The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease
Abstract
Alzheimer's disease, a progressive neurological condition, is associated with various internal and external risk factors in the disease's early stages. Early diagnosis of Alzheimer's disease is essential for treatment management. Circulating exosomal microRNAs could be a new class of valuable biomarkers for early Alzheimer's disease diagnosis. Different kinds of biosensors have been introduced in recent years for the detection of these valuable biomarkers. Isolation of the exosomes is a crucial step in the detection process which is traditionally carried out by multi-step ultrafiltration. Microfluidics has improved the efficiency and costs of exosome isolation by implementing various effects and forces on the nano and microparticles in the microchannels. This paper reviews recent advancements in detecting Alzheimer's disease related exosomal microRNAs based on methods such as electrochemical, fluorescent, and SPR. The presented devices' pros and cons and their efficiencies compared with the gold standard methods are reported. Moreover, the application of microfluidic devices to detect Alzheimer's disease related biomarkers is summarized and presented. Finally, some challenges with the performance of novel technologies for isolating and detecting exosomal microRNAs are addressed.
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“Interestingly, even more exosome-derived miRNA detection methods were developed by the most recent technologies, to optimize the sensitivity and minimize the costs of detection [64].”
From miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia (2025) · cites this paper as [64]
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Cited by
Manzini, V., Cappelletti, P., Orefice, N. S., Brentari, I., Rigby, M. J., Lo Giudice, M., Feligioni, M., Rivabene, R., Crestini, A., Manfredi, F., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04386-z · Cited by 16
Metadata
- Authors
- Pishbin, E., Sadri, F., Dehghan, A., Kiani, M. J., Hashemi, N., Zare, I., Mousavi, P., & Rahi, A.
- ORCID
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 227
- Pages
- 115705
- ISSN
- 0013-9351
- Cited by
- 25
- References
- 112
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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- Pishbin, E., Sadri, F., Dehghan, A., Kiani, M. J., Hashemi, N., Zare, I., Mousavi, P., & Rahi, A. (2023). Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease. Environmental Research. https://doi.org/10.1016/j.envres.2023.115705
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