Cited by 720Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureAntioxidant Activity and Oxidative Stress

Oxidative stress and air pollution exposure

Open access
Lodovici, Maura, Bigagli, Elisabetta·2011·Journal of Toxicology

Abstract

Air pollution is associated with increased cardiovascular and pulmonary morbidity and mortality. The mechanisms of air pollution-induced health effects involve oxidative stress and inflammation. As a matter of fact, particulate matter (PM), especially fine (PM(2.5), PM < 2.5 μm) and ultrafine (PM(0.1), PM < 0.1 μm) particles, ozone, nitrogen oxides, and transition metals, are potent oxidants or able to generate reactive oxygen species (ROS). Oxidative stress can trigger redox-sensitive pathways that lead to different biological processes such as inflammation and cell death. However, it does appear that the susceptibility of target organ to oxidative injury also depends upon its ability to upregulate protective scavenging systems. As vehicular traffic is known to importantly contribute to PM exposure, its intensity and quality must be strongly relevant determinants of the qualitative characteristics of PM spread in the atmosphere. Change in the composition of this PM is likely to modify its health impact.

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Research works printed but not linked: 2

  1. [85]Baulig A Garlatti M Bonvallot V Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells American Journal of Physiology 2003 285 3 L671 L679 12730081
  2. [99]Kosmider B Loader JE Murphy RC Mason RJ Apoptosis induced by ozone and oxysterols in human alveolar epithelial cells Free Radical Biology and Medicine 2010 48 11 1513 1524 20219673 PMC2965594

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Authors
Lodovici, M., & Bigagli, E.
Affiliations
University of Florence (IT)
Corresponding author
Lodovici, Maura
Venue
Journal of Toxicology
Publisher
Wiley
Published
2011
Volume
2011
Pages
1-9
ISSN
  • 1687-8191 (ISSN-L)
  • 1687-8205
OpenAlex
W2021290497
Cited by
720
References
108
Citations by year
2026: 42 · 2025: 70 · 2024: 69 · 2023: 67 · 2022: 74 · 2021: 73 · 2020: 84 · 2019: 58 · 2018: 45 · 2017: 34 · 2016: 31 · 2015: 24 · 2014: 24 · 2013: 15 · 2012: 8
FWCI
11.10
Type
journal article
Language
en
Open access
Locations
  • Journal of Toxicology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Università degli Studi di Firenze
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
oxidative stress, air pollution exposure, particulate matter, PM2.5, ultrafine particles, reactive oxygen species, inflammation, cardiovascular morbidity, pulmonary morbidity, ozone, nitrogen oxides, transition metals, cellular defense mechanisms, vehicle emissions, air pollution health effects

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