Cited by 244Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeuroscience and Neuropharmacology Research

Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)

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Bialer, Meir, Johannessen, Svein I., Levy, René H., Perucca, Emilio, Tomson, Torbjörn, White, H. Steve·2013·Epilepsy Research

Abstract

The Eleventh Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT XI, took place in Eilat, Israel from the 6th to 10th of May 2012. About 100 basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included "Indications overlapping with epilepsy" and "Securing the successful development of an investigational antiepileptic drug in the current environment". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 1994. Like the EILAT X report, the current manuscript focuses only on the preclinical and clinical pharmacology of AEDs that are currently in development. These include brivaracetam, 2-deoxy-glucose, ganaxolone, ICA-105665, imepitoin, NAX 801-2, perampanel and other AMPA receptor antagonists, tonabersat, valnoctamide and its homologue sec-propylbutylacetamide (SPD), VX-765 and YK3089. Since the previous Eilat conference, retigabine (ezogabine) has been marketed and four newer AEDs in development (NAX 810-2, SPD, tonabersat and VX-765) are included in this manuscript.

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Crossref · 10.1016/j.eplepsyres.2012.10.001

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  • Most antiepileptic drugs act by inhibiting voltage-gated sodium or calcium channels or potentiating GABA-mediated synaptic transmission, resulting in a symptomatic approach.

    “Although, there is an abundance of diverse antiepileptic drugs, most of them exert their actions by inhibition of the voltage-gated sodium or calcium channels or by potentiation of the GABA-mediated synaptic transmission [11], which results in a symptomatic approach in most cases; the goal of these drugs is to eliminate or at least reduce the number and/or severity of seizures.”

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  1. Reddy, D.S., Rogwski, M.A., 2012. Neurosteroids --Endogenous reg- ulators of seizure susceptibility and role in the treatment of epilepsy (Chapter 77), Jasper's Basic Mechanisms of the Epilep- sies, Fourth Edition. In: Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W., Delgado-Escueta, A.V. (Eds.), Contemporary Neu- rology Series 80. Oxford University Press, pp. 984-1002.

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Authors
Bialer, M., Johannessen, S. I., Levy, R. H., Perucca, E., Tomson, T., & White, H. S.
Affiliations
  • Hebrew University of Jerusalem (IL)
  • Oslo University Hospital (NO)
  • University of Washington (US)
  • University of Pavia (IT)
  • Karolinska Institutet (SE)
  • University of Utah (US)
Corresponding author
Bialer, Meir
Venue
Epilepsy Research
Publisher
Elsevier BV
Published
2013-01
Volume
103
Issue
1
Pages
2-30
ISSN
0920-1211 (ISSN-L)
OpenAlex
W2203865877
Cited by
243
References
98
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 13 · 2022: 20 · 2021: 17 · 2020: 32 · 2019: 12 · 2018: 10 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 24 · 2013: 20
FWCI
2.88
Type
journal article
Language
en
Open access
Locations
  • Epilepsy Research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institutes of Health
  • UCB Pharma
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
antiepileptic drugs, drug development, preclinical pharmacology, clinical pharmacology, brivaracetam, 2-deoxyglucose, ganaxolone, perampanel, AMPA receptor antagonists, tonabersat, retigabine, ezogabine, VX-765, epilepsy
MeSH terms
Animals, Anticonvulsants, Clinical Trials as Topic, Congresses as Topic, Epilepsy, Humans, Israel, Drugs, Investigational, Research Report

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