Cited by 84Prostate Cancer Diagnosis and TreatmentSexual function and dysfunction studiesUrinary Bladder and Prostate Research

Ten-year outcomes of sexual function after radical prostatectomy: results of a prospective longitudinal study

Sivarajan, Ganesh, Prabhu, Vinay, Taksler, Glen B., Laze, Juliana, Lepor, Herbert·2014·European Urology

Abstract

Background The long-term impact of radical prostatectomy (RP) on sexual function (SF) and erectile function (EF) has important implications related to the risk-to-benefit ratio of this treatment.Objective To determine the long-term effect of RP on male SF and EF over 10 yr of follow-up.Design, setting, and participants This was a prospective, longitudinal outcomes study in 1836 men following RP at a university hospital. Men were invited to complete the University of California, Los Angeles, Prostate Cancer Index SF survey at baseline, 3, 6, 12, 24, 96, and 120 mo postoperatively and a survey at 4 and 7 yr postoperatively assessing global changes in their EF over the preceding 2 yr.Intervention All men underwent open RP.Outcome measurements and statistical analysis Multiple, generalized linear regression models were used to evaluate the association between time following RP and SF and EF scores controlling for age, prostate-specific antigen, Gleason scores, stage, nerve sparing, race, and marital status.Results and limitations After an expected initial decline, time-dependent improvements in SF and EF were observed through 2 yr postoperatively. Overall, SF and EF were both generally stable between 2 and 10 yr following RP. The subgroups of younger men and men with better preoperative function were more likely to maintain their EF and SF through 10 yr following RP. The primary limitation is the potential bias attributable to nonresponders.Conclusions The recovery of EF can extend well beyond 2 yr. There is a significant association between younger age and better preoperative function and the likelihood of experiencing improvements beyond 2 yr. Assessing the comparative effectiveness of treatment options for localized prostate cancer must examine SF beyond 2 yr to account for delayed treatment effects and the natural history of SF in the aging male population.

Integrity signals

Registry

Crossref · 10.1016/j.eururo.2013.08.019

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sivarajan, G., Prabhu, V., Taksler, G. B., Laze, J., & Lepor, H.
Affiliations
New York University (US)
Corresponding author
Lepor, Herbert
Venue
European Urology
Publisher
Elsevier BV
Published
2014-01
Volume
65
Issue
1
Pages
58-65
ISSN
0302-2838 (ISSN-L)
OpenAlex
W2115725214
Cited by
84
References
30
Citations by year
2026: 4 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 12 · 2016: 7 · 2015: 16 · 2014: 9 · 2013: 6
FWCI
10.30
Type
journal article
Language
en
Open access
closed
Locations
  • European Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
radical prostatectomy, erectile function, sexual function, prostate cancer, long-term outcomes, nerve-sparing surgery, age, preoperative function, UCLA Prostate Cancer Index, delayed recovery
MeSH terms
Adult, Aged, Humans, Longitudinal Studies, Male, Middle Aged, Penile Erection, Prospective Studies, Prostatectomy, Prostatic Neoplasms, Time Factors, Treatment Outcome, Sexuality

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review