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Cited by 926Microfluidic and Bio-sensing TechnologiesAcoustic Wave Resonator TechnologiesMicrofluidic and Capillary Electrophoresis Applications

Surface acoustic wave microfluidics

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Ding, Xiaoyun, Li, Peng, Lin, Sz-Chin Steven, Stratton, Zackary S., Nama, Nitesh, Guo, Feng, Slotcavage, Daniel, Mao, Xiaole +3 more·2013·Lab on a Chip
DOI 10.1039/c3lc50361ePMC PMC3992948
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Abstract

The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle manipulation, and compatibility with other microfluidic components. We believe that these advantages enable SAW microfluidics to play a significant role in a variety of applications in biology, chemistry, engineering and medicine. In this review article, we discuss the theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended. We then review the SAW-enabled microfluidic devices demonstrated to date, starting with devices that accomplish fluid mixing and transport through the use of travelling SAW; we follow that by reviewing the more recent innovations achieved with standing SAW that enable such actions as particle/cell focusing, sorting and patterning. Finally, we look forward and appraise where the discipline of SAW microfluidics could go next.

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  • Acoustofluidic devices can assemble randomly distributed cells into numbers of 3D cell aggregates within minutes in a contact-free and label-free manner.

    “First of all, acoustofluidic devices can assemble randomly distributed cells into numbers of 3D cell aggregates within minutes in a contact-free and label-free manner.28”

    From Acoustofluidic assembly of 3D neurospheroids to model Alzheimer's disease (2020) · cites this paper as [28]

    Section 3.2.4 (page not provided) describes non-contact acoustic patterning of particles and cells into lines or arrays. It does not establish that randomly distributed cells form multiple 3D aggregates within minutes, or explicitly describe the process as label-free. The Introduction (page not provided) also characterizes SAW manipulation as contact-free. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Ding, X., Li, P., Lin, S.-C. S., Stratton, Z. S., Nama, N., Guo, F., Slotcavage, D., Mao, X., Shi, J., Costanzo, F., & Huang, T. J.
Affiliations
Pennsylvania State University (US)
Corresponding author
Huang, Tony Jun
ORCID
Venue
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Published
2013
Volume
13
Issue
18
Pages
3626
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
DOI
10.1039/c3lc50361e
PMC
PMC3992948
OpenAlex
W2162290466
Cited by
926
References
0
Citations by year
2026: 49 · 2025: 73 · 2024: 65 · 2023: 80 · 2022: 90 · 2021: 93 · 2020: 86 · 2019: 71 · 2018: 69 · 2017: 69 · 2016: 72 · 2015: 57 · 2014: 42 · 2013: 10
FWCI
5.64
Type
journal article
Language
en
Open access
Locations
  • Lab on a Chip (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (1dp2od007209-01)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
  • Physical Sciences › Engineering › Biomedical Engineering › Acoustic Wave Resonator Technologies
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
surface acoustic waves, fluid mixing, fluid transport, particle focusing, cell sorting, particle patterning
MeSH terms
Cell Separation, Humans, Models, Theoretical, Sound, Nanotubes, Carbon, Microfluidics, Liquid Crystals

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