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Cited by 29Pain Mechanisms and TreatmentsPain Management and TreatmentNerve injury and regeneration

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Respective pharmacological features of neuropathic-like pain evoked by intrathecal BDNF versus sciatic nerve ligation in rats

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M’Dahoma, Saïd, Barthélemy, Sandrine, Tromilin, Claire, Jeanson, Tiffany, Viguier, Florent, Michot, Benoit, Pezet, Sophie, Hamon, Michel, Bourgoin, Sylvie·2015·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2015.07.026
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Abstract

Numerous reported data support the idea that Brain Derived Neurotrophic Factor (BDNF) is critically involved in both depression and comorbid pain. The possible direct effect of BDNF on pain mechanisms was assessed here and compared with behavioral/neurobiological features of neuropathic pain caused by chronic constriction injury to the sciatic nerve (CCI-SN). Sprague-Dawley male rats were either injected intrathecally with BDNF (3.0 ng i.t.) or subjected to unilateral CCI-SN. Their respective responses to anti-hyperalgesic drugs were assessed using the Randall-Selitto test and both immunohistochemical and RT-qPCR approaches were used to investigate molecular/cellular mechanisms underlying hyperalgesia in both models. Long lasting hyperalgesia and allodynia were induced by i.t. BDNF in intact healthy rats like those found after CCI-SN. Acute treatment with the BDNF-TrkB receptor antagonist cyclotraxin B completely prevented i.t. BDNF-induced hyperalgesia and partially reversed this symptom in both BDNF-pretreated and CCI-SN lesioned rats. Acute administration of the anticonvulsant pregabalin, the NMDA receptor antagonist ketamine, the opioid analgesics morphine and tapentadol or the antidepressant agomelatine also transiently reversed hyperalgesia in both i.t. BDNF injected- and CCI-SN lesioned-rats. Marked induction of microglia activation markers (OX42, Iba1, P-p38), proinflammatory cytokine IL-6, NMDA receptor subunit NR2B and BDNF was found in spinal cord and/or dorsal roo…

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Metadata

Authors
M’Dahoma, S., Barthélemy, S., Tromilin, C., Jeanson, T., Viguier, F., Michot, B., Pezet, S., Hamon, M., & Bourgoin, S.
Affiliations
  • Inserm (FR)
  • Theranexus (France) (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Bourgoin, Sylvie
ORCID
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2015-11
Volume
25
Issue
11
Pages
2118-2130
ISSN
0924-977X (ISSN-L)
DOI
10.1016/j.euroneuro.2015.07.026
OpenAlex
W1171845611
Cited by
29
References
3
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 4
FWCI
3.12
Type
journal article
Language
en
Open access
Licence
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • (Grünenthal, Servier)
  • Tevrasamy Marday
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
brain-derived neurotrophic factor, neuropathic pain, chronic constriction injury, sciatic nerve ligation, TrkB receptor, hyperalgesia, allodynia, pregabalin, ketamine, morphine, tapentadol, agomelatine, microglial activation, interleukin-6, NMDA receptor NR2B, spinal cord, dorsal root ganglia
MeSH terms
Analgesics, Animals, Disease Models, Animal, Ganglia, Spinal, Hyperalgesia, Injections, Spinal, Ligation, Male, Neuralgia, Neuroglia, Sciatic Nerve, Spinal Cord, Touch, Neuroimmunomodulation, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor

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