Novel Nutraceutical Compounds in Alzheimer Prevention
Open accessAbstract
Alzheimer’s disease (AD) incidence is increasing worldwide at an alarming rate. Considering this increase, prevention efforts, stemming from scientific research, health education, and public policies, are critical. Clinical studies evidenced that healthy lifestyles along with natural multitarget and disease-modifying agents have a preventative impact on AD or mitigate symptoms in diagnosed patients. The pathological alterations of AD start 30 years before symptoms, and it is essential to develop the capacity to detect those changes. In this regard, molecular biomarkers that detect early pathological manifestations are helpful. Based on markers data, early preventive interventions could reduce more than 40% of AD cases. Protective actions include exercise, shown to induce neurogenesis, cognitive stimulation, intellectual-social activity, and nutrition among others. Mediterranean diet, preprobiotics, and nutraceuticals containing bioactive molecules with antioxidant and anti-inflammatory properties are relevant. Antiprotein aggregation molecules whose mechanisms were described are important. Anti-inflammatory agents with anti-aggregation properties that help to control cognitive impairment, include quercetin, biocurcumin, rosemarinic acid, and Andean shilajit. Anthocyanidins, e.g., delphinidin, malvidin, and natural flavonoids, are also included. Quercetin and hydroxy-tyrosol are antiaging molecules and could have anti-AD properties. We emphasize the relevance of nutraceuticals as a main actor in the prevention and/or control of dementia and particularly AD.
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Natural formulas with anti-inflammatory activity have been developed to treat AD.
“In addition, natural formulas with anti-inflammatory activity have been developed to treat AD.543”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [543]
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2 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · cited 2× · see citing works
“Antitau, antiamyloid, and anti-inflammatory molecules continue to b in focus where presymptomatic interventions are necessary [88].”
BackgroundRetractedSayed, N. S. E., Kandil, E. A., & Ghoneum, M. H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5525306 · Cited by 28 · see citing works
RetractedDietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works
Health effects of quercetin: From antioxidant to nutraceutical
Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works
The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111 · see citing works
Phenolic Compounds in Honey and Their Associated Health Benefits: A Review
Cianciosi, D., Forbes-Hernández, T. Y., Afrin, S., Gasparrini, M., Reboredo‐Rodríguez, P., Manna, P. P., Zhang, J., Bravo‐Lamas, L., Martínez‐Flórez, S., Agudo-Toyos, P., et al. (2018) · Molecules · doi:10.3390/molecules23092322 · Cited by 774 · see citing works
Sun, M., Wu, W. H., Chen, L., Yang, W., Huang, X., Ma, C., Chen, F., Xiao, Y., Zhao, Y., Ma, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05901-2 · Cited by 667 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
Costa, L. G., Garrick, J. M., Roqué, P. J., & Pellacani, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2986796 · Cited by 550 · see citing works
2009 Alzheimer's disease facts and figures
Alzheimer's Association (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.03.001 · Cited by 546 · see citing works
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 541 · see citing works
Probiotic Dairy Products as Functional Foods
Granato, D., Branco, G. F., da Cruz, A. G., Faria, J. D. A. F., & Shah, N. P. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2010.00120.x · Cited by 500 · see citing works
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works
Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis
Malaguarnera, M., Vacante, M., Antic, T., Giordano, M., Chisari, G., Acquaviva, R., Mastrojeni, S., Malaguarnera, G., Mistretta, A., Volti, G. L., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1887-4 · Cited by 456 · see citing works
Kwon, S.-H., Lee, H.-K., Kim, J.-A., Hong, S.-I., Kim, H.-C., Jo, T.-H., Park, Y.-I., Lee, C.-K., Kim, Y.-B., Lee, S.-Y., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.001 · Cited by 437 · see citing works
Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 434 · see citing works
Microbes and mental health: A review
Rieder, R., Wisniewski, P. J., Alderman, B. L., & Campbell, S. C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.016 · Cited by 429 · see citing works
Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases
Chi, H., Chang, H.-Y., & Sang, T.-K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103082 · Cited by 412 · see citing works
Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
Luo, Y., Smith, J. V., Paramasivam, V., Burdick, A. J., Curry, K. J., Buford, J. P., Khan, I. A., Netzer, W. J., Xu, H., & Butko, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182425199 · Cited by 399 · see citing works
Boswellia serrata, a potential antiinflammatory agent: an overview.
Siddiqui, M. (2011) · PubMed Central · doi:10.4103/0250-474x.93507 · Cited by 389 · see citing works
Microbiological, technological and therapeutic properties of kefir: a natural probiotic beverage
Leite, A. M. D. O., Miguel, M. A. L., Peixoto, R. S., Rosado, A. S., Silva, J. T., & Paschoalin, V. M. F. (2013) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822013000200001 · Cited by 376 · see citing works
Taormina, P. J., Niemira, B. A., & Beuchat, L. R. (2001) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00505-0 · Cited by 347 · see citing works
Effect of probiotics on central nervous system functions in animals and humans: a systematic review
Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334 · see citing works
Álvarez-Suárez, J. M., Giampieri, F., & Battino, M. A. (2013) · Current Medicinal Chemistry · doi:10.2174/092986713804999358 · Cited by 333 · see citing works
Targeting senescent cells in translational medicine
Pàez‐Ribes, M., González‐Gualda, E., Doherty, G. J., & Muñoz‐Espín, D. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810234 · Cited by 289 · see citing works
The Role of Neuroimmunomodulation in Alzheimer's Disease
Maccioni, R. B., Rojo, L. E., Fernández, J. A., & Kuljiš, R. O. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03972.x · Cited by 261 · see citing works
Self-citationCellular senescence and Alzheimer disease: the egg and the chicken scenario
Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works
Vauzour, D., Vafeiadou, K., Rice-Evans, C. A., Williams, R. J., & Spencer, J. P. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04841.x · Cited by 254 · see citing works
Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works
Bastianetto, S., Zheng, W., & Quirion, R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742268.x · Cited by 222 · see citing works
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221 · see citing works
Cheng, C.-Y., Su, S.-Y., Tang, N.-Y., Ho, T., Chiang, S., & Hsieh, C. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.090 · Cited by 217 · see citing works
Miller, K., Feucht, W., & Schmid, M. (2019) · Nutrients · doi:10.3390/nu11071510 · Cited by 207 · see citing works
Bowtell, J. L., Bakkar, Z. A., Conway, M. E., Adlam, A., & Fulford, J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0550 · Cited by 202 · see citing works
Beneficial roles of honey polyphenols against some human degenerative diseases: A review
Hossen, M. S., Ali, M. Y., Jahurul, M. H. A., Abdel‐Daim, M. M., Gan, S. H., & Khalil, M. I. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.07.002 · Cited by 185 · see citing works
Promoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 181 · see citing works
Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease
Bulck, M. V., Sierra‐Magro, A., Alarcón-Gil, J., Pérez‐Castillo, A., & Morales-Garcia, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030719 · Cited by 179 · see citing works
Ferulic acid destabilizes preformed β-amyloid fibrils in vitro
Ono, K., Hirohata, M., & Yamada, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.148 · Cited by 171 · see citing works
Enhanced neural activation with blueberry supplementation in mild cognitive impairment
Boespflug, E. L., Eliassen, J. C., Dudley, J. A., Shidler, M. D., Kalt, W., Summer, S. S., Stein, A. L., Stover, A. N., & Krikorian, R. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1287833 · Cited by 171 · see citing works
Prebiotics: Definition and protective mechanisms
Valcheva, R. S., & Dieleman, L. A. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.008 · Cited by 169 · see citing works
Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease
Morales, I., Farías, G., & Maccioni, R. B. (2010) · Neuroimmunomodulation · doi:10.1159/000258724 · Cited by 162 · see citing works
Self-citationBlack Garlic and Its Bioactive Compounds on Human Health Diseases: A Review
Ahmed, T., & Wang, C. (2021) · Molecules · doi:10.3390/molecules26165028 · Cited by 158 · see citing works
Li, S., & Pu, X. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1291 · Cited by 157 · see citing works
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice
Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 154 · see citing works
Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans
Lee, J., & Mitchell, A. E. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3001857 · Cited by 152 · see citing works
Cheng, C.-Y., Ho, T., Lee, E.-J., Su, S.-Y., Tang, N.-Y., & Hsieh, C. (2008) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x08006570 · Cited by 147 · see citing works
Zhang, J., Wu, J., Liu, F., Tong, L., Chen, Z., Chen, J., He, H., Xu, R., Ma, Y., & Huang, C. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172500 · Cited by 147 · see citing works
Sun, J., Liu, S., Ling, Z., Wang, F., Ling, Y., Gong, T., Fang, N., Ye, S., Si, J., & Liu, J. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b07313 · Cited by 145 · see citing works
Palmitoylethanolamide: A Natural Compound for Health Management
Clayton, P., Hill, M., Bogoda, N. O., Subah, S., & Venkatesh, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105305 · Cited by 145 · see citing works
Nutraceuticals in cognitive impairment and Alzheimer’s disease
Mecocci, P., Tinarelli, C., Schulz, R. J., & Polidori, M. C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00147 · Cited by 144 · see citing works
McNamara, R. K., Kalt, W., Shidler, M. D., McDonald, J. E., Summer, S. S., Stein, A. L., Stover, A. N., & Krikorian, R. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.12.003 · Cited by 139 · see citing works
Inanami, O., Watanabe, Y., Syuto, B., Nakano, M., Tsuji, M., & Kuwabara, M. (1998) · Free Radical Research · doi:10.1080/10715769800300401 · Cited by 135 · see citing works
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?
Cirmi, S., Ferlazzo, N., Lombardo, G. E., Ventura-Spagnolo, E., Gangemi, S., Calapai, G., & Navarra, M. (2016) · Molecules · doi:10.3390/molecules21101312 · Cited by 129 · see citing works
New Frontiers in the Prevention, Diagnosis, and Treatment of Alzheimer’s Disease
Guzmán‐Martínez, L., Calfío, C., Farias, G. A., Vilches, C., Prieto, R., & Maccioni, R. B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201059 · Cited by 111 · see citing works
Self-citationNeuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury
Li, Y., Shi, W., Li, Y., Zhou, Y., Hu, X., Song, C., Ma, H., Wang, C., & Li, Y. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2007.12.008 · Cited by 109 · cited 1× · see citing works
“In this study, chlorogenic acid prevents the generation of reactive-oxygen species (ROS), suppressing the decreasing action of glutathione peroxidase (GPx) and Glutathione (GSH) and attenuating apoptosis by the activation of caspase-3 [55] (Figure 3).”
BackgroundConstante, M., Fragoso, G., Lupien‐Meilleur, J., Calvé, A., & Santos, M. M. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001089 · Cited by 107 · see citing works
Ray, B., B. Chauhan, N., & K. Lahiri, D. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711796504664 · Cited by 100 · see citing works
Han, D., Li, Z., Liu, T., Yang, N., Li, Y., He, J., Qian, M., Kuang, Z., Zhang, W., Ni, C., et al. (2020) · Aging and Disease · doi:10.14336/ad.2020.0106 · Cited by 99 · see citing works
Complexation of Apple Antioxidants: Chlorogenic Acid, Quercetin and Rutin by β-Cyclodextrin (β-CD)
́Álvarez-Parrilla, E., la Rosa, L. A. D., Torres-Rivas, F., Rodrigo-García, J., & González-Aguilar, G. A. (2005) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-005-1620-z · Cited by 96 · see citing works
Montero‐Odasso, M., Ismail, Z., & Livingston, G. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00646-x · Cited by 95 · see citing works
Calfío, C., González, A., Singh, S. K., Rojo, L. E., & Maccioni, R. B. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200443 · Cited by 94 · see citing works
Self-citationThe microbiota-gut-brain axis: Focus on the fundamental communication pathways
Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works
Biomarkers for Alzheimer’s Disease
Guzman-Martinez, L., Maccioni, R. B., Farías, G. A., Fuentes, P., & Navarrete, L. P. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190517121140 · Cited by 87 · see citing works
Self-citationChiu, H., Venkatakrishnan, K., & Wang, C. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.03.008 · Cited by 86 · see citing works
Xu, B., Li, X., He, G., Hu, J., Mu, X. L., Tian, S., & Du, G. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.038 · Cited by 80 · see citing works
Pandey, J., Bastola, T., Tripathi, J., Tripathi, M., Rokaya, R. K., Dhakal, B., Rabin, D. C., Bhandari, R., & Poudel, A. (2020) · Journal of Food Quality · doi:10.1155/2020/8853426 · Cited by 69 · see citing works
Ávila, P. F., Cairo, J. P. L. F., Damásio, A., Forte, M. B. S., & Goldbeck, R. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108702 · Cited by 69 · see citing works
Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation
Koh, P. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.012 · Cited by 67 · see citing works
Cheng, H., Hsieh, M., Tsai, F., Wu, C., Chiu, C., Lee, M., Xu, H., Zhao, Z., & Peng, W. (2009) · Phytotherapy Research · doi:10.1002/ptr.2940 · Cited by 65 · see citing works
Marefati, N., Beheshti, F., Memarpour, S., Bayat, R., Shafei, M. N., Sadeghnia, H. R., Ghazavi, H., & Hosseini, M. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155107 · Cited by 60 · see citing works
Polyphenols as Possible Markers of Botanical Origin of Honey
Gašić, U. M., Milojković‐Opsenica, D., & Tešić, Ž. (2017) · Journal of AOAC International · doi:10.5740/jaoacint.17-0144 · Cited by 55 · see citing works
Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
Siddiqui, A., Shah, Z., Jahan, R. N., Othman, I., & Kumari, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112250 · Cited by 54 · see citing works
Hattori, M., Sugino, E., Minoura, K., In, Y., Sumida, M., Taniguchi, T., Tomoo, K., & Ishida, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.001 · Cited by 53 · see citing works
Sayed, A. S., Gomaa, I. E. O., Bäder, M., & Sayed, N. S. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0801-2 · Cited by 52 · see citing works
Biological Markers of Alzheimers Disease and Mild Cognitive Impairment
Maccioni, R. B., Manuel Lavados, M., Maccioni, C., & Mendoza‐Naranjo, A. (2004) · Current Alzheimer Research · doi:10.2174/1567205043332018 · Cited by 43 · see citing works
Self-citationSayed, N. S. E., Kandil, E. A., & Ghoneum, M. H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.666502 · Cited by 36 · see citing works
The Alz-tau Biomarker for Alzheimer’s Disease: Study in a Caucasian Population
Guzmán‐Martínez, L., Tapia, J. P., Farias, G. A., González, A., Estrella, M., & Maccioni, R. B. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180637 · Cited by 24 · see citing works
Self-citationKim, H.-S., Sul, D., Lim, J.-Y., Lee, D., Joo, S. S., Hwang, K. W., & Park, S. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90032 · Cited by 23 · see citing works
Guzman-Martinez, L., Farías, G. A., Tapia, J. P., Sánchez, M. P., Fuentes, P., Gloger, S., & Maccioni, R. B. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-201501 · Cited by 21 · see citing works
Self-citationBenefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action (Review)
Sripanidkulchai, B. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8390 · Cited by 19 · see citing works
Andrade, V., Cortés, N., Pastor, G., González, A., Ramos-Escobar, N., Pastene, E., Rojo, L. E., & Maccioni, R. B. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200067 · Cited by 19 · see citing works
Self-citationAuthor Correction: Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Sáez-Atiénzar, S., & Masliah, E. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0366-3 · Cited by 11 · see citing works
Andrade, V., Guzmán‐Martínez, L., Cortés, N., González, A., Farias, G. A., & Maccioni, R. B. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000456 · Cited by 3 · see citing works
Self-citationEssa, M. M., Akbar, M. D., & Guillemin, G. J. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_24 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [17]Essa M.M. Akbar M. Guillemin G. The Benefits of Natural Products for Neurodegenerative Diseases, 1 ed. Springer Cham, Switzerland 2016 496
- [19]Gupta R.C. Lall R. Srivastava A. Nutraceuticals Efficacy, Safety and Toxicity 2nd ed. Academic Press Cambridge, MA, USA 2021 1396
Cited by
Sorted by citations
Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“In addition, natural formulas with anti-inflammatory activity have been developed to treat AD.(543) Neurodegenerative diseases involve complex immune regulation, which makes them difficult to treat with mono-target therapy.”
BackgroundNatural Compounds and Products from an Anti-Aging Perspective
Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sărac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022) · Molecules · doi:10.3390/molecules27207084 · Cited by 231 · see citing works
Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action
Bellavite, P. (2023) · Antioxidants · doi:10.3390/antiox12020280 · Cited by 217 · see citing works
Feng, J., Zheng, Y., Guo, M., Arés, I., Martínez, M., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.010 · Cited by 181 · see citing works
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease
Wang, M., Zhang, H., Liang, J., Huang, J., & Chen, N. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02753-6 · Cited by 149 · see citing works
Barreca, M. M., Alessandro, R., & Corrado, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119236 · Cited by 90 · see citing works
Wong-Guerra, M., Calfío, C., Maccioni, R. B., & Rojo, L. E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1161850 · Cited by 92 · see citing works
Self-citationNagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
Lippi, L., Uberti, F., Folli, A., Turco, A., Curci, C., D’Abrosca, F., Alessandro de, S. I. R. E., & Invernizzi, M. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02203-y · Cited by 43 · see citing works
Anti-Aging Effect of Traditional Plant-Based Food: An Overview
Das, G., Kameswaran, S., Ramesh, B., Manjunatha, B., Nath, R., Talukdar, A. D., Shin, H., & Patra, J. K. (2024) · Foods · doi:10.3390/foods13233785 · Cited by 33 · see citing works
Sun, C., Zhang, S., Ba, S., Dang, J., Ren, Q., Zhu, Y., Liu, K., & Jin, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.901953 · Cited by 28 · see citing works
“They can work within the processes associated with AD (Kaur et al., 2022; Maccioni et al., 2022).”
BackgroundPrevention of Alzheimer's disease through diet: An exploratory review
Bhuiyan, N. Z., Hasan, M. K., Mahmud, Z., Hossain, M. S., & Rahman, A. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100257 · Cited by 31 · see citing works
Liu, C., Zhang, L., Li, Y., Li, M., Han, H., & Wang, K. (2023) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x2350026x · Cited by 22 · see citing works
Nikolaeva, N. S., Yandulova, E. Y., Aleksandrova, Y. R., Starikov, A. S., & Неганова, М. Е. (2022) · Acta Naturae · doi:10.32607/actanaturae.11723 · Cited by 14 · see citing works
González, A., Calfío, C., Lüttges, V., González-Madrid, A., & Guzmán, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230150 · Cited by 14 · see citing works
Self-citationWu, Y., Shao, Y., Shao, X., Yu, H., Wang, M., Wang, J., She, Y., Liu, J., Zhang, T., Li, Z., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145427 · Cited by 14 · see citing works
Li, X., Ichiba, Y., Watanabe, T., Yoshino, A., Cheng, L., Nagasato, Y., Takata, F., Dohgu, S., Iwasaki, K., Tanaka, M., et al. (2024) · npj Science of Food · doi:10.1038/s41538-024-00360-0 · Cited by 13 · see citing works
Li, S., Li, Y., Sun, W., Qin, Z., Lu, Y., Song, Y., Ga, M., Yuan, F., & Liu, Q. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116364 · Cited by 13 · see citing works
Chen, Z., Liu, S., Zhou, H., Wang, M., Pei, S., Wang, R., & Liu, Z. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115930 · Cited by 12 · see citing works
Ryu, M. S., Yu, Y., Li, C., Yang, H.-J., Zhang, T., Wu, X., Jeong, D., & Park, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117091 · Cited by 8 · see citing works
Oligomeropathies, inflammation and prion protein binding
Forloni, G., Vitola, P. L., & Balducci, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.822420 · Cited by 8 · see citing works
Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease
Andrade, V., Wong-Guerra, M., Cortés, N., Pastor, G., González, A., Calfío, C., Guzmán‐Martínez, L., Navarrete, L. P., Ramos-Escobar, N., Morales, I., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16070960 · Cited by 8 · see citing works
Self-citationWang, X., Fu, X., Luo, X., Lai, Y., Cai, C., Liao, Y., Dai, Z., Fang, S., & Fang, J. (2023) · Molecules · doi:10.3390/molecules29010021 · Cited by 8 · see citing works
Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats
Behrad, S., Pourranjbar, S., Pourranjbar, M., Abbasi-Maleki, S., Mehr, S. R., Salmani, R. H. G., & Moradikor, N. (2024) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/apjtb.apjtb_294_24 · Cited by 7 · see citing works
O'Day, D. (2023) · Biomolecules · doi:10.3390/biom13040678 · Cited by 7 · see citing works
Current status of prevention strategies adapted for Alzheimer's disease
Singh, A., Sethi, P., Ghosh, S., Singh, D. K. K., Rohatgi, S., Singh, P. K., & Sinha, J. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15540-6.00004-5 · Cited by 5 · see citing works
Kumar, A., Ali, R., Kumar, R., & Chawla, P. A. (2022) · Pharmaspire · doi:10.56933/pharmaspire.2022.14106 · Cited by 4 · see citing works
hamzekolaei, F. Z., Moghaddam, A. H., Ghanbarzadeh, M., Nazifi, E., & Jelodar, S. K. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.05.039 · Cited by 3 · see citing works
Moringa oleifera Extracts as Strategic Phyto‐Therapy for Alzheimer's Disease
Carrotta, R., Vilasi, S., Costa, M. A., Librizzi, F., Martorana, V., Passantino, R., Buzzanca, C., Stefano, V. A. D., Ortore, M. G., Piccirillo, S., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70007 · Cited by 3 · see citing works
Rao, J., Zheng, H., Lu, M., Chen, J., Wang, C., & Cao, Y. K. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106837 · Cited by 2 · see citing works
Nutraceuticals and natural products in the treatment of neurological disorders
Shivaprasad, H. N., Sravani, T., Preethi, P., Soni, G., & Krishnamani, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00004-8 · Cited by 1 · see citing works
From the hive to the brain: synergistic potential of honeybee products with alzheimer’s drugs
El-Seedi, H. R., Salama, S. M., Shetaia, A. A., Elashal, M. H., El‐Wahed, A. A. A., Karav, S., Saeed, A., Alzahrani, M. A., Zou, X., Hriţcu, L., et al. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01727-2 · Cited by 1 · see citing works
Role of Nutraceuticals in the Prevention and Management of Degenerative Diseases
Sarkar, B. R., Giri, S., Dey, G., & Ghosh, N. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898812553125010007 · Cited by 1 · see citing works
Thongdechsri, S., Kamonnat, C., Sanguanphun, T., Kraokaew, P., Jattujan, P., Niamnont, N., Smith, S. J., Cummins, S. F., Jongkamonwiwat, N., Sobhon, P., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108427 · Cited by 1 · see citing works
Antioxidant and neuroregenerative roles of Allium sativum L. in promoting central nervous health
Juman, M., Almasaad, M., Alsharif, M. H. K., f, N. O. E., Algamdi, M. A., Aldabbagh, K., Felemban, R. A., & Bakhit, N. M. (2024) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2024.13.1.8
Nutrition and Degenerative Brain Dysfunctions
Bell, V., & Fernandes, T. H. (2023) · European journal of applied sciences · doi:10.14738/aivp.111.13720
Gören, A. C., & Öztürk, M. (2023) · Records of Agricultural and Food Chemistry · doi:10.25135/rfac.16.2303.0001
Nutraceuticals in the prevention and treatment of Alzheimer's disease
Mishra, D. K., Mishra, S. K., Asthana, A., Audah, K. A., Singh, M. P., & Singh, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15540-6.00008-2
Sharma, S., Johari, S., & Dang, S. (2024) · International Conference on Contemporary Computing · doi:10.1145/3675888.3676042
Progress and Trends on Delphinidin During 1993-2023: A Bibliometric Analysis
Yu, X., Jiang, H., Wang, M., Yang, J., & Zhang, Z. (2024) · Natural Product Communications · doi:10.1177/1934578x241302008
Kai-Feng, S. U. N., Choi, C. H., Yoon, Y.-S., & Lee, K.-I. (2025) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2025.33.4.211
Xu, L. X., Gong, X., Chen, Y., Chen, Y., Luo, T., & Zhang, X. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag055
Kumar, A., & Verma, V. (2026) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2026.100831
- Authors
- Maccioni, R. B., Calfío, C., González, A., & Lüttges, V.
- Affiliations
- University of Chile (CL)
- Corresponding author
- Maccioni, Ricardo Benjamin
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2022-02-03
- Volume
- 12
- Issue
- 2
- Pages
- 249
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC8961630
- OpenAlex
- W4210560908
- Cited by
- 45
- References
- 87
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 12 · 2023: 17 · 2022: 6
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agencia Nacional de Investigación y Desarrollo (i7819020001, ID19I10301)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, nutraceuticals, Alzheimer's disease prevention, Mediterranean diet, bioactive compounds, antioxidant activity, anti-inflammatory agents, protein aggregation, quercetin, Shilajit, anthocyanidins, flavonoids, hydroxytyrosol, early biomarkers, dementia, physical activity, cognitive stimulation, nutrition
- MeSH terms
- Alzheimer Disease, Antioxidants, Humans, Dietary Supplements, Diet, Mediterranean, Cognitive Dysfunction
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