Cited by 15Air Quality and Health ImpactsHealth, Environment, Cognitive AgingEnvironmental Justice and Health Disparities

Prenatal air pollution exposure is associated with inflammatory, cardiovascular, and metabolic biomarkers in mothers and newborns

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Ji, Nan, Eckel, Sandrah P., Foley, Helen, Yang, Tingyu, Lurmann, Fred, Grubbs, Brendan H., Habre, Rima, Bastain, Theresa M. +2 more·2024·Environmental Research

Abstract

Background Prenatal air pollution exposure has been associated with individual inflammatory, cardiovascular, and metabolic biomarkers in mothers and neonates. However, studies of air pollution and a comprehensive panel of biomarkers across maternal and cord blood samples remain limited. Few studies used data-driven methods to identify biomarker groupings that converge biomarkers from multiple biological pathways. This study aims to investigate the impacts of prenatal air pollution on groups of biomarkers in maternal and cord blood samples. Methods In the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) cohort, 87 biomarkers were quantified from 45 trimester 1 maternal blood and 55 cord blood samples. Pregnancy and trimester 1-averaged concentrations of particulate matter ≤2.5 μm and ≤10 μm in diameter (PM 2.5 and PM 10), nitrogen dioxide (NO 2), and ozone (O 3) were estimated, using inverse distance squared weighted spatial interpolation from regulatory air monitoring stations. Traffic-related NO x was assessed using California Line Source Dispersion Model: freeway/highway roads, non-freeway major roads, non-freeway minor roads, and their sum as total NOx. Elastic Net (EN) regression within the rexposome R package was used to group biomarkers and assess their associations with air pollution. Results In maternal samples, trimester 1-averaged PM 10 was associated with elevated inflammation biomarkers and lowered cardiovascular biomarkers. NO 2 exhibited positive associations with cardiovascular and inflammation markers. O 3 was inversely associated with inflammation, metabolic, and cardiovascular biomarkers. In cord blood, pregnancy-averaged PM 2.5 was associated with higher cardiovascular biomarkers and lower metabolic biomarkers. PM 10 was associated with lower inflammation and higher cardiovascular biomarkers. Total and major road NOx was associated with lower cardiovascular biomarkers. Conclusion Prenatal air pollution exposure was associated with changes in biomarkers related to inflammation, cardiovascular, metabolic, cancer, and neurological function in both mothers and neonates. This study shed light on mechanisms by which air pollution can influence biological function during pregnancy.

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Crossref · 10.1016/j.envres.2024.118797

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Authors
Ji, N., Eckel, S. P., Foley, H., Yang, T., Lurmann, F., Grubbs, B. H., Habre, R., Bastain, T. M., Farzan, S. F., & Breton, C. V.
Affiliations
University of Southern California (US)
Corresponding author
Breton, Carrie V.
Venue
Environmental Research
Publisher
Elsevier BV
Published
2024-07
Volume
252
Issue
Pt 1
Pages
118797
ISSN
0013-9351 (ISSN-L)
OpenAlex
W4393282992
Cited by
14
References
56
Citations by year
2026: 8 · 2025: 6
FWCI
2.47
Type
journal article
Language
en
Open access
Locations
  • Environmental Research (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
  • US Environmental Protection Agency (83615801\u20130)
  • National Institutes of Health (R01ES027409, UH3OD023287, P50MD015705, P50 ES026086, P30ES007048)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
Keywords
prenatal air pollution exposure, particulate matter, nitrogen dioxide, ozone, inflammatory markers, cardiovascular biomarkers, metabolic biomarkers, umbilical cord blood, maternal blood, pregnancy, neonates, MADRES cohort
MeSH terms
Adult, Air Pollutants, Air Pollution, California, Female, Fetal Blood, Humans, Infant, Newborn, Inflammation, Nitrogen Dioxide, Ozone, Pregnancy, Biomarkers, Maternal Exposure, Particulate Matter, Young Adult

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