproductive function, but human data are lacking. Objectives To study associations between prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP), and reproductive parameters of adolescent men. Methods Using linear regression models adjusted for potential confounders, we studied associations between levels of DEHP- and DiNP metabolites in maternal sera from mean 12 weeks of pregnancy, and testicular size, semen quality and reproductive hormones in 112 adolescent sons, recruited from the general population. Results Men in the highest exposure tertile of one DiNP metabolite [mono-(carboxy-iso-octyl) phthalate], compared with men in the lowest tertile had: 4.3mL (95% CI: 0.89, 7.6mL; p Conclusion Prenatal levels of some metabolites of DEHP and DiNP seemed negatively associated with reproductive function of adolescent men.

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Crossref · 10.1016/j.envres.2015.02.024

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  • Cotinine was analysed using liquid chromatography tandem mass spectrometry with a limit of detection of 0.4 ng/ml and a coefficient of variation of 2% at 48 ng/ml, as part of a quality control program.

    “Cotinine was analysed in the urine samples from 396 of the men, using liquid chromatography tandem mass spectrometry (LC–MS/MS; QTRAP5500, AB Sciex, Framingham, MA, USA) with a modified serum method 20 , 21 at the Division of Occupational and Environmental Medicine at Lund University. The limit of detection was 0.4 ng/ml, and the coefficient of variation at 48 ng/ml was 2%. The analysis of cotinin”

    From Decreased sperm counts in Swedish users of oral tobacco (2022) · cites this paper as [20]

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Authors
Axelsson, J., Rylander, L., Rignell-Hydbom, A., Lindh, C. H., Jönsson, B. A. G., & Giwercman, A.
Affiliations
Lund University (SE)
Corresponding author
Axelsson, Jonatan
ORCID
Venue
Environmental Research
Publisher
Elsevier BV
Published
2015-04
Volume
138
Pages
264-270
ISSN
0013-9351 (ISSN-L)
DOI
10.1016/j.envres.2015.02.024
OpenAlex
W1996506430
Cited by
107
References
8
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 12 · 2019: 13 · 2018: 11 · 2017: 5 · 2016: 4
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environmental Research (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
prenatal phthalate exposure, DEHP, diisononyl phthalate, phthalate metabolites, male reproductive function, adolescent boys, testicular volume, semen quality, follicle-stimulating hormone, luteinizing hormone, reproductive hormones, endocrine disruptors
MeSH terms
Adolescent, Diethylhexyl Phthalate, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Female, Humans, Male, Phthalic Acids, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Gonadal Steroid Hormones, Sweden, Testis, Semen Analysis, Young Adult

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