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Cited by 208Pesticide Exposure and ToxicityParaquat toxicity studies and treatmentsDrug-Induced Hepatotoxicity and Protection

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate

El-Shenawy, Nahla S.·2009·Environmental Toxicology and Pharmacology
DOI 10.1016/j.etap.2009.06.001
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Abstract

Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated with sub-lethal concentration of Roundup (269.9mg/kg) or glyphosate (134.95mg/kg) each 2 days, during 2 weeks. Hepatotoxicity was monitored by quantitative analysis of the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities, total protein, albumin, triglyceride and cholesterol. Creatinine and urea were used as the biochemical markers of kidney damages. The second aim of this study to investigate how glyphosate alone or included in herbicide Roundup affected hepatic reduced glutathione (GSH) and lipid peroxidation (LPO) levels of animals as an index of antioxidant status and oxidative stress, respectively, as well as the serum nitric oxide (NO) and alpha tumour necrosis factor (TNF-α) were measured. Treatment of animals with Roundup induced the leakage of hepatic intracellular enzymes, ALT, AST and ALP suggesting irreversible damage in hepatocytes starting from the first week. It was found that the effects were different on the enzymes in Roundup and glyphosate-treated groups. Significant time-dependent depletion of GSH levels and induction of oxidative stress in liver by the elevated levels of LPO, further confirmed the potential of Roundup to induce oxidative stress in hepatic tissue. However, glyphosate caused significant increases in NO levels more than Roundup after 2 weeks of treatment. Both treatments increased the level of TNF-α by the same manner. The results suggest that excessive antioxidant disruptor and oxidative stress is induced with Roundup than glyphosate.

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  1. U.S.E.P.A., 1993. Department of Health and Human Service, Public Health Service, National Institutes of Health, NTP Technical Report on Toxicity Studies of Glyphosate (CAS No. 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice (NIH Publication 92-3135). Toxicity Reports Series No. 16. National Toxicology Program, U.S.E.P.A., Research Triangle Park, NC. Office of Pesticide Programs. Special Review and Registration Division. Registration Eligibility Decision (RED): Glyphosate, Washington, DC.

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Metadata

Authors
El-Shenawy, N. S.
Venue
Environmental Toxicology and Pharmacology
Publisher
Elsevier BV
Published
2009-11
Volume
28
Issue
3
Pages
379-385
ISSN
1382-6689 (ISSN-L)
DOI
10.1016/j.etap.2009.06.001
OpenAlex
W2158634663
Cited by
207
References
39
Citations by year
2026: 16 · 2025: 10 · 2024: 13 · 2023: 16 · 2022: 24 · 2021: 18 · 2020: 18 · 2019: 24 · 2018: 9 · 2017: 12 · 2016: 11 · 2015: 3 · 2014: 16 · 2013: 11 · 2012: 4
FWCI
2.43
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environmental Toxicology and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
glyphosate, Roundup, herbicide toxicity, oxidative stress, hepatotoxicity, reduced glutathione, lipid peroxidation, nitric oxide, TNF-α, antioxidant status, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, kidney injury, rats

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