Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works

Phylogenetic perspectives in innate immunity.

Hoffmann, J., Kafatos, F., Janeway, C., & Ezekowitz, R. A. (1999) · Science · doi:10.1126/science.284.5418.1313 · Cited by 2,617 · see citing works

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045 · see citing works

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,394 · see citing works

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,137 · see citing works

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · cited 2× · see citing works

Cytology & cellular pathology of the nervous system

Penfield, W. G. (1965) · Medical Entomology and Zoology · Cited by 1,035 · see citing works

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

Dickson, D. W., Lee, S. C., Mattiace, L. A., Yen, S.-H. C., & Brosnan, C. F. (1993) · Glia · doi:10.1002/glia.440070113 · Cited by 821 · see citing works

Inflammation and glial responses in ischemic brain lesions

Stoll, G. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00034-3 · Cited by 794 · see citing works

Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease

Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789 · see citing works

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

Boje, K. M., & Arora, P. K. (1992) · Brain Research · doi:10.1016/0006-8993(92)91004-x · Cited by 786 · see citing works

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743 · see citing works

Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works

Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

Hsu, H.-Y., & Wen, M.-H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111883200 · Cited by 519 · cited 2× · see citing works

Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439 · see citing works

Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration

Liu, B., Gao, H., Wang, J., Jeohn, G., Cooper, C. L., & Hong, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04077.x · Cited by 425 · see citing works

Interleukin-1 and Tumor Necrosis Factor-α Synergistically Mediate Neurotoxicity: Involvement of Nitric Oxide and of N-Methyl-D-aspartate Receptors

Chao, C. C., Hu, S. X., Ehrlich, L., & Peterson, P. K. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1033 · Cited by 412 · see citing works

Neuroinflammation of the nigrostriatal pathway during progressive 6‐OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging

Cicchetti, F., Brownell, A., Williams, K. S., Chen, Y. I., Livni, E., & Ole Isacson, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01938.x · Cited by 406 · see citing works

Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

Sanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102061200 · Cited by 395 · see citing works

Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works

Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation

Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 352 · see citing works

Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation

Liu, B., Du, L., & Hong, J.-S. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39275-4 · Cited by 347 · cited 9× · see citing works

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

Dehmer, T., Lindenau, J. H., Haid, S., DICHGANS, J., & Schulz, J. B. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742213.x · Cited by 337 · see citing works

Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?

Vallance, P. J., Collier, J., & Bhagat, K. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09424-x · Cited by 308 · see citing works

The origin and differentiation of microglial cells during development

Cuadros, M. Á. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00035-5 · Cited by 305 · see citing works

Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

Qin, L., Liu, Y., Cooper, C. L., Liu, B., Wilson, B. C., & Hong, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01210.x · Cited by 290 · see citing works

The microglial cell. A historical review

Barron, K. D. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00209-k · Cited by 279 · see citing works

Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide _1–42 - and Lipopolysaccharide-Activated Microglia

Xie, Z., Wei, M., Morgan, T. E., Fabrizio, P., Han, D., Finch, C. E., & Longo, V. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03484.2002 · Cited by 272 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Greenamyre, J. T., MacKenzie, G. M., Peng, T., & Stephans, S. E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660085 · Cited by 248 · see citing works

Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.

Iravani, M. M., Kashefi, K., Mander, P., Rose, S., & Jenner, P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00562-0 · Cited by 247 · see citing works

In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain

Ling, Z., Gayle, D. A., Ma, S. Y., Lipton, J. W., Tong, C. W., Hong, J., & Carvey, P. M. (2002) · Movement Disorders · doi:10.1002/mds.10078 · Cited by 241 · see citing works

The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh‐TNF‐α, IL‐1β and IFN‐γ

Castaño, A., Herrera, A. J., Cano, J., & Machado, A. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00799.x · Cited by 239 · see citing works

Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons

McGuire, S. O., Ling, Z. D., Lipton, J. W., Sortwell, C. E., Collier, T. J., & Carvey, P. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7688 · Cited by 222 · see citing works

Brain injury in a dish: a model for reactive gliosis

McMillian, M., Thai, L., Hong, J., O'Callaghan, J. P., & Pennypacker, K. R. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90086-8 · Cited by 201 · see citing works

Multiple Sclerosis: Immune System Molecule Expression in the Central Nervous System

Raine, C. S. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199407000-00002 · Cited by 198 · see citing works

Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures

Jeohn, G., Kong, L., Wilson, B. C., Hudson, P. M., & Hong, J. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00204-x · Cited by 186 · see citing works

Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures

Bronstein, D. M., Pérez‐Otaño, I., Sun, V., Sawin, S. B. M., Chan, J., Wu, G.-C., Hudson, P. M., Kong, L., Hong, J., & McMillian, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)01189-7 · Cited by 186 · see citing works

Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide

Liu, B., Jiang, J., Wilson, B. C., Du, L., Yang, S., Wang, J., Wu, G.-C., Cao, X.-D., & Hong, J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38877-9 · Cited by 167 · see citing works

The Role of Microglia and Astrocytes in Cns Immune Surveillance and Immunopathology

Aloisi, F. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4685-6_10 · Cited by 154 · see citing works

Cyclooxygenase-2 Inhibitor NS-398 Protects Neuronal Cultures From Lipopolysaccharide-Induced Neurotoxicity

Araki, E., Forster, C. L., Dubinsky, J. M., Ross, M. E., & Iadecola, C. (2001) · Stroke · doi:10.1161/hs1001.096057 · Cited by 126 · see citing works

Postencephalitic parkinsonism – a review

Casals, J., Elizan, T. S., & Yahr, M. D. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050086 · Cited by 105 · see citing works

Microglia and prion disease

Brown, D. R. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1122 · Cited by 100 · see citing works

Inhibition by Naloxone Stereoisomers of β-Amyloid Peptide (1–42)-induced Superoxide Production in Microglia and Degeneration of Cortical and Mesencephalic Neurons

Liu, Y., Qin, L., Wilson, B. C., An, L., Hong, J., & Liu, B. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035956 · Cited by 94 · see citing works

Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats

Lu, X., Bing, G., & Hagg, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00033-6 · Cited by 89 · see citing works

Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron–glia co-cultures

Liu, B., Du, L., Kong, L., Hudson, P. M., Wilson, B. C., Chang, R. C., Abel, H. H., & Hong, J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00057-9 · Cited by 85 · see citing works

Trauma as an etiology of parkinsonism: A historical review of the concept

Factor, S. A., Sanchez‐Ramos, J., & Weiner, W. J. (1988) · Movement Disorders · doi:10.1002/mds.870030105 · Cited by 79 · see citing works

The clinical potential of cyclooxygenase-2–specific inhibitors

Lipsky, P. E. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00117-5 · Cited by 76 · see citing works

A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy

Chang, R. C., Rota, C., Glover, R. E., Mason, R. P., & Hong, J. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02267-2 · Cited by 73 · see citing works

Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over‐activation by LPS

Chang, R. C., Chen, W., Hudson, P. M., Wilson, B. C., Han, D. S. K., & Hong, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00111.x · Cited by 69 · see citing works

Reactive oxygen species mediate A??(25-35)-induced activation of BV-2 microglia

Kang, J., Park, E. J., Jou, I., Kim, J., & Joe, E.-H. (2001) · Neuroreport · doi:10.1097/00001756-200105250-00030 · Cited by 68 · see citing works

Inhibition of Lipopolysaccharide-Induced Nitric Oxide and Cytokine Production by Ultralow Concentrations of Dynorphins in Mixed Glia Cultures

Kong, L., McMillian, M., Hudson, P. M., Jin, L., & Hong, J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36393-1 · Cited by 66 · see citing works

Medial prefrontal cortical output neurons to the ventral tegmental area (VTA) and their responses to burst-patterned stimulation of the VTA: Neuroanatomical and in vivo electrophysiological analyses

Young, S. A., Shen, H., & Yang, C. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19991215)34:4 · Cited by 51 · see citing works

Naloxone inhibits superoxide release from human neutrophils

Simpkins, C., Ives, N., Tate, E. A., & Johnson, M. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90076-1 · Cited by 45 · see citing works

Modulatory effects of [Met5]-enkephalin on interleukin-1β secretion from microglia in mixed brain cell cultures

Das, K. P., McMillian, M., Bing, G., & Hong, J. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00083-e · Cited by 44 · see citing works

Immune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia

Chang, R. C., Hudson, P. M., Wilson, B. C., Liu, B., Abel, H., Hemperly, J. J., & Hong, J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00175-3 · Cited by 19 · see citing works

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works

Inflammation is detrimental for neurogenesis in adult brain

Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968 · see citing works

Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics

Jope, R. S., Yuskaitis, C. J., & Beurel, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9128-5 · Cited by 774 · see citing works

Functional plasticity of macrophages: reversible adaptation to changing microenvironments

Stout, R. D., & Suttles, J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0504272 · Cited by 751 · see citing works

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Cai, Z., Hussain, M. D., & Yan, L.-J. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.833510 · Cited by 583 · see citing works

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

Fattahi, P., Yang, G., Kim, G., & Abidian, M. R. (2014) · Advanced Materials · doi:10.1002/adma.201304496 · Cited by 580 · see citing works

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536 · see citing works

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · see citing works

Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition

Croisier, E., Moran, L. B., Dexter, D. T., Pearce, R. K., & Graeber, M. B. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-14 · Cited by 414 · see citing works

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433 · see citing works

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.014 · Cited by 426 · see citing works

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403 · see citing works

Critical role of TLR4 response in the activation of microglia induced by ethanol

Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works

Early Environmental Origins of Neurodegenerative Disease in Later Life

Landrigan, P. J., Sonawane, B., Butler, R. N., Trasande, L., Callan, R., & Droller, D. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7571 · Cited by 357 · see citing works

Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration

Sankowski, R., Mader, S., & Valdés-Ferrer, S. I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00028 · Cited by 351 · see citing works

Ketogenic Diet in Alzheimer’s Disease

Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163892 · Cited by 319 · see citing works

Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand

Taylor, D. L., Jones, F., Kubota, E. S. F. C. S., & Pocock, J. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-04.2005 · Cited by 308 · see citing works

Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes

Vallés, S. L., Blanco, A. M., Pascual, M., & Guerri, C. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00079.x · Cited by 271 · see citing works

Aβ-degrading enzymes: potential for treatment of Alzheimer disease

Miners, J. S., Barua, N., Kehoe, P. G., Gill, S., & Love, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182345e46 · Cited by 265 · see citing works

The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

Dutta, G., Zhang, P., & Liu, B. (2008) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00616.x · Cited by 235 · see citing works

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

Yuan, L., Liu, S., Bai, X., Gao, Y., Liu, G., Wang, X., Liu, D., Li, T., Hao, A., & Wang, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0541-7 · Cited by 213 · see citing works

Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)

Ho, S.-C., & Kuo, C.-T. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.06.014 · Cited by 211 · see citing works

Minocycline Reduces the Lipopolysaccharide-Induced Inflammatory Reaction, Peroxynitrite-Mediated Nitration of Proteins, Disruption of the Blood–Brain Barrier, and Damage in the Nigral Dopaminergic System

Tomás-Camardiel, M., Rite, I., Herrera, A. J., de Pablos, R. M., Cano, J., Machado, A., & Venero, J. L. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.010 · Cited by 203 · see citing works

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder

Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.007 · Cited by 184 · see citing works

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works

Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants

Hwang, J., Zheng, L. T., Ock, J., Lee, M. G., Kim, S.-H., Lee, H.-W., Lee, W.-H., Park, H.-C., & Suk, K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.045 · Cited by 181 · see citing works

Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia

Sumi, N., Nishioku, T., Takata, F., Matsumoto, J., Watanabe, T., Shuto, H., Yamauchi, A., Dohgu, S., & Kataoka, Y. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9446-7 · Cited by 179 · see citing works

Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations

Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works

Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment

Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173 · see citing works

Polyunsaturated fatty acids, neuroinflammation and well being

Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167 · see citing works

Doxycycline Suppresses Microglial Activation by Inhibiting the P38 MAPK and NF-KB Signaling Pathways

Santa-Cecília, F. V., Socias, B., Ouidja, M. O., Sepulveda-Diaz, J. E., Acuña, L., Silva, R. L., Michel, P. P., Del-Bel, E., Cunha, T. M., & Raisman-Vozari, R. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9592-2 · Cited by 165 · see citing works

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Saba, R., Gushue, S., Huzarewich, R. L. C. H., Manguiat, K., Medina, S., Robertson, C., & Booth, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030832 · Cited by 151 · see citing works

Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration

O'Sullivan, J. B., Ryan, K. M., Curtin, N. M., Harkin, A., & Connor, T. J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570800967x · Cited by 146 · see citing works

Diet, gut microbiota and cognition

Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works

The Role of Neuroinflammation in Dementias

Pasqualetti, G., Brooks, D. J., & Edison, P. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0531-7 · Cited by 133 · see citing works

Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson’s Disease

Patricio, F., Morales-Andrade, A. A., Patricio-Martínez, A., & Limón, I. D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595635 · Cited by 129 · see citing works

Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK

Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works

MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Pei, Z., Pang, H., Qian, L., Yang, S., Wang, T., Zhang, W., Wu, X., Dallas, S., Wilson, B., Reece, J. M., et al. (2007) · Glia · doi:10.1002/glia.20545 · Cited by 105 · see citing works

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

Knezevic, D., & Mizrahi, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.007 · Cited by 97 · see citing works

Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer’s Disease and Parkinson’s Disease Dementia?

Femminella, G. D., Ninan, S., Atkinson, R., Fan, Z., Brooks, D. J., & Edison, P. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150827 · Cited by 88 · see citing works

Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia

Marioni, R. E., Stewart, M. C., Murray, G. D., Deary, I. J., Fowkes, F. G. R., Lowe, G. D. O., Rumley, A., & Price, J. F. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181b1e538 · Cited by 86 · see citing works

Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats

Yang, F., Liu, Z., Chen, J., Zhang, S., Quan, Q., Huang, Y., & Jiang, W. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22224 · Cited by 80 · see citing works

Inflammation and depression: Is there a causal connection with dementia?

E.Leonard, B., & Myint, A. (2006) · Neurotoxicity Research · doi:10.1007/bf03033243 · Cited by 76 · see citing works

Retinal Microglia in Glaucoma

Wang, J.-W., Chen, S.-D., Zhang, X.-L., & Jonas, J. B. (2016) · Journal of Glaucoma · doi:10.1097/ijg.0000000000000200 · Cited by 69 · see citing works

<i>Fosb</i>gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia: <i>Fosb</i>Regulates Expression of C5a Receptors

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J., & Nakabeppu, Y. (2014) · Glia · doi:10.1002/glia.22680 · Cited by 68 · see citing works

Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study

Juncal-Ruiz, M., Riesco-Dávila, L., Ortiz-García de la Foz, V., Martínez-Garcia, O., Ramírez-Bonilla, M., Ocejo-Viñals, J. G., Leza, J. C., López-Hoyos, M., & Crespo-Facorro, B. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.039 · Cited by 55 · see citing works

Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity

McLaughlin, P., Zhou, Y., Ma, T., Liu, J., Zhang, W., Hong, J., Kovacs, M., & Zhang, J. (2006) · Glia · doi:10.1002/glia.20294 · Cited by 55 · see citing works

An Investigation of the Neuroprotective Effects of Tetracycline Derivatives in Experimental Models of Retinal Cell Death

Baptiste, D. C., Hartwick, A. T. E., Jollimore, C. A. B., Baldridge, W. H., Seigel, G. M., & Kelly, M. E. M. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.001081 · Cited by 55 · see citing works

l-Carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture

Wang, C., Sadovova, N., Ali, H. K., Duhart, H. M., Fu, X., Zou, X., Patterson, T. A., Binienda, Z. K., Virmani, A., Paule, M. G., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.083 · Cited by 55 · see citing works

Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures

Gibbons, H. M., Smith, A. M., Teoh, H. H., Bergin, P. M., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.024 · Cited by 49 · see citing works

Effects of Catalpol on Mitochondrial Function and Working Memory in Mice after Lipopolysaccharide-Induced Acute Systemic Inflammation

Zhang, A., Hao, S., Bi, J., Bao, Y., Zhang, X., An, L., & Jiang, B. (2009) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2008.10.010 · Cited by 46 · see citing works

PSMC5 Regulates Microglial Polarization and Activation in LPS-Induced Cognitive Deficits and Motor Impairments by Interacting with TLR4

Bi, W., Bao, K., Zhou, X., Deng, Y., Li, X., Zhang, J., Lan, X., Zhao, J., Lu, D., Xu, Y., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02904-9 · Cited by 36 · see citing works

Kainic Acid-Activated Microglia Mediate Increased Excitability of Rat Hippocampal Neurons in vitro and in vivo: Crucial Role of Interleukin-1beta

Zheng, H., Zhu, W., Zhao, H., Wang, X., Wang, W., & Li, Z. (2010) · Neuroimmunomodulation · doi:10.1159/000243083 · Cited by 39 · see citing works

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

Kaminsky, N., Bihari, O., Kanner, S., & Barzilai, A. (2016) · Genomics, Proteomics &amp; Bioinformatics · doi:10.1016/j.gpb.2016.04.003 · Cited by 38 · see citing works

MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines

Ma, J., Zhao, W., Pei, X., et al. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03797-3 · Cited by 3 · see citing works

Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner

Zhao, J., Hu, Y., Huang, C., et al. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.002 · Cited by 21 · see citing works

Contributions of Microglia in the Healthy and Injured Brain

Rice, R. A. (2015) · eScholarship (California Digital Library)

Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine in vitro

Nakajima, K., Kanamatsu, T., Koshimoto, M., & Kohsaka, S. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.015 · Cited by 7 · see citing works

Effects of Proinflammatory Cytokines in the Heart

Zhang, C. (2004) · Life Science Research