Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy
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Silencing activity of miR-146a-5p decreases hyperexcitability-underlying seizures in a model of epileptogenesis.
“Its silencing activity has recently been shown to decrease hyperexcitability-underlying seizures in a model of epileptogenesis, where gliosis and inflammatory cytokines are major pathogenic factors [34].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [34]
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A basic introduction to fixed-effect and random-effects models for meta-analysis
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2010) · Research Synthesis Methods · doi:10.1002/jrsm.12 · Cited by 6,793 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · cited 2× · see citing works
“S1A,C), in accordance with previous evidence reporting that these proteins are the primary targets of this miRNA (Taganov et al., 2006; O'Neill, 2008; Boldin et al., 2011; Iyer et al., 2012; Zeng et al., 2013; van Scheppingen et al., 2016); a negative correlation was found between miR-146a and…”
BackgroundResultSilencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response
Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330 · see citing works
Self-citationProgress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)
Bialer, M., Johannessen, S. I., Levy, R. H., Perucca, E., Tomson, T., & White, H. S. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.10.001 · Cited by 243 · see citing works
Self-citationLiu, G., Gu, B., He, X.-P., Joshi, R. B., Wackerle, H. D., Rodriguiz, R. M., Wetsel, W. C., & McNamara, J. O. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.027 · Cited by 210 · see citing works
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Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312 · see citing works
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Buffolo, F., Petrosino, V., Albini, M., Moschetta, M., Carlini, F., Floss, T., Kerlero de Rosbo, N., Cesca, F., Rocchi, A., Uccelli, A., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03465-6 · Cited by 60 · see citing works
- Authors
- Iori, V., Iyer, A. M., Ravizza, T., Beltrame, L., Paracchini, L., Marchini, S., Cerovic, M., Hill, C., Ferrari, M., Zucchetti, M., Molteni, M., Rossetti, C., Brambilla, R., Steve White, H., D'Incalci, M., Aronica, E., & Vezzani, A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 99
- Pages
- 12-23
- ISSN
- 0969-9961
- Cited by
- 177
- References
- 6
- Language
- en
- Funders
- Fondazione Umberto Veronesi
- Seventh Framework Programme (602102, 602391)
- Hersenstichting (NF-13-1VI)
- Fondazione Antonio Carlo Monzino
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