Ecotoxicological Effects of Alpha-Cypermethrin on Freshwater Alga Chlorella Sp.: Growth Inhibition and Oxidative Stress Studies
Abstract
Alpha-cypermethrin (ACy) is a synthetic pyrethroid insecticide commonly used in agricultural practices for controlling a broad range of insect pests particularly belonging to the order Lepidoptera and Coleoptera. The present study aims to evaluate the toxic effect of ACy on microalgae by studying its influence on Chlorella sp. According to our knowledge, this is the first detailed study of ACy toxicity on microalgae. Significant growth inhibition of Chlorella sp. was observed at high ACy concentration (6-48 mg L-1) during the entire 96 h bioassay. The 96 h median effective concentration (EC 50) of ACy was estimated to be 11.00 mg L-1. Flow cytometry analysis showed an enhanced generation of reactive oxygen species (ROS) and intracellular lipid accumulation after 96 h exposure to 11.00 mg L-1 of ACy. Further, the same ACy concentration showed a significant decrease in photosynthetic pigment content and an increase in antioxidant enzyme activity and malondialdehyde (MDA) content in Chlorella sp.
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According to research on alpha-cypermethrin, the lipophilic pyrethroid pesticide toxicity of chlorella exhibits acute and chronic toxicity to the human body, causes insomnia and mental disorders, and may cause DNA mutations.
“According to research on alpha-cypermethrin, the lipophilic pyrethroid pesticide toxicity of chlorella, it is found that toxic reaction to the human body than other pesticides (nausea, vomiting, dizziness), exhibits acute and chronic toxicity, causes insomnia and mental disorders, and may cause DNA mutations [112].”
From Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption (2022) · cites this paper as [112]
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- Authors
- Baruah, P., & Chaurasia, N.
- Affiliations
- North Eastern Hill University (IN)
- Corresponding author
- Chaurasia, Neha
- ORCID
- Chaurasia, Neha
- Venue
- Environmental Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 76
- Pages
- 103347
- ISSN
- 1382-6689 (ISSN-L)
- OpenAlex
- W3003997888
- Cited by
- 47
- References
- 83
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 6 · 2020: 1
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Toxicology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pesticide and Herbicide Environmental Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Keywords
- alpha-cypermethrin, pyrethroid insecticides, Chlorella, microalgae toxicity, growth inhibition, oxidative stress, reactive oxygen species, lipid peroxidation, malondialdehyde, photosynthetic pigments, antioxidant enzymes, freshwater algae, EC50
- MeSH terms
- Chlorella, Dose-Response Relationship, Drug, Pyrethrins, Reactive Oxygen Species, Oxidative Stress
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