Oxidative stress and air pollution exposure
Open accessAbstract
Air pollution is associated with increased cardiovascular and pulmonary morbidity and mortality. The mechanisms of air pollution-induced health effects involve oxidative stress and inflammation. As a matter of fact, particulate matter (PM), especially fine (PM(2.5), PM < 2.5 μm) and ultrafine (PM(0.1), PM < 0.1 μm) particles, ozone, nitrogen oxides, and transition metals, are potent oxidants or able to generate reactive oxygen species (ROS). Oxidative stress can trigger redox-sensitive pathways that lead to different biological processes such as inflammation and cell death. However, it does appear that the susceptibility of target organ to oxidative injury also depends upon its ability to upregulate protective scavenging systems. As vehicular traffic is known to importantly contribute to PM exposure, its intensity and quality must be strongly relevant determinants of the qualitative characteristics of PM spread in the atmosphere. Change in the composition of this PM is likely to modify its health impact.
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Exposure to air pollution is mediated by oxidative stress in its damaging effects on many physiological functions.
“Additionally, there is a strong body of evidence that indicates exposure to air pollution is mediated by oxidative stress in its damaging effects on many physiological functions [35,37,38].”
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Li, Y., Takizawa, H., & Kawada, T. (2010) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152810793358787 · Cited by 34 · see citing works
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INFLAMMATORY CELL AVAILABILITY AFFECTS OZONE-INDUCED LUNG DAMAGE
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Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats
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Flagged first, then by citations
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- Authors
- Lodovici, M., & Bigagli, E.
- Affiliations
- University of Florence (IT)
- Corresponding author
- Lodovici, Maura
- Venue
- Journal of Toxicology
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-9
- ISSN
- 1687-8191 (ISSN-L)
- 1687-8205
- PMC
- PMC3155788
- OpenAlex
- W2021290497
- Cited by
- 720
- References
- 108
- Citations by year
- 2026: 42 · 2025: 70 · 2024: 69 · 2023: 67 · 2022: 74 · 2021: 73 · 2020: 84 · 2019: 58 · 2018: 45 · 2017: 34 · 2016: 31 · 2015: 24 · 2014: 24 · 2013: 15 · 2012: 8
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Toxicology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Università degli Studi di Firenze
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, air pollution exposure, particulate matter, PM2.5, ultrafine particles, reactive oxygen species, inflammation, cardiovascular morbidity, pulmonary morbidity, ozone, nitrogen oxides, transition metals, cellular defense mechanisms, vehicle emissions, air pollution health effects
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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