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Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area

Sherpa, Nima Norbu, De Giorgi, Riccardo, Ostinelli, Edoardo Giuseppe, Choudhury, Amrita, Dolma, Tenzin, Dorjee, Sangila·2025·European Neuropsychopharmacology

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Crossref · 10.1016/j.euroneuro.2024.10.004

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Research works printed but not linked: 27

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  2. Allen, 2012, Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats, Pharmacol., Biochem. Behav., 101, 588, 10.1016/j.pbb.2012.03.005 · DOI
  3. Allen, 2015, Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats, Pharmacol., Biochem. Behav., 130, 22, 10.1016/j.pbb.2014.12.014 · DOI
  4. Buerkner, 2017, Brms: an R package for bayesian multilevel models using stan, J. Stat. Softw., 80, 1
  5. Candow, 2023, Heads up” for creatine supplementation and its potential applications for brain health and function, Sports Med. (Auckland), 1
  6. Chevance, 2022, Important adverse events to be evaluated in antidepressant trials and meta-analyses in depression: a large international preference study including patients and healthcare professionals, Evid. Based Ment. Health, 25, e41, 10.1136/ebmental-2021-300418 · DOI
  7. Croatto, 2023, The impact of pharmacological and non-pharmacological interventions on physical health outcomes in people with mood disorders across the lifespan: an umbrella review of the evidence from randomised controlled trials, Mol. Psychiatry, 28, 369, 10.1038/s41380-022-01770-w · DOI · Paper page
  8. Cunha, 2012, Antidepressant-like effect of creatine in mice involves dopaminergic activation, J. Psychopharmacol. (Oxford), 26, 1489, 10.1177/0269881112447989 · DOI
  9. Cunha, 2013, Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice, Brain Res. Bull., 95, 61, 10.1016/j.brainresbull.2013.01.005 · DOI
  10. Faulkner, 2021, Relationship between depression, prefrontal creatine and grey matter volume, J. Psychopharmacol. (Oxford), 35, 1464, 10.1177/02698811211050550 · DOI
  11. Forbes, 2022, Effects of creatine supplementation on brain function and health, Nutrients, 14, 921, 10.3390/nu14050921 · DOI · Paper page
  12. Ghaemian, 2020, Therapy discontinuation in a primary care psychological service: why patients drop out, Cognit. Behav. Therap., 13, e25, 10.1017/S1754470X20000240 · DOI · Paper page
  13. Kanekar, 2021, Sex-based impact of creatine supplementation on depressive symptoms, brain serotonin and SSRI efficacy in an animal model of treatment-resistant depression, Int. J. Mol. Sci., 22, 8195, 10.3390/ijms22158195 · DOI
  14. Kious, 2017, An open-label pilot study of combined augmentation with creatine monohydrate and 5-hydroxytryptophan for selective serotonin reuptake inhibitor- or serotonin-norepinephrine reuptake inhibitor-resistant depression in adult women, J. Clin. Psychopharmacol., 37, 578, 10.1097/JCP.0000000000000754 · DOI · Paper page
  15. Kondo, 2011, Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study, J Affect Disord, 135, 354, 10.1016/j.jad.2011.07.010 · DOI · Paper page
  16. Kondo, 2016, Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression, Amino Acids, 48, 1941, 10.1007/s00726-016-2194-3 · DOI · Paper page
  17. Lyoo, 2003, Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate, Psychiatry Res., 123, 87, 10.1016/S0925-4927(03)00046-5 · DOI · Paper page
  18. Lyoo, 2012, A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder, Am. J. Psychiatry, 169, 937, 10.1176/appi.ajp.2012.12010009 · DOI · Paper page
  19. Nemets, 2013, A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depression, Int. Clin. Psychopharmacol., 28, 127, 10.1097/YIC.0b013e32835ff20f · DOI
  20. Pazini, 2019, The possible beneficial effects of creatine for the management of depression, Prog. Neuropsychopharmacol. Biol. Psychiatry, 89, 193, 10.1016/j.pnpbp.2018.08.029 · DOI
  21. Pazini, 2020, mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test, Chem. Biol. Interact., 332, 10.1016/j.cbi.2020.109281 · DOI
  22. Raman, 2021, Impact on health and provision of healthcare services during the COVID-19 lockdown in india: a multicentre cross-sectional study, BMJ Open, 11, 10.1136/bmjopen-2020-043590 · DOI
  23. Toniolo, 2018, A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression, J. Neural Transm., 125, 247, 10.1007/s00702-017-1817-5 · DOI · Paper page
  24. van Buuren, 2011, Mice: multivariate imputation by chained equations in R, J Stat Softw, 45, 1
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  26. Yoon, 2016, Effects of creatine monohydrate augmentation on brain metabolic and network outcome measures in women with major depressive disorder, Biol. Psychiatry., 80, 439, 10.1016/j.biopsych.2015.11.027 · DOI · Paper page
  27. Yuan, 2022, Neural effects of cognitive behavioral therapy in psychiatric disorders: a systematic review and activation likelihood estimation meta-analysis, Front. Psychol.

Cited by

Metadata

Authors
Sherpa, N. N., De Giorgi, R., Ostinelli, E. G., Choudhury, A., Dolma, T., & Dorjee, S.
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2025-01
Volume
90
Pages
28-35
ISSN
0924-977X
Cited by
22
References
21
Language
en
Licence

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