Bereitschaftspotential and lateralized readiness potential in children with attention deficit hyperactivity disorder: altered motor system activation and effects of methylphenidate
Abstract
Attention deficit hyperactivity disorder (ADHD) has been linked to abnormal functioning of cortical motor areas such as the supplementary motor area, the premotor cortex and primary motor cortex (MI). The Bereitschaftspotential (BP) and lateralized readiness potential (LRP) are movement-related potentials generated by cortical motor areas. We hypothesized that the BP and LRP would be altered in children with ADHD. A group of 17 children with ADHD (mean age: 11.5 ± 1.9 years) and a control group of 16 typically developing children (mean age: 12.2 ± 2.0 years) performed movements at self-chosen irregular intervals while a 64-channel DC-EEG was registered. BP and LRP were calculated from the EEG. The ADHD group had significantly lower and on average positive BP amplitudes at Cz. In agreement with age-dependent maturation effects the LRP had a positive polarity in both groups, but lower amplitudes were found in the ADHD group without medication. The control group showed a mid-central negativity and a positivity over motor areas contra-lateral to the side of movement, whereas no negativity over Cz and a more diffuse positivity was found in the ADHD group. LRP group differences diminished after MPH administration as indicated by an interaction between group and time of measurement/medication. The cortical motor system shows altered functioning during movement preparation and initiation in children affected by ADHD. Positive Bereitschaftspotential polarities may represent delayed co…
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Functional hypoactivation and volumetric reduction of the SMA constitute the psychopathological model of ADHD underlying excessively impulsive actions.
“Functional hypoactivation and volumetric reduction of the SMA constitute the psychopathological model of ADHD underlying excessively impulsive actions”
From Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: A comparative neuroimaging analysis (2024) · cites this paper as Jarczok, Haase, Bluschke, Thiemann, & Bender, 2019
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Pan, N., Ma, T., Liu, Y., Zhang, S., Hu, S., Shekara, A., Cao, H., Gong, Q., & Chen, Y. (2024) · Psychological Medicine · doi:10.1017/s003329172400285x · Cited by 7 · see citing works
- Authors
- Jarczok, T. A., Haase, R., Bluschke, A., Thiemann, U., & Bender, S.
- Affiliations
- University of Cologne (DE)
- Technische Universität Dresden (DE)
- Corresponding author
- Jarczok, Tomasz A.
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 29
- Issue
- 8
- Pages
- 960-970
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2954489386
- Cited by
- 18
- References
- 9
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, readiness potential, lateralized readiness potential, motor preparation, methylphenidate, cortical maturation, children, supplementary motor area, premotor cortex, primary motor cortex
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Child, Contingent Negative Variation, Cross-Sectional Studies, Electroencephalography, Electromyography, Female, Humans, Male, Methylphenidate, Motor Activity
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