Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury

Li, Yongjin; Shi, Wei; Li, Yindong; Zhou, Yong; Hu, Xuefeng; Song, Chunmei; Ma, Hongbo; Wang, Changwen; Li, Yong

doi:10.1016/j.etap.2007.12.008

Cited by 109Heavy Metal Exposure and ToxicityMercury impact and mitigation studiesNeurological Disorders and Treatments

Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury

Li, Yongjin, Shi, Wei, Li, Yindong, Zhou, Yong, Hu, Xuefeng, Song, Chunmei, Ma, Hongbo, Wang, Changwen +1 more·2008·Environmental Toxicology and Pharmacology

DOI 10.1016/j.etap.2007.12.008

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Abstract

Chlorogenic acid (CGA) widely exists in edible and medicinal plants. We aimed to evaluate the effect of CGA on the protection from apoptosis by methylmercury (MeHg) in PC12 cells. Cell viability was evaluated by MTT assay. Apoptosis was assayed by flow cytometry detection. Caspase-3 activity was measured by confocal microscopy. Intracellular GSH levels were determined by bicinchoninic acid protein assay. Intracellular reactive oxygen species (ROS) was assessed by means of chloromethyl-dihydrodichlorofluorescein diacetate. Glutathione peroxidase (GPx) activity was determined by UV. In order to elucidate the action of CGA, the protective effects of CGA were compared to Vit.E. CGA was effective at protecting PC12 cells against MeHg-induced damage in dose-dependent manner. CGA not only suppressed the generation of ROS, the decrease of activity in GPx and the decrease of GSH, but also attenuated caspase-3 activation in PC12 cells by MeHg. CGA eventually protected PC12 cells against MeHg-induced apoptosis. The results highlighted that CGA may exert neuroprotective effects through its antioxidant actions.

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From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [146]

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Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice
Yuan, Y., Gong, X., Zhang, L., Jiang, R., Yang, J., Wang, B., & Wan, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.01.017 · Cited by 56 · see citing works
Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors
Alqarni, I., Bassiouni, Y. A., Badr, A. M., & Ali, R. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.018 · Cited by 52 · see citing works
Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d -galactose-induced aging mice
Turgut, N. H., Mert, D. G., Kara, H., Eğilmez, H. R., Arslanbaş, E., Tepe, B., Güngör, H., Yilmaz, N., & Tuncel, N. B. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1101476 · Cited by 49 · see citing works
“These results suggest that chlorogenic acid may apply neuroprotective effects through its antioxidant actions (Li et al. 2008).”
Background
Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro
Yang, L., Wang, N., & Zheng, G. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2720-1 · Cited by 48 · see citing works
Effect of chlorogenic acid on alleviating inflammation and apoptosis of IPEC-J2 cells induced by deoxyniyalenol
Xu, X., Chang, J., Wang, P., Yin, Q., Liu, C., Li, M., Song, A., Zhu, Q., & Lu, F. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111376 · Cited by 48 · see citing works
Smilax aristolochiifolia Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of α‐Amylase and α‐Glucosidase Enzymes
Pérez-Nájera, V. C., Gutierrez-Uribe, J. A., Antunes‐Ricardo, M., Hidalgo‐Figueroa, S., Del‐Toro‐Sánchez, C. L., Salazar‐Olivo, L. A., & Lugo‐Cervantes, E. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/6247306 · Cited by 47 · see citing works
Chlorogenic Acid Attenuates Oxidative Stress-Induced Intestinal Mucosa Disruption in Weaned Pigs
Chen, J., Chen, D., Yu, B., Luo, Y., Zheng, P., Mao, X., Yu, J., Luo, J., Huang, Z., Yan, H., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.806253 · Cited by 46 · see citing works
“Previous studies indicated that CGA has multiple benefits for mammalian animals, including antioxidant, anti-inflammatory, and antibacterial activities (8, 9).”
Background
Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model
Hao, M., Pan, N., ZHANG, Q.-H., & WANG, X.-H. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2367 · Cited by 46 · see citing works
“The findings observed in the present study are consistent with previous findings (22).”
Novel Nutraceutical Compounds in Alzheimer Prevention
Maccioni, R. B., Calfío, C., González, A., & Lüttges, V. (2022) · Biomolecules · doi:10.3390/biom12020249 · Cited by 45 · see citing works
“In this study, chlorogenic acid prevents the generation of reactive-oxygen species (ROS), suppressing the decreasing action of glutathione peroxidase (GPx) and Glutathione (GSH) and attenuating apoptosis by the activation of caspase-3 [55] (Figure 3).”
Background
Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia
Hermawati, E., Arfian, N., Mustofa, M., & Partadiredja, G. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14556 · Cited by 44 · see citing works
6-OHDA mediated neurotoxicity in SH-SY5Y cellular model of Parkinson disease suppressed by pretreatment with hesperidin through activating L-type calcium channels
Elyasi, L., Jahanshahi, M., Jameie, S. B., Abadi, H. G. H., Nikmahzar, E., Khalili, M., Jameie, M., & Jameie, M. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0270 · Cited by 36 · see citing works
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway
Wang, Q., Liu, T., Koci, M. D., Wang, Y., Fu, Y., Ma, M., Ma, Q., & Zhao, L. (2023) · Antioxidants · doi:10.3390/antiox12122027 · Cited by 35 · see citing works
Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function
Fukagawa, S., Haramizu, S., Sasaoka, S., Yasuda, Y., Tsujimura, H., & Murase, T. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1345614 · Cited by 35 · see citing works
Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic Disease-induced Rats
Arshad, N. ‘., Teoh, S. L., & Yahaya, M. F. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200117105133 · Cited by 30 · see citing works
Neuroprotective Effect of Caffeoylquinic Acids from Artemisia princeps Pampanini against Oxidative Stress‐Induced Toxicity in PC‐12 Cells
Lee, S. G., Lee, H., Nam, T. G., Eom, S. H., Heo, H. J., Lee, C. Y., & Kim, D. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.02010.x · Cited by 29 · see citing works
Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals
Bjørklund, G., Antonyak, H., Polishchuk, A. I., Semenova, Y. M., Lesiv, M., Lysiuk, R., & Peana, M. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03366-3 · Cited by 29 · see citing works
“However, they can also be mediated by their ability to influence the expression of regulatory and functional protein molecules, including the expression of extracellular signal-regulated kinases (ERKs), members of the Rho family of GTPases (such as RhoA, Rac1, and Cdc42), including caspases, antiapoptotic Bcl-2 protei…”
Background
Preventive effects of crocin on neuronal damages induced by D-galactose through AGEs and oxidative stress in human neuroblastoma cells (SH-SY5Y)
Heidari, S., Mehri, S., Shariaty, V., & Hosseinzadeh, H. (2018) · Journal of pharmacopuncture · doi:10.3831/kpi.2018.21.003 · Cited by 26 · see citing works
Changes in the Physicochemical Properties and Sensory Characteristics of Burdock (Arctium lappa) During Repeated Steaming and Drying Procedures
Lee, G., Son, Y., Jeon, Y.-H., Kang, H., & Hwang, I. (2015) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2015.47.3.336 · Cited by 25 · see citing works
“혈압강하와 관련이 있는 것으로, 리그난의 일종인 아크티게닌 (arctigenin)과 아크티인(arctiin)은 항종양에 효과적인 것으로 발표 되었다(6-10).”
Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice
Sun, G.-G., Shih, J.-H., Chiou, S., Hong, C., Lu, S.-W., & Pao, L. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.07.025 · Cited by 25 · see citing works
Protective effect of hopeahainol A, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced injury in PC12 cells
Shi, D. H., Wu, J. H., Ge, H. M., & Tan, R. X. (2009) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2009.01.009 · Cited by 25 · see citing works
Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways
Jiang, H., Li, J., Zhou, T., Wang, C., Zhang, H., & Wang, H. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1684 · Cited by 25 · see citing works
“Consequently, PC12 cells are considered a useful model for studying the mechanism of apoptosis induced by methyl mercury, paraquat and manganese (21-23).”
Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry
Hu, S., Zhao, R., Chi, X., Chen, T., Li, Y., Xu, Y., Zhu, B., & Hu, J. (2024) · Food & Function · doi:10.1039/d4fo00059e · Cited by 24 · see citing works
Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of streptozotocin-induced diabetic rats
Stefanello, N., Schmatz, R., Pereira, L. B., Cardoso, A. M., Passamonti, S., Spanevello, R. M., Thomé, G. R., de Oliveira, G. M. T., Kist, L. W., Bogo, M. R., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.015 · Cited by 24 · see citing works
“[20] Li Y, Shi W, Zhou Y, Hu X, Song C, Ma H, et al.”
Background
The protective effect of fasudil against acrylamide-induced cytotoxicity in PC12 cells
Kianfar, M., Nezami, A., Mehri, S., Hosseinzadeh, H., Hayes, A. W., & Karimi, G. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1536140 · Cited by 24 · see citing works
Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications
Xu, J., Zhao, X., Yang, S., Tang, M., Zhao, R., & Hu, S. (2025) · Food & Function · doi:10.1039/d5fo00853k · Cited by 23 · see citing works
Inhibition of acid-sensing ion channels by chlorogenic acid in rat dorsal root ganglion neurons
Qu, Z., Liu, T., Qiu, C., Li, J., & Hu, W. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.03.027 · Cited by 23 · see citing works
Roasting has a distinct effect on the antimutagenic activity of coffee varieties
Priftis, A., Mitsiou, D., Halabalaki, M., Ntasi, G., Stagos, D., Skaltsounis, A., & Kouretas, D. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.03.003 · Cited by 23 · see citing works
Biological activity of Hyptis Jacq. (Lamiaceae) is determined by the environment
dos Santos, K. P., Sedano-Partida, M. D., Sala‐Carvalho, W. R., Loureiro, B. O. S. J., da Silva-Luz, C. L., & Furlan, C. M. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.12.065 · Cited by 23 · see citing works
Effects of chlorogenic acid on voltage-gated potassium channels of trigeminal ganglion neurons in an inflammatory environment
Liu, F., Lu, X.-W., Zhang, Y.-J., Kou, L., Song, N., Wu, M.-K., Wang, M., Wang, H., & Shen, J. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.09.005 · Cited by 22 · see citing works
Structure–activity relationships of acetylated flavone glycosides from Galeopsis ladanum L. (Lamiaceae)
Uriarte-Pueyo, I., & Calvo, M. I. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.10.060 · Cited by 20 · see citing works
Pharmacognostic Specification, Chlorogenic Acid Content, and In vitro Antioxidant Activities of Lonicera japonica Flowering Bud.
Chaowuttikul, C., Palanuvej, C., & Ruangrungsi, N. (2017) · Europe PMC (PubMed Central) · doi:10.4103/pr.pr_117_16 · Cited by 20 · see citing works
“[15] Chlorogenic acid has been shown its biological and physiological activities such as antihyperalgesic,[16] radioprotective,[17] anti‐inflammatory,[18] antiulcerogenic,[19] antihepatotoxic,[20] neuroprotective effects,[21] and antioxidant activity of chlorogenic acid‐rich extract from Etlingera elatior leaves.”
Background
Modulation of the effects of methylmercury on rat neurodevelopment by co-exposure with Labrador Tea (Rhododendron tomentosum ssp. subarcticum)
Black, P. L., Niu, L., Sachdeva, M., Lean, D. R. S., Poon, R. W. M., Bowers, W. J., Chan, H. M., Arnason, J. T., & Pelletier, G. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.06.035 · Cited by 20 · see citing works
“, 2008; Cho and Lee, 2004) and interestingly, similar findings have been reported following co-exposure with MeHg (Lucena et al., 2007; Yongjin et al., 2008; Farina et al., 2005).”
Result
Efficient and selective extraction of chlorogenic acid in juice samples using magnetic molecularly imprinted polymers
Cheng, Y., Liu, H., Li, J., Kuang, L., & Xu, G. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.108110 · Cited by 19 · see citing works
Neuroprotective Effect of Chlorogenic Acids against Alzheimer’s Disease
Anggreani, E., & Lee, C. Y. (2017) · International Journal of Food Science Nutrition and Dietetics · doi:10.19070/2326-3350-1700059 · Cited by 19 · see citing works
“Reduction of apoptotic cells, caspase-3 activity, and suppression of ROS formation were observed [26].”
BackgroundInfluential
Identification of a Hydroxygallic Acid Derivative, Zingibroside R1 and a Sterol Lipid as Potential Active Ingredients of Cuscuta chinensis Extract That Has Neuroprotective and Antioxidant Effects in Aged Caenorhabditis elegans
Sayed, S. M. A., Alseekh, S., Siems, K., Fernie, A. R., Luyten, W. H. M. L., Schmitz‐Linneweber, C., & Saul, N. (2022) · Nutrients · doi:10.3390/nu14194199 · Cited by 19 · see citing works
Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels
Osmakov, D. I., Khasanov, T. A., Andreev, Y. A., Lyukmanova, E. N., & Kozlov, S. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00991 · Cited by 18 · see citing works
Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells.
Jiang, H., Lv, P., Li, J., Wang, H., Zhou, T., Liu, Y., & Wei, L. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.28.001 · Cited by 17 · see citing works
“After loading, cells were washed twice with normal medium and DCF fluorescence was measured using the Wallac Victor Multilabel Counter (Perkin Elmer, Vernon Hills, USA) with excitation and emission wavelengths of 485 and 530 nm, respectively [32-33] .”
Method
Ethanolic extract from bulbs of Cipura paludosa reduced long-lasting learning and memory deficits induced by prenatal methylmercury exposure in rats
Lucena, G. M. R. S., Prediger, R. D., Silva, M. V., dos Santos, S. N., Silva, J. F. B., Santos, A. R. S., Azevedo, M. S. D., & Ferreira, V. M. M. (2012) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2012.08.003 · Cited by 17 · see citing works
Increased putrescine levels due to ODC1 overexpression prevents mitochondrial dysfunction-related apoptosis induced by methylmercury
Sato, M., Toyama, T., Kim, M., Lee, J.-Y., Hoshi, T., Miura, N., Naganuma, A., & Hwang, G. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118031 · Cited by 17 · see citing works
Potential Protective Effects of Spirulina (Spirulina platensis) against In Vitro Toxicity Induced by Heavy Metals (Cadmium, Mercury, and Lead) on SH-SY5Y Neuroblastoma Cells
Mallamaci, R., Storelli, M. M., Barbarossa, A., Messina, G., Valenzano, A. A., & Meleleo, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317076 · Cited by 16 · see citing works
“As shown by the treatment of neuronal cells with both Spirulina and a heavy metal solution, the proliferative effect of our Spirulina platensis on SH-SY5Y cells may be attributed to its neuroprotective action against heavy-metals-induced cell damage [43].”
Background
Plant components can reduce methylmercury toxication: A mini-review
Chang, J., Zhou, Y., Wang, Q., Aschner, M., & Lu, R. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.01.012 · Cited by 16 · see citing works
A comprehensive perspective on the disposition, metabolism, and pharmacokinetics of representative multi-components of Dengzhan Shengmai in rats with chronic cerebral hypoperfusion after oral administration
Ma, C., Sheng, N., Li, Y., Zheng, H., Wang, Z., & Zhang, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116212 · Cited by 15 · see citing works
Role of fruits in aging and age-related disorders
Arif, M. U., Khan, M. K. I., Riaz, S., Nazir, A., Maan, A. A., Amin, U., Saeed, F., & Afzaal, M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111763 · Cited by 15 · see citing works
Decoding natural products for neuroprotection: Pathway networks and structural insights for drug development
Ghosh, S., Debnath, I., Bhunia, S., Nandi, S., Ashique, S., Nayak, A., Mallick, S., & Basak, S. (2025) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2025.09.005 · Cited by 15 · see citing works
“Cytochrome c release activates Caspase-3, a key executioner of apoptosis.”
Influential
Electrochemical behaviour of new dimeric esters and amides derived from caffeic acid in dimethylsulfoxide
Sánchez, A., Martínez-Mora, O., Martínez-Benavidez, E., Hernández, J., Domínguez, Z., & Salas, M. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00823e · Cited by 13 · see citing works
Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival
Mikami, Y., Kakizawa, S., & Yamazawa, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101652 · Cited by 12 · see citing works
“Given its neuroprotective effect in PC12 cells, CGA is one of the candidate components in coffee that may protect neurons from degeneration [59,63,64].”
Background
Protective effect of aqueous and ethanolic extracts of Lippia citriodora Kunth. on acrylamide-induced neurotoxicity.
Tandisehpanah, Z., Foroutanfar, A., Aziminia, A., Rahbardar, M. G., Razavi, B. M., & Hosseinzadeh, H. (2022) · PubMed Central · doi:10.22038/ajp.2021.19173 · Cited by 12 · see citing works
“The 2,7 dichloro-dihydro-fluorescein diacetate (DCFH-DA) technique was used to evaluate the intracellular ROS levels (Li et al., 2008).”
Method
Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells
Domith, I., Duarte-Silva, A. T., Garcia, C. G., Calaza, K. D. C., Paes‐de‐Carvalho, R., & Cossenza, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.023 · Cited by 12 · see citing works
Effect of trans-sodium crocetinate on contrast-induced cytotoxicity in HEK-293 cells.
Rajabian, F., Mehri, S., Razavi, B. M., Rad, A. K., Rahbardar, M. G., & Hosseinzadeh, H. (2023) · PubMed Central · doi:10.22038/ijbms.2022.64671.14234 · Cited by 11 · see citing works
Effect of burdock extract on physical performance and physiological fatigue in mice
Chen, W.-C., Hsu, Y.-J., Lee, M., Hua Shuai, L. I., Ho, C.-S., Huang, C., & Chen, F. (2017) · Journal of Veterinary Medical Science · doi:10.1292/jvms.17-0345 · Cited by 10 · see citing works
“Many studies have confirmed that BD has antitumor [3], antioxidative [29], anti-inflammatory [24], antibacterial [43], prebiotic [26], and anti-HIV properties [41], inhibits NO production [30], and prevents diabetic complications [42].”
Background
A randomized double blinded placebo controlled clinical trial for the evaluation of green coffee extract on immune health in healthy adults
Narayanaperumal, J., D'souza, A., Miriyala, A., Sharma, B., & Gopal, G. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.01.007 · Cited by 9 · see citing works
Evaluation of the immunosensitizing potential of chlorogenic acid using a popliteal lymph node assay in BALB/c mice
Liu, Z., Liu, Z., Shi, Y., & Zhou, G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.024 · Cited by 9 · see citing works
Preparation and crystallographic studies of a new mercuric salicylaldimine complex for fabrication of microscaled and nanoscaled mercuric sulfide as antimicrobial agents against human pathogenic yeasts and filamentous fungi
Ibrahim, A. B. M., Mahmoud, G. A., Meurer, F., & Bodensteiner, M. (2020) · Applied Organometallic Chemistry · doi:10.1002/aoc.6134 · Cited by 8 · see citing works
Osthole attenuated cytotoxicity induced by 6-OHDA in SH-SY5Y cells through inhibition of JAK/STAT and MAPK pathways.
Barangi, S., Hosseinzadeh, P., Karimi, G., Najaran, Z. T., & Mehri, S. (2023) · PubMed Central · doi:10.22038/ijbms.2023.68292.14905 · Cited by 7 · see citing works
Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders
Lal, U. R., & Lal, S. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92043 · Cited by 7 · see citing works
“It prevents the generation of reactive-oxygen species (ROS), suppressing the decreasing action of glutathione peroxidase (GPx) and GSH and attenuating apoptosis by the activation of caspase-3 [33] and also inhibits the activity of acetylcholine esterase and MDA in the hippocampus as well as in the frontal cortex in mi…”
Background
Yi Qi Qing Re Gao formula ameliorates puromycin aminonucleoside-induced nephrosis by suppressing inflammation and apoptosis
Wen, Y., Zhan, Y., Liu, H., Zhao, T., Yang, L., Zhang, H., Dong, X., & Li, P. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0673-9 · Cited by 6 · see citing works
“Chlorogenic acid, the main component of Lonicera japonica, may protect cells against apoptosis by attenuating caspase-3 activation [39].”
Background
Cirsium japonicum Extracts Show Antioxidant Activity and PC12 Cell Protection against Oxidative Stress
Jang, M., & Kim, G. (2016) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2016.48.2.172 · Cited by 6 · see citing works
“(32)는 chlorogenic acid가 methylmercury로 산화적 독성을 유도한 PC12 신경세포에 대하여 세포자살 저해 및 신경세포 보호효과를 나타낸다고 보고하였다.”
Effects of β-HgS on cell viability and intracellular oxidative stress in PC-12 cells
Geng, L., Xia, Z., Lu, Y., Li, C., Zhang, M., Du, Y., Wei, L., & Bi, H. (2020) · Metallomics · doi:10.1039/d0mt00088d · Cited by 4 · see citing works
Effect of Moringa oleifera leaf extract on the Histopathological Features of Testicular SeminiferousTubules of Mice (Mus musculus) Exposed to Methylmercury
Proboningrat, A., Plumeriastuti, H., Utama, S., Sudjarwo, S. A., Legowo, D., Luqman, E. M., & Widjiati, M. (2022) · Ecology Environment and Conservation · doi:10.53550/eec.2022.v28i01.031 · Cited by 3 · see citing works
Trans-sodium crocetinate suppresses apoptotic and oxidative response following myoglobin-induced cytotoxicity in HEK-293 cells.
Aminifard, T., Mehri, S., Rahbardar, M. G., Rajabian, F., Rad, A. K., & Hosseinzadeh, H. (2024) · PubMed Central · doi:10.22038/ijbms.2024.75306.16322 · Cited by 3 · see citing works
Honey: A Sweet Way to Health
Ahluwalia, M., Ahluwalia, P. K., Dhandapani, K. M., & Vaibhav, K. (2020) · Springer eBooks · doi:10.1007/978-981-15-6799-5_4 · Cited by 3 · see citing works
Determination of Chlorogenic Acid in Solid-lipid Nanoparticles: Validation by UV-spectroscopy
Rana, T., Goyal, A., & Behl, T. (2024) · Current Pharmaceutical Analysis · doi:10.2174/0115734129303063240711073707 · Cited by 2 · see citing works
Valerian and Yarrow: Two medicinal Plants as Crop Protectant Against Late Frost
Institut Technique de l’Agriculture Biologique (ITAB), 1. R. D. B., Stefanini, M., Merrien, L., Institut Technique de l’Agriculture Biologique (ITAB), 1. R. D. B., Marchand, P. A., & Institut Technique de l’Agriculture Biologique (ITAB), 1. R. D. B. (2018) · International Journal of Economic Plants · doi:10.23910/ijep/2018.5.4.0274 · Cited by 2 · see citing works
Recent Advances in the Discovery of Bioactive Components from Natural Honey
Rather, M. A., Bashir, S. M., Mumtaz, P. T., Amin, I., & Ali, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-6799-5_9 · Cited by 2 · see citing works
Fasudil Attenuated 6-OHDA Cytotoxicity in PC12 Cells through Inhibition of JAK/STAT and Apoptosis Pathways
Barangi, S., Hosseini, S. M., Karimi, G., & Mehri, S. (2022) · Pharmaceutical Sciences · doi:10.34172/ps.2022.33 · Cited by 1 · see citing works
“After that, cells were washed with PBS and the fluorescence intensity of DCF was read at 485 and 538 nm for the excitation and emission wavelength, respectively by a microplate-reader.(19)”
Method
Nutraceuticals and the Microbiota–Gut–Brain Axis: A Pathway for Preventing Cognitive Decline
Castillo-Moral, Á., Toda-Ferran, C., Bulló, M., Teichenné, J., & Escoté, X. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag017 · Cited by 1 · see citing works
Neuroprotective Effects of Honey: A Mechanistic View
Dar, N. J. (2020) · Springer eBooks · doi:10.1007/978-981-15-7305-7_3 · Cited by 1 · see citing works
Chlorogenic acid co‐administration alleviates cisplatin‐induced peripheral neuropathy in rats
Ünel, Ç. Ç., Eroglu, E., Özatik, O., & Erol, K. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12970 · Cited by 1 · see citing works
Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an In Vitro Model Based on Differentiated PC12 Cells
Aliyan, S. M. S., Roohbakhsh, A., Fakhrabad, M. J., Salmasi, Z., Moshiri, M., Shahbazi, N., & Etemad, L. (2024) · Alternatives to Laboratory Animals · doi:10.1177/02611929241237409 · Cited by 1 · see citing works
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Authors: Li, Y., Shi, W., Li, Y., Zhou, Y., Hu, X., Song, C., Ma, H., Wang, C., & Li, Y.
Affiliations: Peking University (CN)
Jilin Medical University (CN)
ORCID: Li, Yongjin
Shi, Wei
Li, Yindong
Zhou, Yong
Hu, Xuefeng
Wang, Changwen
Li, Yong
Venue: Environmental Toxicology and Pharmacology
Publisher: Elsevier BV
Published: 2008-07
Volume: 26
Issue: 1
Pages: 13-21
ISSN: 1382-6689 (ISSN-L)
DOI: 10.1016/j.etap.2007.12.008
OpenAlex: W2081236308
Cited by: 109
References: 47
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 13 · 2020: 15 · 2019: 4 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 1
FWCI: 1.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Environmental Toxicology and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords: chlorogenic acid, methylmercury, neuroprotection, apoptosis, PC12 cells, caspase-3, reactive oxygen species, glutathione, glutathione peroxidase, antioxidant activity, mercury neurotoxicity

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Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury

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