Cited by 594Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsMemory Processes and Influences

The functional neuroanatomy of PTSD: a critical review

Liberzon, Israel, Sripada, Chandra Sekhar·2007·Progress in Brain Research

Abstract

Neuroimaging provides an opportunity to understand core processes that mediate the experience of emotions in healthy individuals as well as dysregulation of these processes in conditions such as posttraumatic stress disorder (PTSD). The first decade of neuroimaging research produced symptom provocation, cognitive activation, and functional connectivity studies that highlighted the role of the medial prefrontal cortex (mPFC), amygdala, sublenticular extended amygdala (SLEA), and hippocampus, in mediating symptom formation in PTSD. There is a growing realization that a number of other psychological processes are relevant to PTSD, and they are emerging as a new focus of neuroimaging research. These include fear conditioning, habituation, and extinction; cognitive-emotional interactions; and self-related and social emotional processing. Neuroimaging findings are reviewed that suggest that the mPFC is implicated in a number of these processes. It is proposed that the mPFC plays a role in the "contextualization" of stimuli, and dysregulation of contextualization processes might play a key role in the generation of PTSD symptoms.

Integrity signals

Registry

Crossref · 10.1016/s0079-6123(07)67011-3

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Liberzon, I., & Sripada, C. S.
Affiliations
University of Michigan (US)
Corresponding author
Liberzon, Israel
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2007
Volume
167
Pages
151-169
ISSN
0079-6123 (ISSN-L)
OpenAlex
W1564331199
Cited by
594
References
71
Citations by year
2026: 11 · 2025: 17 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 33 · 2020: 45 · 2019: 24 · 2018: 42 · 2017: 37 · 2016: 46 · 2015: 37 · 2014: 46 · 2013: 42 · 2012: 43
FWCI
91.41
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
post-traumatic stress disorder, functional neuroanatomy, medial prefrontal cortex, amygdala, hippocampus, fear conditioning, habituation, extinction, cognitive-emotional interaction, social-emotional processing, contextualization, emotional dysregulation
MeSH terms
Animals, Cognition, Humans, Magnetic Resonance Imaging, Stress Disorders, Post-Traumatic, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review