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Acetyl-l-Carnitine Attenuates Arsenic-Induced Liver Injury by Abrogation of Mitochondrial Dysfunction, Inflammation, and Apoptosis in Rats

Bodaghi-Namileh, Vida, Sepand, Mohammad Reza, Omidi, Ameneh, Aghsami, Mehdi, Seyednejad, Seyed Afshin, Kasirzadeh, Sara, Sabzevari, Omid·2018·Environmental Toxicology and Pharmacology
DOI 10.1016/j.etap.2017.12.005
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Abstract

Industrial and agricultural developments in recent years have resulted in the excessive discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic toxicity. The main objective of this study was to evaluate acetyl-l-carnitine's (ALC) protective ability against the arsenic-induced hepatotoxicity. For this purpose, male Wistar rats were distributed randomly into 5 groups of 8 rats each: control, arsenic (5 mg/kg) and arsenic plus ALC (5 mg/kg; 100, 200, 300 mg/kg). The animals were gavaged for 21 consecutive days. Liver tissue samples were extracted 24 h after the last treatment and were later analyzed for biochemical and histological alterations. The arsenic-induced oxidative damage was confirmed by elevation of malondialdehyde (MDA), a lipid peroxidation byproduct, as well as depletion in physiological antioxidant content such as superoxide dismutase (SOD) and catalase (CAT). Furthermore, alterations in mitochondrial functions including a significant decrease of mitochondrial outer membrane potential and reactive oxygen species (ROS) generation increase, mitochondrial swelling, release of cytochrome c and consequent activation of caspase-3 and caspase-9 and initiation of apoptosis, was observed following arsenic administration. Moreover, the inflammation was confirmed by the overexpression of inflammatory mediators such as NF-ĸB and IL-1 and IL-6. The present study demonstrated…

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Metadata

Authors
Bodaghi-Namileh, V., Sepand, M. R., Omidi, A., Aghsami, M., Seyednejad, S. A., Kasirzadeh, S., & Sabzevari, O.
Venue
Environmental Toxicology and Pharmacology
Publisher
Elsevier BV
Published
2018-03
Volume
58
Pages
11-20
ISSN
1382-6689
DOI
10.1016/j.etap.2017.12.005
Cited by
78
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Vice Chancellor for Research

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