SGK1 knockdown in the medial prefrontal cortex reduces resistance to stress-induced memory impairment
Abstract
Down-regulation of serum and glucocorticoid-regulated kinase1 (SGK1) expression has been reported in the postmortem prefrontal cortex (PFC) of subjects with post-traumatic stress disorder. Furthermore, experimental treatments that reduce SGK1 function in the medial prefrontal cortex (mPFC) cause depressive-like behaviors and synaptic dysfunction. Therefore, we examined the effect of SGK1 down-regulation in the mPFC on resistance to stress-induced cognitive impairment. Rats with viral-mediated knockdown of SGK1 in the mPFC were subjected to either a brief 20-min restraint plus 20 intermittent tail shocks or a prolonged 60-min restraint plus 60 intermittent tail shocks, after which their performance in an object recognition task was assessed. Recognition memory remained intact in control rats following the brief stress, but was impaired in rats with SGK1 knockdown in the mPFC. Prolonged stress impaired recognition memory in both control rats and rats with SGK1 knockdown. Our findings indicate that altered mPFC SGK1 signaling is a potential mechanism for resistance to stress-induced cognitive impairment.
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In rats, inhibiting SGK1 expression in the medial prefrontal cortex leads to impaired recognition memory under stress conditions.
“In rats, inhibiting expression of SGK1 in the medial prefrontal cortex (mPFC) leads to impaired recognition memory under stress conditions”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Park et al., 2021
Cites
Failure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · see citing works
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960 · see citing works
The functional neuroanatomy of PTSD: a critical review
Liberzon, I., & Sripada, C. S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67011-3 · Cited by 594 · see citing works
Kim, J. J., Koo, J. W., Lee, H. J., & Han, J.-S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-04.2005 · Cited by 184 · see citing works
Self-citationAmat, J., Paul, E., Watkins, L. R., & Maier, S. F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.005 · Cited by 153 · see citing works
Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress
Lee, S.-Y., Park, S.-H., Chung, C., Kim, J. J., Choi, S.-Y., & Han, J.-S. (2015) · Scientific Reports · doi:10.1038/srep18540 · Cited by 119 · see citing works
Self-citationLicznerski, P., Duric, V., Banasr, M., Alavian, K. N., Ota, K. T., Kang, H. J., Jonas, E. A., Ursano, R., Krystal, J. H., Duman, R. S., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002282 · Cited by 79 · see citing works
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Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works
Liu, M., Lian, B., Lan, Z., Sun, H., Zhao, Y., Sun, T., Meng, Z., Zhao, C., & Zhang, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03690-1 · Cited by 8 · see citing works
- Authors
- Park, J.-C., Jeon, Y.-J., Jang, Y.-S., Cho, J., Choi, D.-H., & Han, J.-S.
- Affiliations
- Konkuk University (KR)
- Ewha Womans University (KR)
- Corresponding author
- Choi, Dong-Hee
- Han, Jung-Soo
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 45
- Pages
- 29-34
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W3138250529
- Cited by
- 12
- References
- 7
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- SGK1, medial prefrontal cortex, stress-induced memory impairment, recognition memory, chronic restraint stress, post-traumatic stress disorder, synaptic dysfunction
- MeSH terms
- Animals, Memory Disorders, Restraint, Physical, Stress Disorders, Post-Traumatic, Prefrontal Cortex, Recognition, Psychology, Rats
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