Predictability of a favorable outcome in anorexia nervosa
Abstract
Objective: In a long-term follow-up of anorexia nervosa (AN) patients, somatic, psychological and social variables at clinical presentation should be investigated using a multilevel approach. Methods: This study isolated predictors known from the literature over longer time periods and carried out a separate investigation of predictors in a sample of 81 AN patients of the Heidelberg–Mannheim study over a mean period of 12 years (range 9–19 years). Separate hierarchic regression analyses on the basis of the course of the Morgan–Russell categories were calculated for four individually recorded areas: anamnestic, psychological, somatic and social data sets. Results: Age at the onset of the disease, purging behavior, low serum albumin, high glutamic-oxalo acetic transaminase (GOT) psychopathology (ANSS) and social pathology had the highest predictive value qualities. In survival analysis overall assessment of all six main predictors at clinical presentation could differentiate all patients who recovered from those who remained ill (log-rank test P = 0.019). Conclusions: A small number of variables were important for detecting a good or poor long-term course of AN. At onset of the disease, it seems necessary to evaluate these psychological, somatic and social predictors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Cooper, A. M., & Michels, R. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.1.128 · Cited by 7,417 · see citing works
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491 · see citing works
Clinical Trials: A Practical Approach.
Hill, I. D., & Pocock, S. (1984) · Biometrics · doi:10.2307/2531186 · Cited by 2,918 · see citing works
Gómez, J. G., & Dally, P. (1979) · Cited by 1,965 · see citing works
Morgan, H. G., & RUSSELL, G. F. M. (1975) · Psychological Medicine · doi:10.1017/s0033291700056981 · Cited by 776 · see citing works
Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study
Zipfel, S., Löwe, B., Reas, D. L., Deter, H.-C., & Herzog, W. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05363-5 · Cited by 524 · see citing works
Self-citationComorbidity of Psychiatric Diagnoses in Anorexia Nervosa
Halmi, K. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320036006 · Cited by 509 · see citing works
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-5-776_4 · Cited by 397 · see citing works
Predictors of Mortality in Eating Disorders
Keel, P. K., Dorer, D. J., Eddy, K. T., Franko, D. L., Charatan, D. L., & Herzog, D. B. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.179 · Cited by 388 · see citing works
Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study
LÖWE, B., ZIPFEL, S., BUCHHOLZ, C., DUPONT, Y., REAS, D. L., & HERZOG, W. (2001) · Psychological Medicine · doi:10.1017/s003329170100407x · Cited by 373 · see citing works
Self-citationAnorexia nervosa: outcome and prognostic factors after 20 years
Ratnasuriya, R. H., Eisler, I., Szmukler, G. I., & Russell, G. F. M. (1991) · British Journal of Psychiatry · doi:10.1192/bjp.158.4.495 · Cited by 369 · see citing works
Theander, S. S. (1985) · Journal of Psychiatric Research · doi:10.1016/0022-3956(85)90059-7 · Cited by 339 · see citing works
Lucas, A. R. (1984) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62433-1 · Cited by 310 · see citing works
Clinical Assessment of Anorexia Nervosa
Morgan, H. G., & Hayward, A. (1988) · The British Journal of Psychiatry · doi:10.1192/bjp.152.3.367 · Cited by 280 · see citing works
Outcome in patients with eating disorders: a 5-year study
Ben-Tovim, D. I., Walker, K., Gilchrist, P. N., Freeman, R. K., Kalucy, R., & Esterman, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04406-8 · Cited by 262 · see citing works
Lehrbuch der psychosomatischen Medizin
von Uexküll, T., & Adler, R. H. (1979) · Urban & Schwarzenberg eBooks · Cited by 219 · see citing works
Follow-up studies of anorexia nervosa: a review of four decades of outcome research
Steinhausen, H. ‐., Rauss-Mason, C., & Seidel, R. (1991) · Psychological Medicine · doi:10.1017/s0033291700020559 · Cited by 211 · see citing works
Herzog, W., Deter, H., Fiehn, W., & Petzold, E. R. (1997) · Psychological Medicine · doi:10.1017/s0033291796004394 · Cited by 207 · see citing works
Self-citationOutcome of bone mineral density in anorexia nervosa patients 11.7 years after first admission
Herzog, W., Minne, H. W., Deter, H., Leidig, G., Schellberg, D., Wüster, C. C., Gronwald, R. G., Sarembe, E., Kröger, F., Bergmann, G., et al. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080511 · Cited by 191 · see citing works
Self-citationAnorexia nervosa in a long‐term perspective: results of the Heidelberg‐Mannheim Study.
Deter, H., & Herzog, W. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199401000-00003 · Cited by 187 · see citing works
Self-citationPatton, G. (1988) · Psychological Medicine · doi:10.1017/s0033291700009879 · Cited by 186 · see citing works
Beumont, P. J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90769-d · Cited by 167 · see citing works
Outcome in Anorexia Nervosa and Bulimia Nervosa
Herzog, D. B., Keller, M. B., & Lavori, P. W. (1988) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198803000-00001 · Cited by 142 · see citing works
Long‐term outcome of 151 cases of anorexia nervosa
Tolstrup, K., Brinch, M., Isager, T., Nielsen, S. L., Nystrup, J., Severin, B., & Olesen, N. S. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb02537.x · Cited by 88 · see citing works
Twin studies and the etiology of eating disorders
Fairburn, C. G., Cowen, P. J., & Harrison, P. J. (1999) · International Journal of Eating Disorders · doi:10.1002/(sici)1098-108x(199912)26:4 · Cited by 86 · see citing works
Anorexia Nervosa: Long-term Outcome in 50 Female Patients
Hall, A. K., Slim, E., Hawker, F., & Salmond, C. E. (1984) · The British Journal of Psychiatry · doi:10.1192/bjp.145.4.407 · Cited by 84 · see citing works
Tanaka, H., Kiriike, N., Nagata, T., & Riku, K. (2001) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2001.00880.x · Cited by 44 · see citing works
The Course of Eating Disorders: Long-Term Follow-Up Studies of Anorexia and Bulimia Nervosa
Yates, W. R. (1993) · Psychosomatics · doi:10.1016/s0033-3182(93)71915-5 · Cited by 44 · see citing works
Long-Term Course of Anorexia Nervosa: A Review of the Literature
Herzog, W., Rathner, G., & Vandereycken, W. (1992) · Springer eBooks · doi:10.1007/978-3-642-76634-3_2 · Cited by 38 · see citing works
Self-citationThe Course of Eating Disorders: Long-Term Follow-up Studies of Anorexia and Bulimia Nervosa
Herzog, W., Deter, H., & Vandereycken, W. (2011) · Medical Entomology and Zoology · Cited by 37 · see citing works
Self-citationThe predictability of relapses in schizophrenic patients
Buchkremer, G., Stricker, K., Holle, R., & Kuhs, H. (1991) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02189543 · Cited by 35 · see citing works
Chronicity in Anorexia Nervosa: Results from the Swedish Long-Term Study
Theander, S. S. (1992) · Springer eBooks · doi:10.1007/978-3-642-76634-3_15 · Cited by 28 · see citing works
Child and adolescent predictors for eating disorders in a community population of young adult women
Moorhead, D. J., Stashwick, C. K., Reinherz, H. Z., Giaconia, R. M., Streigel‐Moore, R. M., & Paradis, A. D. (2002) · International Journal of Eating Disorders · doi:10.1002/eat.10105 · Cited by 27 · see citing works
Familienkonfrontationstherapie Bei Anorexia Nervosa
Guntern, G. (1981) · International Journal of Group Psychotherapy · doi:10.1080/00207284.1981.11491718 · Cited by 23 · see citing works
The treatment of anorexia nervosa: do different treatments have different outcomes?
Agras, W. S., & Kraemer, H. C. (1984) · PubMed · Cited by 12 · see citing works
Deter, H. (1992) · Springer eBooks · doi:10.1007/978-3-642-76634-3_4 · Cited by 9 · see citing works
Self-citationRussell, J. D., Abraham, S. F., Zipfel, S., & Herzog, W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06056-1 · Cited by 9 · see citing works
Self-citationBen-Tovim, D. I., & Esterman, A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06057-3 · Cited by 3 · see citing works
Strober (1997) · doi:10.1002/(sici)1098-108x(199712)22:4
Flagged first, then by citations
Cited by
Sorted by citations
Arcelus, J., Mitchell, A. J., Wales, J., & Nielsen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.74 · Cited by 2,864 · see citing works
Outcomes of eating disorders: a systematic review of the literature
Berkman, N. D., Lohr, K. N., & Bulik, C. M. (2007) · International Journal of Eating Disorders · doi:10.1002/eat.20369 · Cited by 595 · see citing works
Factors associated with recovery from anorexia nervosa
Zerwas, S., Lund, B. C., Von Holle, A., Thornton, L. M., Berrettini, W. H., Brandt, H., Crawford, S., Fichter, M. M., Halmi, K. A., Johnson, C., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.011 · Cited by 111 · see citing works
Outcome in AN adult patients: A 13-year follow-up in 484 patients
Rigaud, D., Pennacchio, H., Bizeul, C., Reveillard, V., & Vergès, B. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.11.020 · Cited by 98 · see citing works
- Authors
- Deter, H., Schellberg, D., Köpp, W., Friederich, H., & Herzog, W.
- Affiliations
- University Hospital Heidelberg (DE)
- Freie Universität Berlin (DE)
- ORCID
- Herzog, W.
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-03
- Volume
- 20
- Issue
- 2
- Pages
- 165-172
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- OpenAlex
- W2036841631
- Cited by
- 41
- References
- 39
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2014: 1 · 2013: 5 · 2012: 6
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- anorexia nervosa, long-term outcome prediction, prognostic factors, age of onset, purging behavior, serum albumin, aspartate aminotransferase, psychopathology, social pathology, recovery
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Albumins, Anorexia Nervosa, Aspartate Aminotransferases, Mental Disorders, Child, Female, Follow-Up Studies, Health Status, Humans, Male, Prospective Studies, Regression Analysis, Retrospective Studies, Social Behavior, Survival Analysis, Treatment Outcome, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review