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Stratified medicine for mental disorders
Open accessAbstract
There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological mechanisms underlying mental disorder. The resulting increase in diagnostic precision and targeted treatments may provide a window of opportunity to address the large public health burden, and individual suffering associated with mental disorders. While mental health and mental disorders have significant representation in the "health, demographic change and wellbeing" challenge identified in Horizon 2020, the framework programme for research and innovation of the European Commission (2014-2020), and in national funding agencies, clear advice on a potential strategy for mental health research investment is needed. The development of such a strategy is supported by the EC-funded "Roadmap for Mental Health Research" (ROAMER) which will provide recommendations for a European mental health research strategy integrating the areas of biomedicine, psychology, public health well being, research integration and structuring, and stakeholder participation. Leading experts on biomedical research on mental disorders have provided an assessment of the state of the art in core psychopathological domains, including arousal and stress regulation, affect, cognition social processes, comorbidity and pharmacotherapy. They have identified major advances and promising methods and pointed out gaps to be addressed in order to achieve the promise of a stratified medicine for mental disorders.
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“These objectives are also consistent with the European roadmap for mental health research (3).”
From Understanding heterogeneity in clinical cohorts using normative models: Beyond case-control studies (2016) · cites this paper as [3]
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Metadata
- Authors
- Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., Ciccocioppo, R., Cools, R., Escera, C., Fleischhacker, W., Flor, H., Frith, C. D., Heinz, A., Johnsen, E., Kirschbaum, C., Klingberg, T., Lesch, K.-P., Lewis, S., Maier, W., Mann, K., Martinot, J.-L., Meyer-Lindenberg, A., Müller, C. P., Müller, W. E., Nutt, D. J., Persico, A., Perugi, G., Pessiglione, M., Preuss, U. W., Roiser, J. P., Rossini, P. M., Rybakowski, J. K., Sandi, C., Stephan, K. E., Undurraga, J., Vieta, E., van der Wee, N., Wykes, T., Haro, J. M., & Wittchen, H. U.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Norwegian Institute of Public Health (NO)
- University of Bergen (NO)
- University of Cambridge (GB)
- University of St Andrews (GB)
- Radboud University Nijmegen (NL)
- Università di Camerino (IT)
- Donders Institute for Brain, Cognition and Behaviour (NL)
- Universitat de Barcelona (ES)
- Innsbruck Medical University (AT)
- Heidelberg University (DE)
- Wellcome Centre for Human Neuroimaging (GB)
- Bernstein Center for Computational Neuroscience Berlin (DE)
- Technische Universität Dresden (DE)
- Karolinska Institutet (SE)
- University of Würzburg (DE)
- University of Bonn (DE)
- Central Institute of Mental Health (DE)
- Université Paris-Sud (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Goethe University Frankfurt (DE)
- Imperial College London (GB)
- Università Campus Bio-Medico (IT)
- University of Pisa (IT)
- Pitié-Salpêtrière Hospital (FR)
- Martin Luther University Halle-Wittenberg (DE)
- University College London (GB)
- Università Cattolica del Sacro Cuore (IT)
- Poznan University of Medical Sciences (PL)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Zurich (CH)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- King's College London (GB)
- ORCID
- Binder, Elisabeth B.
- Holte, Arne
- Oedegaard, Ketil J.
- Robbins, Trevor W.
- Brown, Verity J.
- Buitelaar, Jan
- Ciccocioppo, Roberto
- Cools, Roshan
- Escera, Carles
- Flor, Herta
- Frith, Chris D.
- Heinz, Andreas
- Johnsen, Erik
- Kirschbaum, Clemens
- Klingberg, Torkel
- Lesch, Klaus-Peter
- Mann, Karl
- Martinot, Jean-Luc
- Müller, Christian P.
- Nutt, David J.
- Persico, Antonio
- Perugi, Giulio
- Pessiglione, Mathias
- Preuss, Ulrich W.
- Roiser, Jonathan P.
- Rossini, Paolo M.
- Rybakowski, Janusz K.
- Sandi, Carmen
- Stephan, Klaas E.
- Undurraga, Juan
- Vieta, Eduard
- Wykes, Til
- Haro, Josep Maria
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 24
- Issue
- 1
- Pages
- 5-50
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2130081193
- Cited by
- 186
- References
- 287
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 3 · 2022: 11 · 2021: 8 · 2020: 21 · 2019: 19 · 2018: 11 · 2017: 17 · 2016: 20 · 2015: 26 · 2014: 12
- FWCI
- 57.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Neuropsychopharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc-nd)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by-nc-nd)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Unicam Scientific Publications (University of Camerino) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, other-oa)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Funders
- European Commission's Seventh Framework Programme Project ROAMER (FP7-HEALTH-2011/No. 282586)
- NIHR Biomedical Research Centre
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Interdisciplinary Research and Collaboration
- Keywords
- stratified medicine, mental illness, psychopathology, affect, cognition, social processes, comorbidities, pharmacotherapy, research funding
- MeSH terms
- Mental Disorders, Brain, Europe, Humans, Biomedical Research, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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