Effects of Catalpol on Mitochondrial Function and Working Memory in Mice after Lipopolysaccharide-Induced Acute Systemic Inflammation
Abstract
The aim of this study was to investigate whether catalpol could facilitate recovery from lipopolysaccharide (LPS)-induced cognitive deficits and protect brain mitochondrial function from LPS-induced acute systemic inflammation. In the study, except control group, mice were challenged with a single dose of LPS (100 microg/mouse, i.p.) to mimic an acute peripheral infection. The results showed that LPS enhanced nuclear factor kappa B (NF-kappaB) activation and induced a loss in mitochondrial integrity as shown by a significant decrease in membrane potential and increase in mitochondrial permeability transition pore opening. Pretreatment with catalpol (10 mg/kg d, i.p.) for 10d before injection of LPS reversed the memory deficits induced by LPS, protected brain mitochondrial function, and attenuated LPS-induced NF-kappaB activation. Taken together, these data indicate that catalpol may possess therapeutic potential against LPS-induced acute systemic inflammation by attenuating NF-kappaB activation and protecting mitochondrial function in cerebral cortex and hippocampus.
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Catalpol suppresses neuroinflammation by inhibiting NF-κB activation and reducing iNOS activity in LPS-treated astrocytes and in mice with acute systemic inflammation induced by LPS.
“Several in vitro studies have also shown that catalpol is able to protect astrocytes from H2O2 damage and to suppress neuroinflammation by inhibiting NF-κB activation and reducing iNOS activity in LPS-treated astrocytes and in mice with acute systemic inflammation induced by LPS (Bi et al., 2008; Zhang et al., 2009; Bi et al., 2013).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Zhang et al., 2009
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,091 · see citing works
LeBel, C. P., Ischiropoulos, H., & Bondy, S. C. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00026a012 · Cited by 2,694 · see citing works
Microglia as a source and target of cytokines
Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645 · see citing works
Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.367 · Cited by 1,567 · see citing works
Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095 · see citing works
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813 · see citing works
Emaus, R. K., Grunwald, R., & Lemasters, J. J. (1986) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(86)90112-x · Cited by 805 · see citing works
LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501 · see citing works
Inflammation, autotoxicity and Alzheimer disease
McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 474 · see citing works
Inflammation and Alzheimer's disease: Possible role of periodontal diseases
Kamer, A. R., Craig, R. G., Dasanayake, A. P., Bryś, M., Głodzik-Sobańska, L., & de Leon, M. J. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.08.004 · Cited by 406 · see citing works
Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 396 · see citing works
Cassarino, D. S., Parks, J. K., Parker, W. D., & Bennett, J. P. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00083-0 · Cited by 304 · see citing works
Microglia in diseases of the central nervous system
Nelson, P. T., Soma, L. A., & Lavi, E. (2002) · Annals of Medicine · doi:10.1080/078538902321117698 · Cited by 222 · see citing works
Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice
Kozak, W., Conn, C. A., & Kluger, M. J. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.1.r125 · Cited by 215 · see citing works
Oxidative stress and mitochondrial dysfunction in neurodegeneration
Schapira, A. H. V. (1996) · Current Opinion in Neurology · doi:10.1097/00019052-199608000-00003 · Cited by 200 · see citing works
Structural Considerations on the Iridoids as Anti-Inflammatory Agents
Recio, M. C., Giner, R. M., Máñez, S., & Rı́os, J. L. (1994) · Planta Medica · doi:10.1055/s-2006-959465 · Cited by 192 · see citing works
Mitochondrial involvement in Parkinson's disease
Orth, M. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00124-3 · Cited by 188 · see citing works
Oxidative stress and mitochondrial dysfunction in neurodegeneration; cardiolipin a critical target?
Pope, S. A. S., Land, J. M., & Heales, S. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.011 · Cited by 154 · see citing works
Redox regulation of pro-inflammatory cytokines and IκB-α/NF-κB nuclear translocation and activation
Haddad, J. J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00947-6 · Cited by 148 · see citing works
Veitch, K., HOMBROECKX, A., Caucheteux, D., Pouleur, H. G., & Hue, L. (1992) · Biochemical Journal · doi:10.1042/bj2810709 · Cited by 145 · see citing works
Tian, Y.-Y., An, L., Jiang, L., Duan, Y.-L., Chen, J., & Jiang, B. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.09.010 · Cited by 133 · see citing works
Zhang, X. Y., JIANG, B., LI, Z., HAO, S., & AN, L. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.07.004 · Cited by 128 · see citing works
Hydrogen Peroxide Activates NF κ B and the Interleukin-6 Promoter Through NF κ B-Inducing Kinase
Zhang, J., Johnston, G., Stebler, B. S., & Keller, E. T. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152409121 · Cited by 125 · see citing works
Sharov, V. G., Todor, A. V., Khanal, S., Imai, M., & Sabbah, H. N. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.09.013 · Cited by 112 · see citing works
An, S. J., Pae, H., Oh, G., Choi, B., Jeong, S., Jang, S. I., Oh, H., Kwon, T. O., Song, C. E., & Chung, H. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00085-1 · Cited by 100 · see citing works
Bacterial endotoxin-induced behavioral alterations in two variations of the Morris water maze
Sparkman, N. L., Kohman, R. A., Scott, V. J., & Boehm, G. W. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.07.016 · Cited by 92 · see citing works
Microglial signalling cascades in neurodegenerative disease
Pocock, J. M., & Liddle, A. C. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32103-9 · Cited by 90 · see citing works
Modulation of oxidative events by multivalent manganese complexes in brain tissue
HaMai, D., Campbell, A., & Bondy, S. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00639-6 · Cited by 84 · see citing works
Shibata, N., Ohnuma, T., Takahashi, T., Baba, H., Ishizuka, T., Ohtsuka, M., Ueki, A., Nagao, M., & Arai, H. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10417 · Cited by 80 · see citing works
Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa
Zhang, X., Zhang, A., Jiang, B., Bao, Y., Wang, J., & An, L. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.01.001 · Cited by 79 · see citing works
Avitsur, R., Pollak, Y., & Yirmiya, R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00927-x · Cited by 73 · see citing works
Godbout, J. P., Berg, B. M., Krzyszton, C. P., & Johnson, R. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.003 · Cited by 71 · see citing works
Noble, F., Rubira, E., Boulanouar, M., Palmier, B., Plotkine, M., Warnet, J., Marchand‐Leroux, C., & Massicot, F. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.005 · Cited by 69 · see citing works
Neuroprotection of catalpol in transient global ischemia in gerbils
Li, D.-Q., Duan, Y.-L., Bao, Y.-M., Liu, C.-P., Liu, Y., & An, L. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.06.009 · Cited by 66 · see citing works
Catalpol attenuates the neurotoxicity induced by β-amyloid1–42 in cortical neuron–glia cultures
Jiang, B., Du, J., Liu, J., Bao, Y., & An, L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.105 · Cited by 65 · see citing works
Mao, Y.-R., Jiang, L., Duan, Y.-L., An, L., & Jiang, B. (2006) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2006.11.012 · Cited by 52 · see citing works
Li, D., Li, Y., Liu, Y., Bao, Y., Hu, B., & An, L. (2005) · Toxicon · doi:10.1016/j.toxicon.2004.09.007 · Cited by 48 · see citing works
Haddad, J. J., Safieh‐Garabedian, B., Saadé, N. E., & Lauterbach, R. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00117-0 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cognitive dysfunction with aging and the role of inflammation
Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. A., & Barry, L. C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311399145 · Cited by 174 · see citing works
Feng, S., Zou, L., Wang, H., He, R., Liu, K., & Zhu, H. (2018) · Molecules · doi:10.3390/molecules23092371 · Cited by 130 · see citing works
Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling
Zhang, H., Wu, Z., Yang, Y., Shaukat, A., Yang, J., Guo, Y., Zhang, T., Zhu, X., Qiu, J., Deng, G., et al. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900071 · Cited by 111 · see citing works
Hu, H., Wang, C., Jin, Y., Meng, Q., Liu, Q., Liu, Z., Liu, K., Liu, X., & Sun, H. (2018) · Inflammation · doi:10.1007/s10753-018-0873-9 · Cited by 103 · see citing works
Traditional Chinese Medicine for Senile Dementia
Lin, Z., Gu, J., Xiu, J., Mi, T., Dong, J., & Tiwari, J. K. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/692621 · Cited by 98 · see citing works
Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain
Yan, W., Ji, X., Shi, J., Li, G., & Sang, N. (2015) · Environmental Research · doi:10.1016/j.envres.2015.02.022 · Cited by 91 · see citing works
Savi, F. F., de Oliveira, A. L. R., de Medeiros, G. F., Bozza, F. A., Michels, M., Sharshar, T., Dal‐Pizzol, F., & Ritter, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.005 · Cited by 79 · see citing works
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Li, X., Xu, Z., Jiang, Z., Sun, L., Ji, J., Miao, J., Zhang, X., Li, X., Huang, S., Wang, T., et al. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu065 · Cited by 65 · see citing works
Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice
Fu, K., Piao, T., Wang, M., Zhang, J., Jiang, J., Wang, X., & Liu, H. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.07.011 · Cited by 62 · see citing works
Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures
Bi, J., Jiang, B., Zorn, A., Zhao, R.-G., Liu, P., & An, L. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.09.023 · Cited by 51 · see citing works
Oku, H., Ogawa, Y., Iwaoka, E., & Ishiguro, K. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1330 · Cited by 48 · see citing works
Zhang, X., Liu, K., Shi, M., Xie, L., Deng, M., Chen, H., & Li, X. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.020 · Cited by 46 · see citing works
Fei, B., Dai, W., & Zhao, S. (2018) · Medical Science Monitor · doi:10.12659/msm.907569 · Cited by 42 · see citing works
Zhu, J., Chen, X., Wang, H., & Yan, Q. (2015) · PubMed Central · Cited by 41 · see citing works
Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice
Huang, J., WU, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., & Hua, F. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4496 · Cited by 37 · see citing works
The therapeutic efficacy of glutamine for rats with smoking inhalation injury
Li, W., Qiu, X., Wang, J., Li, H., Sun, Y., Zhang, F., Jin, H., Fu, J., & Xia, Z. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.02.022 · Cited by 36 · see citing works
Wang, G., Liu, B., Cao, Y., Du, Y., Zhang, H., Luo, Q., Li, B., Wu, J., Lv, Y., Sun, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103168 · Cited by 35 · see citing works
Xiao, W. Q., Yin, G., Yu, F., Qiu, L., Cang, X., Yu, G., Hu, Y. L., Xing, M., Wu, D., Wang, X., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150711957 · Cited by 33 · see citing works
Regulatory Effect of Catalpol on Th1/Th2 cells in Mice with Bone Loss Induced by Estrogen Deficiency
Lai, N., Zhang, J., Ma, X., Wang, B., Miao, X., Wang, Z., Guo, Y., Wang, L., Yao, C., Li, X., et al. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12423 · Cited by 33 · see citing works
Zhang, J., Zhu, W., Xu, X., & Zhang, Z. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.02.017 · Cited by 31 · see citing works
Tao, J., Zhao, M., Wang, D., Yang, C., Du, L., Qiu, W., & Jiang, S. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.12.007 · Cited by 31 · see citing works
Jin, X., Guo, J., Wang, L., Zhong, X., Yao, W., Gao, H., & Liu, M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113401 · Cited by 29 · see citing works
Park, K. S. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-0988-y · Cited by 26 · see citing works
Feng, Y., Liu, Z., Peng, Y., Zhang, L., Ju, P., Kai-shun, B., & Chen, X. (2013) · Biomedical Chromatography · doi:10.1002/bmc.2949 · Cited by 26 · see citing works
Choi, Y. H. (2019) · General Physiology and Biophysics · doi:10.4149/gpb-2018044 · Cited by 26 · see citing works
Priber, J. K., Fonai, F., Jakus, P., Rácz, B., Chinopoulos, C., Tretter, L., Gallyas, F., Sümegi, B., & Veres, B. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0120 · Cited by 24 · see citing works
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Wang, Y., Shao, Y., Gao, Y., Wan, G., Wan, D., Zhu, H., Qiu, Y., & Ye, X. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s188968 · Cited by 19 · see citing works
The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury
Qiu, X., Ji, S., Wang, J., Li, H., Xia, T., Pan, B., Xiao, S., & Xia, Z. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.08.002 · Cited by 17 · see citing works
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Li, Z., Dong, K., Zhang, Y., Ju, E., Chen, Z., Ren, J., & Qu, X. (2015) · Chemical Communications · doi:10.1039/c5cc06794d · Cited by 16 · see citing works
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Chen, D., Guo, J., & Li, L. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1727927 · Cited by 13 · see citing works
Antiangiogenic effects of catalpol on rat corneal�neovascularization
Han, Y., Shen, M., Tang, L., Tan, G., Yang, Q., Ye, L., Ye, L., Jiang, N., Gao, G., & Shao, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8114 · Cited by 11 · see citing works
Bi, J., Li, J., Chen, S., Rao, J.-K., Xie, Y., Yang, H., Wang, L., & Cheng, B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.05.050 · Cited by 8 · see citing works
Zhang, Y., Wang, C., Yang, Q., Jin, Y., Meng, Q., Liu, Q., Dai, Y., Liu, Z., Liu, K., & Sun, H. (2017) · RSC Advances · doi:10.1039/c7ra09085d · Cited by 7 · see citing works
Iridoid glycosides of the tribe Antirrhineae
Сокорнова, С. В., & Matveeva, T. V. (2021) · Phytochemistry Reviews · doi:10.1007/s11101-021-09774-0 · Cited by 6 · see citing works
Improved Myocardial Function With Supplement of Levosimendan to Celsior Solution
Zhou, H., Zhang, L., Zheng, M., Wang, L., Chen, Y., & Shen, Y. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000115 · Cited by 4 · see citing works
Soualeh, N., Soulimani, R., & Bouayed, J. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.08.019 · Cited by 4 · see citing works
Wu, B., Dong, Q., Zhang, Q., Jin, F., & Weng, J. (2025) · Clinical Rheumatology · doi:10.1007/s10067-024-07261-3 · Cited by 3 · see citing works
Catapol: a promising natural neuroprotective agent for neurologic disorders
Li, W., & Zhou, X. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0097 · Cited by 3 · see citing works
Zhang, Y., & Xu, P. (2024) · The Thai Journal of Veterinary Medicine · doi:10.56808/2985-1130.3729 · Cited by 3 · see citing works
Wang, T., Shao, C., An, H., Xu, G., Wan, H., & Yang, J. (2025) · ACS Omega · doi:10.1021/acsomega.4c11357 · Cited by 2 · see citing works
Le, A. C. D., El-Khatib, S. M., Tran, B. M., Chan, F. P., Chan, A., & Acharya, M. M. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158372 · Cited by 1 · see citing works
Fever and sickness behaviour during simulated Mycoplasma infection in rats
Swanepoel, T. (2013) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Mani, V., Arfeen, M., Abde, A.-M. H., & Ali, H. M. (2022) · International Journal of Pharmacology · doi:10.3923/ijp.2022.407.414
Soualeh, N. (2017) · theses.fr (ABES) · doi:10.70675/035f2418z4137z4706zb59az81d97410d751
- Authors
- Zhang, A., Hao, S., Bi, J., Bao, Y., Zhang, X., An, L., & Jiang, B.
- Affiliations
- Dalian University of Technology (CN)
- Binzhou Medical University (CN)
- Corresponding author
- Jiang, Bo
- Venue
- Experimental and Toxicologic Pathology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 61
- Issue
- 5
- Pages
- 461-469
- ISSN
- 0940-2993 (ISSN-L)
- OpenAlex
- W2039383760
- Cited by
- 46
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Toxicologic Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- catalpol, lipopolysaccharide, acute systemic inflammation, working memory, mitochondrial function, NF-κB activation, mitochondrial permeability transition pore, mitochondrial membrane potential, neuroprotection, cognitive impairment, hippocampus, cerebral cortex, peripheral infection
- MeSH terms
- Animals, Anti-Inflammatory Agents, Brain, Glucosides, Inflammation, Lipopolysaccharides, Memory, Mitochondria, NF-kappa B, Maze Learning, Iridoids, Mice, Iridoid Glucosides
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