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Cited by 66Effects and risks of endocrine disrupting chemicalsSperm and Testicular FunctionPesticide Exposure and Toxicity

Preconception seminal plasma concentrations of endocrine disrupting chemicals in relation to semen quality parameters among male partners planning for pregnancy

Smarr, Melissa M., Kannan, Kurunthachalam, Sun, Liping, Honda, Masato, Wang, Wei, Karthikraj, Rajendiran, Chen, Zhen, Weck, Jennifer +1 more·2018·Environmental Research
DOI 10.1016/j.envres.2018.07.004
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Abstract

Background Some non-persistent endocrine disruptors (EDCs) are adversely associated with semen quality and few studies have measured those EDCs in seminal plasma. Objective To find an association between EDCs in seminal plasma and semen quality parameters. Methods Five chemical classes of non-persistent EDCs were quantified in seminal plasma from 339 male partners who participated in a prospective pregnancy study. Bisphenols, benzophenone UV-filters, antimicrobials and phthalate diesters and their monoester metabolites were measured using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Semen samples underwent next day analysis using a standardized protocol for the quantification of 35 endpoints. Linear mixed-effects models of EDCs that were log transformed and rescaled by their standard deviations or dichotomized at the 75th percentile for each exposure and outcomes with covariate adjustment were performed. EDCs in seminal plasma were also assessed relative to clinical reference values of semen quality endpoints using logistic regression or generalized estimating equations. Results The most consistent findings supporting adverse associations between seminal EDCs and semen quality were observed for some phthalate metabolites. For example, seminal plasma mono-ethyl, mono-n-butyl, mono-2-isobutyl and mono-benzyl phthalate concentrations were associated with decreased odds of having semen volume above clinical reference va…

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  • DEHP (2.09 μg/L) and DBP (1.75 μg/L), as well as their metabolites, were found as the predominant phthalates/phthalate metabolites in seminal plasma from male partners who were planning for pregnancy.

    “Similarly, DEHP (2.09 µg/L) and DBP (1.75 µg/L), as well as their metabolites, were found as the predominant phthalates/phthalate metabolites in seminal plasma from male partners who were planning for pregnancy.”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [163]

  • Adverse associations were shown between seminal phthalate metabolite concentrations and semen quality.

    “This study showed adverse associations between seminal phthalate metabolite concentrations and semen quality [163].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [163]

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Authors
Smarr, M. M., Kannan, K., Sun, L., Honda, M., Wang, W., Karthikraj, R., Chen, Z., Weck, J., & Buck Louis, G. M.
Affiliations
  • National Institutes of Health (US)
  • New York State Department of Health (US)
  • Glotech (United States) (US)
Corresponding author
Smarr, Melissa M.
ORCID
Venue
Environmental Research
Publisher
Elsevier BV
Published
2018-11
Volume
167
Pages
78-86
ISSN
0013-9351 (ISSN-L)
DOI
10.1016/j.envres.2018.07.004
OpenAlex
W2861401089
Cited by
66
References
6
Citations by year
2026: 5 · 2025: 6 · 2024: 5 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 2
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environmental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Child Health and Human Development (N01-HD-3–3355, N01-HD-3–3356, NOH-HD-3–3358, HHSN275201100001I)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords
endocrine disruptors, seminal plasma, semen quality, phthalate metabolites, bisphenols, benzophenone UV filters, antimicrobial agents, preconceptions, male fertility, semen volume, sperm motility, sperm viability, sperm morphology, pregnancy planning
MeSH terms
Humans, Male, Phthalic Acids, Prospective Studies, Semen, Sperm Head, Sperm Motility, Spermatozoa, Endocrine Disruptors, Semen Analysis

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