miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia
Open accessAbstract
Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer’s disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT and AD patients. Increased levels of the same miRNAs were found also in CSF derived from FTD group compared to CTs. No differences were observed in expression levels of miR-320b among the three groups. Worthy of note, all miRNAs analysed were increased in an FTD cell model, MAPT IVS10 + 16 neurons. Our results suggest that miR-92a and miR-320a in NDEVs could be proposed as FTD biomarkers.
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Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works
Andersen, C. L., Jensen, J. L., & Ørntoft, T. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0496 · Cited by 7,127 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477087 · Cited by 2,773 · see citing works
Tau in physiology and pathology
Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, É., Pap, E., Kittel, Á., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0689-3 · Cited by 2,075 · see citing works
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284 · see citing works
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,135 · see citing works
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works
Characterization of human plasma-derived exosomal RNAs by deep sequencing
Huang, X., Yuan, T., Tschannen, M., Sun, Z., Jacob, H. J., Du, M., Liang, M., Dittmar, R. L., Liu, Y. U., Liang, M., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-319 · Cited by 1,046 · see citing works
Exosomes are released by cultured cortical neurones
Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896 · see citing works
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737 · see citing works
Frontotemporal Lobar Degeneration
Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 504 · see citing works
Mustapić, M., Eitan, E., Werner, J. K., Berkowitz, S. T., Lazaropoulos, M. P., Tran, J., Goetzl, E. J., & Kapogiannis, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00278 · Cited by 453 · see citing works
Lugli, G., Cohen, A. M., Bennett, D. A., Shah, R. C., Fields, C. J., Hernandez, A. G., & Smalheiser, N. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139233 · Cited by 423 · see citing works
Extracellular vesicles as mediators of neuron-glia communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., & Krämer‐Albers, E. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00182 · Cited by 383 · see citing works
Circulating miRNAs: cell–cell communication function?
Turchinovich, A. A., Samatov, T. R., Tonevitsky, A., & Burwinkel, B. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00119 · Cited by 370 · see citing works
Emerging Roles of Extracellular Vesicles in the Nervous System
Rajendran, L., Bali, J., Barr, M. M., Court, F. A., Krämer-Albers, E.-M., Picou, F., Raposo, G., van der Vos, K. E., van Niel, G., Wang, J., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3258-14.2014 · Cited by 259 · see citing works
Yang, T., Liu, C. G., Gao, S. C., Zhang, Y., & Wang, P. C. (2018) · PubMed · doi:10.3967/bes2018.011 · Cited by 230 · see citing works
Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases
Janas, A., Sapoń, K., Janas, T., Stowell, M. H. B., & Janas, T. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.02.011 · Cited by 226 · see citing works
Goetzl, E. J., Abner, E. L., Jicha, G. A., Kapogiannis, D., & Schwartz, J. B. (2018) · The FASEB Journal · doi:10.1096/fj.201700731r · Cited by 219 · see citing works
Li, Y., He, X., Li, Q., Lai, H., Zhang, H., Hu, Z., Li, Y., & Huang, S. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.002 · Cited by 193 · see citing works
Oligodendrocytes support axonal transport and maintenance via exosome secretion
Frühbeis, C., Kuo, W. P., Müller, C., Barth, K., Peris, L., Tenzer, S., Möbius, W., Werner, H. B., Nave, K., Fröhlich, D., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000621 · Cited by 193 · see citing works
Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics
Verheijen, J., & Sleegers, K. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.02.007 · Cited by 189 · see citing works
Circulating miRNAs as Biomarkers for Neurodegenerative Disorders
Grasso, M., Piscopo, P., Confaloni, A., & Denti, M. (2014) · Molecules · doi:10.3390/molecules19056891 · Cited by 187 · see citing works
Self-citationNon-coding RNAs in Alzheimer's Disease
Tan, L., Yu, J.-T., Hu, N., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8359-5 · Cited by 171 · see citing works
Extracellular Vesicles in Blood: Sources, Effects, and Applications
Alberro, A., Iparraguirre, L., Fernandes, A. M. A., & Otaegui, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158163 · Cited by 168 · see citing works
Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases
D’Anca, M., Fenoglio, C., Serpente, M., Arosio, B., Cesari, M., Scarpini, E. A., & Galimberti, D. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00232 · Cited by 156 · see citing works
Immunomodulatory role of microRNAs transferred by extracellular vesicles
Fernández‐Messina, L., Gutiérrez‐Vázquez, C., Rivas‐García, E., Sánchez‐Madrid, F., & de la Fuente, H. (2015) · Biology of the Cell · doi:10.1111/boc.201400081 · Cited by 152 · see citing works
Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135 · see citing works
Frontotemporal Lobar Degeneration: Epidemiology, Pathology, Diagnosis and Management
Seltman, R. E., & Matthews, B. R. (2012) · CNS Drugs · doi:10.2165/11640070-000000000-00000 · Cited by 132 · see citing works
Tau protein in neurodegenerative diseases - a review.
Pîrșcoveanu, D. F. V., Pirici, I., Tudorică, V., Bălşeanu, T. A., Albu, V. C., Bondari, S., Bumbea, A. M., & Pîrșcoveanu, M. (2017) · PubMed · Cited by 121 · see citing works
Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
Ciregia, F., Urbani, A., & Palmisano, G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00276 · Cited by 110 · see citing works
Cheng, L., Vella, L. J., Barnham, K. J., McLean, C., Masters, C. L., & Hill, A. F. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1766822 · Cited by 95 · see citing works
Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia
Wei, H., Xu, Y., Xu, W., Zhou, Q., Chen, Q., Yang, M., Feng, F., Liu, Y., Zhu, X., Yu, M., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.016 · Cited by 92 · see citing works
Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
Hedl, T. J., San Gil, R., Cheng, F., Rayner, S. L., Davidson, J. M., De Luca, A., Villalva, M. D., Ecroyd, H., Walker, A. K., & Lee, A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00548 · Cited by 87 · see citing works
Verheyen, A., Diels, A., Reumers, J., Hoorde, K. V., den Wyngaert, I. V., d’Ydewalle, C. V. O., Bondt, A. D., Kuijlaars, J., Muynck, L. D., Hoogt, R. D., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.022 · Cited by 66 · see citing works
Piscopo, P., Grasso, M., Puopolo, M., D’Acunto, E., Talarico, G., Crestini, A., Gasparini, M., Campopiano, R., Gambardella, S., Castellano, A. E., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180364 · Cited by 64 · see citing works
Self-citationDownregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study
Schneider, R., McKeever, P. M., Kim, T. P., Graff, C., Swieten, J. C. V., Karydas, A., Boxer, A. L., Rosen, H. J., Miller, B. L., Laforce, R. J., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317492 · Cited by 63 · see citing works
miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role
Yang, Q., Zhao, Q., & Yin, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7855 · Cited by 58 · see citing works
Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects
Grasso, M., Piscopo, P., Talarico, G., Ricci, L., Crestini, A., Tosto, G., Gasparini, M., Bruno, G., Denti, M. A., & Confaloni, A. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.024 · Cited by 55 · see citing works
Self-citationAltered Extracellular Vesicle miRNA Profile in Prodromal Alzheimer’s Disease
Visconte, C., Fenoglio, C., Serpente, M., Muti, P. C., Sacconi, A., Rigoni, M., Arighi, A., Borracci, V., Arcaro, M., Arosio, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914749 · Cited by 54 · see citing works
Frontotemporal dementia: a review for primary care physicians.
Cardarelli, R., KERTESZ, A. E., & Knebl, J. A. (2010) · PubMed · Cited by 53 · see citing works
del Campo, M., Zetterberg, H., Gandy, S., Onyike, C. U., Oliveira, F., Udeh‐Momoh, C., Lleó, A., Teunissen, C. E., & Pijnenburg, Y. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12643 · Cited by 52 · see citing works
Yuen, S. C., Liang, X., Zhu, H., Jia, Y., & Leung, S.-W. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00862-z · Cited by 42 · see citing works
Ryu, I. S., Kim, D. H., Ro, J.-Y., Park, B., Kim, S. H., Im, J.-Y., Lee, J., Yoon, S. J., Kang, H., Iwatsubo, T., et al. (2023) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2023.110603 · Cited by 42 · see citing works
Tallon, C., Picciolini, S., Yoo, S., Thomas, A. G., Pal, A., Alt, J., Carlomagno, C., Gualerzi, A., Rais, R., Haughey, N. J., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114796 · Cited by 41 · see citing works
Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer’s Disease
Arora, T., Prashar, V., Singh, R., Barwal, T. S., Changotra, H., Sharma, A., & Parkash, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02950-z · Cited by 35 · see citing works
Song, S., Lee, J. U., Jeon, M. J., Kim, S., Lee, C., & Sim, S. J. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115269 · Cited by 33 · see citing works
Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease
Avalos, J. A. J., Fernández-Macías, J. C., & González-Palomo, A. K. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-06050-w · Cited by 32 · see citing works
Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an update
Oeckl, P., Steinacker, P., Feneberg, E., & Otto, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13669 · Cited by 30 · see citing works
Precision Medicine for Frontotemporal Dementia
Liu, M., Lau, C. I., & Lin, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00075 · Cited by 30 · see citing works
Frontotemporal Lobar Degeneration and MicroRNAs
Piscopo, P., Albani, D., Castellano, A. E., Forloni, G., & Confaloni, A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00017 · Cited by 29 · see citing works
Self-citationPiscopo, P., Grasso, M., Fontana, F., Crestini, A., Puopolo, M., Vescovo, V. D., Venerosi, A., Calamandrei, G., Vencken, S. F., Greene, C. M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00031 · Cited by 29 · see citing works
Self-citationSmall Extracellular Vesicles’ miRNAs: Biomarkers and Therapeutics for Neurodegenerative Diseases
Lim, W. Q., Luk, K. H. M., Lee, K. Y., Nurul, N., Loh, S. J., Yeow, Z. X., Wong, Q. X., Looi, Q. H., Chong, P. P., How, C. W., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041216 · Cited by 28 · see citing works
Kopach, O., Esteras, N., Wray, S., Rusakov, D. A., & Abramov, A. Y. (2020) · Journal of Cell Science · doi:10.1242/jcs.241687 · Cited by 27 · see citing works
Kopach, O., Esteras, N., Wray, S., Abramov, A. Y., & Rusakov, D. A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04007-w · Cited by 26 · see citing works
Pounders, J., Hill, E. J., Hooper, D., Zhang, X., Biesiada, J., Kuhnell, D., Greenland, H. L., Esfandiari, L., Timmerman, E., Foster, F., et al. (2022) · Medicine · doi:10.1097/md.0000000000030854 · Cited by 26 · see citing works
Piscopo, P., Manzini, V., Rivabene, R., Crestini, A., Pera, L. L., Pizzi, E., Veroni, C., Talarico, G., Peconi, M., Castellano, A. E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113232 · Cited by 26 · see citing works
Self-citationRecent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease
Pishbin, E., Sadri, F., Dehghan, A., Kiani, M. J., Hashemi, N., Zare, I., Mousavi, P., & Rahi, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115705 · Cited by 25 · see citing works
Recent Advances in Frontotemporal Dementia
Tartaglia, M. C., & Mackenzie, I. R. (2022) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2022.69 · Cited by 24 · see citing works
Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease
Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 21 · see citing works
Piscopo, P., Grasso, M., Manzini, V., Zeni, A., Castelluzzo, M., Fontana, F., Talarico, G., Castellano, A. E., Rivabene, R., Crestini, A., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1127163 · Cited by 14 · see citing works
Self-citationCappelletti, P., Filareti, M., Masuelli, L., Bei, R., Hassanzadeh, K., Corbo, M., & Feligioni, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-18719-2 · Cited by 12 · see citing works
Self-citationZeni, A., Grasso, M., & Denti, M. A. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1851-6_11 · Cited by 4 · see citing works
Self-citationVincent, B. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103961 · Cited by 3 · see citing works
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Petracci, I., Bellini, S., Goljanek‐Whysall, K., Quinlan, L. R., Fiszer, A., Cakmak, A., Njume, C. M., Borroni, B., & Ghidoni, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073399 · Cited by 14 · see citing works
Zaman, A., Drake, S., & Fournier, A. E. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70323 · Cited by 13 · see citing works
Serpente, M., Delvecchio, G., Fenoglio, C., Consoli, L. D., Giudici, G., Borracci, V., Rotondo, E., Arcaro, M., Sacchi, L., Pintus, M., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106867 · Cited by 7 · see citing works
Wang, K., Yang, L., Zhang, C., Xing, X., Su, Z. G., Gao, P., & Han, B. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04626-1 · Cited by 5 · see citing works
Role of CPEBs in Learning and Memory
Hicks, D. A., Aubrey, L. D., Kwok, J. C. F., & Radford, S. E. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70226 · Cited by 4 · see citing works
Giudici, G., Fenoglio, C., Serpente, M., Arighi, A., Arcaro, M., Delvecchio, G., Brambilla, P., Sacchi, L., Pintus, M., Borracci, V., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107132 · Cited by 3 · see citing works
Clinical value of high‐frequency ultrasound and serum miR ‐92a‐3p in diabetic peripheral neuropathy
Qiao, C., Liu, Z. J., Wang, B., Wang, X., Zhao, Z., Wang, H., & Wang, X. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.70110 · Cited by 2 · see citing works
Elyasi, L., & Wężyk, M. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119001 · Cited by 2 · see citing works
Carbone, E., Zingaropoli, M. A., Perrone, F., Talarico, G., Pasculli, P., Minni, A., Petrella, C., Barbato, C., & Piscopo, P. (2026) · Cells · doi:10.3390/cells15060503 · Cited by 2 · see citing works
Self-citationXiao, J. N., & Zhu, J. F. (2026) · Neuroreport · doi:10.1097/wnr.0000000000002274 · Cited by 1 · see citing works
Exosomal miRNA in cerebrospinal fluid as biomarkers for neurodegenerative disease
Alamri, M. A., Afzal, M. Z., Pandey, S. N., Afzal, O., Akela, M. A., & Rekha, A. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.121094
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Pereira, J. D., Silva, L. C. B., Ozawa, M., Tosatti, J. A. G., LIMA, S. P. D. O., Silva, I. R., Jeunon, V. R., Ferriani, M. D. G. C., Resende, E., de Souza, L. C., et al. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11965-x
Bon, É., Delers, P., Dumont, F., Salman, B., Sapaly, D., Letourneur, F., Armand, A., & Lefebvre, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-56607-1
Development of a serum-based microRNA panel for Alzheimer's disease diagnosis
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Michele, M. D., Amisano, P., Bertuccini, L., Spadaro, F., Iosi, F., Carollo, M., Piscopo, P., Straface, E., Gambardella, L., Biglietto, M., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9518402/v1
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Tevlek, A. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017741
- Authors
- Manzini, V., Cappelletti, P., Orefice, N. S., Brentari, I., Rigby, M. J., Lo Giudice, M., Feligioni, M., Rivabene, R., Crestini, A., Manfredi, F., Talarico, G., Bruno, G., Corbo, M., Puglielli, L., Denti, M. A., & Piscopo, P.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Northwestern University (US)
- University of Trento (IT)
- Mayo Clinic (US)
- European Brain Research Institute (IT)
- Sapienza University of Rome (IT)
- University of Wisconsin–Madison (US)
- Corresponding author
- Denti, Michela A.
- Piscopo, Paola
- ORCID
- Venue
- Molecular Neurobiology
- Published
- 2024-08-14
- Volume
- 62
- Issue
- 2
- Pages
- 2573-2586
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC11772464
- OpenAlex
- W4401556606
- Cited by
- 16
- References
- 71
- Citations by year
- 2026: 10 · 2025: 6
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Iris (University of Trento) (submittedVersion, cc-by)
- Funders
- Fondazione Valorizzazione Ricerca Trentina; University of Trento (AB32 CUP I85H20000200005)
- Istituto Superiore di Sanità (BFC1)
- Università degli Studi di Trento
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal dementia, miR-92a-3p, miR-320a, miR-320b, circulating microRNAs, neuron-derived extracellular vesicles, plasma biomarkers, cerebrospinal fluid, Alzheimer's disease, liquid biopsy
- MeSH terms
- Extracellular Vesicles, Aged, Alzheimer Disease, Female, Humans, Male, Middle Aged, Neurons, Biomarkers, Up-Regulation, MicroRNAs, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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