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Cited by 112Schizophrenia research and treatmentMedication Adherence and CompliancePsychotherapy Techniques and Applications

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Treatment adherence in schizophrenia: A patient-level meta-analysis of combined CATIE and EUFEST studies

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Czobor, Pál, Van Dorn, Richard A., Citrome, Leslie, Kahn, Rene S., Fleischhacker, W. Wolfgang, Volavka, Jan·2015·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2015.04.003PMC PMC4860611
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Abstract

The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) obtained a sample of 1493 chronic schizophrenia patients. The European First Episode Schizophrenia Trial (EUFEST) studied a sample of 498 patients. We have combined these two samples to study the predictors and correlates of adherence to treatment. Here we report on adherence to pharmacological treatment at the six and twelve month assessments of these trials with a combined subsample of 1154 schizophrenia patients. Individual patients׳ data were used for analyses. We used logistic regression to examine the effects of substance use, akathisia, parkinsonism, dyskinesia, hostility, and insight on pharmacological adherence. The results showed that reduced adherence to pharmacological treatment was associated with substance use (p=0.0003), higher levels of hostility (p=0.0002), and impaired insight (p<0.0001). Furthermore, poor adherence to study medication was associated with earlier discontinuation in the combined data. The clinical implications of the results point to the importance of routine assessments and interventions to address patients׳ insight and comorbid substance use and the establishment of therapeutic alliance.

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  1. Velligan, 2009, The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness, J. Clin. Psychiatry, 70, S1

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Metadata

Authors
Czobor, P., Van Dorn, R. A., Citrome, L., Kahn, R. S., Fleischhacker, W. W., & Volavka, J.
Affiliations
  • Semmelweis University (HU)
  • New York Medical College (US)
  • Innsbruck Medical University (AT)
  • New York University (US)
Corresponding author
Czobor, Pál
ORCID
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2015-08
Volume
25
Issue
8
Pages
1158-1166
ISSN
0924-977X (ISSN-L)
DOI
10.1016/j.euroneuro.2015.04.003
PMC
PMC4860611
OpenAlex
W2125320544
Cited by
112
References
49
Citations by year
2026: 7 · 2025: 9 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 16 · 2020: 16 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 3
FWCI
1.61
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Semmelweis University Repository (Semmelweis University) (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
  • Bristol-Myers Squibb
  • National Institute of Mental Health (R01MH093426)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
medication adherence, schizophrenia, antipsychotic drugs, substance use, hostility, insight, akathisia, parkinsonism, dyskinesia, drug discontinuation, therapeutic relationship, predictors of adherence
MeSH terms
Assessment of Medication Adherence, Humans, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Randomized Controlled Trials as Topic, Drug Monitoring, Medication Adherence

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