Understanding and improving recruitment to randomised controlled trials: qualitative research approaches

Elliott, Daisy; Husbands, Samantha; Hamdy, Freddie C.; Holmberg, Lars; Donovan, Jenny L.

doi:10.1016/j.eururo.2017.04.036

Cited by 161Ethics in Clinical ResearchHealth Policy Implementation ScienceStatistical Methods in Clinical Trials

Understanding and improving recruitment to randomised controlled trials: qualitative research approaches

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Elliott, Daisy, Husbands, Samantha, Hamdy, Freddie C., Holmberg, Lars, Donovan, Jenny L.·2017·European Urology

DOI 10.1016/j.eururo.2017.04.036

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Abstract

CONTEXT: The importance of evidence from randomised trials is now widely recognised, although recruitment is often difficult. Qualitative research has shown promise in identifying the key barriers to recruitment, and interventions have been developed to reduce organisational difficulties and support clinicians undertaking recruitment. OBJECTIVE: This article provides an introduction to qualitative research techniques and explains how this approach can be used to understand-and subsequently improve-recruitment and informed consent within a range of clinical trials. EVIDENCE ACQUISITION: A literature search was performed using Medline, Embase, and CINAHL. All studies with qualitative research methods that focused on the recruitment activity of clinicians were included in the review. EVIDENCE SYNTHESIS: The majority of studies reported that organisational difficulties and lack of time for clinical staff were key barriers to recruitment. However, a synthesis of qualitative studies highlighted the intellectual and emotional challenges that arise when combining research with clinical roles, particularly in relation to equipoise and patient eligibility. To support recruiters to become more comfortable with the design and principles of randomised controlled trials, interventions have been developed, including the QuinteT Recruitment Intervention, which comprises in-depth investigation of recruitment obstacles in real time, followed by implementation of tailored strategies to address these challenges as the trial proceeds. CONCLUSIONS: Qualitative research can provide important insights into the complexities of recruitment to trials and inform the development of interventions, and provide support and training initiatives as required. Investigators should consider implementing such methods in trials expected to be challenging or recruiting below target. PATIENT SUMMARY: Qualitative research is a term used to describe a range of methods that can be implemented to understand participants' perspectives and behaviours. Data are gathered from interviews, focus groups, or observations. In this review, we demonstrate how this approach can be used to understand-and improve-recruitment to clinical trials. Taken together, our review suggests that healthcare professionals can find recruiting to trials challenging and require support with this process.

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Intellectual and emotional challenges arise when combining research with clinical roles, subsequently affecting recruitment.
“Moreover, intellectual and emotional challenges arise when combining research with clinical roles, subsequently affecting recruitment, as has also been previously reported (56).”
From Total Sleep Deprivation Followed by Bright Light Therapy as Rapid Relief for Depression: A Pragmatic Randomized Controlled Trial (2021) · cites this paper as [56]
The 2 treatment arms will be in true clinical equipoise.
“Participants are often concerned about being randomized to a less effective treatment [141, 142], but here the 2 treatment arms will be in true clinical equipoise [143].”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [143]

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Hanrahan, V., Gillies, K., & Biesty, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234783 · Cited by 39 · see citing works
Towards the Development of Sustainable Tourism in Pakistan: A Study of the Role of Tour Operators
Ullah, Z., Naveed, R. T., Rehman, A. U., Ahmad, N., Scholz, M., Adnan, M., & Han, H. (2021) · Sustainability · doi:10.3390/su13094902 · Cited by 40 · see citing works
Recruiting in intervention studies: challenges and solutions
Axén, I., Brämberg, E. B., Bakken, A. G., & Kwak, L. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-044702 · Cited by 41 · see citing works
Exploring qualitative methods reported in registered trials and their yields (EQUITY): systematic review
Clement, C., Edwards, S., Rapport, F., Russell, I. T., & Hutchings, H. A. (2018) · Trials · doi:10.1186/s13063-018-2983-y · Cited by 39 · see citing works
Detailed systematic analysis of recruitment strategies in randomised controlled trials in patients with an unscheduled admission to hospital
Rowlands, C., Rooshenas, L., Fairhurst, K., Rees, J. R. E., Gamble, C. L., & Blazeby, J. M. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-018581 · Cited by 34 · see citing works
Surgeons’ and methodologists’ perceptions of utilising an expertise-based randomised controlled trial design: a qualitative study
Cook, J. A., Campbell, M., Gillies, K., & Skea, Z. (2018) · Trials · doi:10.1186/s13063-018-2832-z · Cited by 34 · see citing works
Using observational data for personalized medicine when clinical trial evidence is limited
Gershman, B., Guo, D. P., & Dahabreh, I. J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.04.005 · Cited by 32 · see citing works
Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial
Harji, D. P., Marshall, H. L., Gordon, K., Twiddy, M., Pullan, A., Meads, D. M., Croft, J., Burke, D., Griffiths, B., Verjee, A., et al. (2020) · British journal of surgery · doi:10.1002/bjs.11703 · Cited by 28 · see citing works
Deciding to Enrol in a Cancer Trial: A Systematic Review of Qualitative Studies
Viljoen, B., Chambers, S. K., Dunn, J. C., Ralph, N., & March, S. (2020) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s266281 · Cited by 26 · see citing works
Overcoming difficulties with equipoise to enable recruitment to a randomised controlled trial of partial ablation vs radical prostatectomy for unilateral localised prostate cancer
Elliott, D., Hamdy, F. C., Leslie, T. A., Rosario, D. J., Dudderidge, T. J., Hindley, R. G., Emberton, M., BREWSTER, S. F., Sooriakumaran, P., Catto, J. W. F., et al. (2018) · British Journal of Urology · doi:10.1111/bju.14432 · Cited by 27 · see citing works
Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308)
Sherratt, F. C., Brown, S. L., Haylock, B. J., Francis, P., Hickey, H., Gamble, C. L., Jenkinson, M. D., & Young, B. (2020) · The Oncologist · doi:10.1634/theoncologist.2019-0571 · Cited by 27 · see citing works
NeuroSAFE robot-assisted laparoscopic prostatectomy versus standard robot-assisted laparoscopic prostatectomy for men with localised prostate cancer (NeuroSAFE PROOF): protocol for a randomised controlled feasibility study
Dinneen, E. P., Haider, A., ALLEN, C. M., Freeman, A., Briggs, T. P., Nathan, S., Brew‐Graves, C., Grierson, J., Williams, N. R., Persad, R. A., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028132 · Cited by 26 · see citing works
The many faces of recruitment in a randomized controlled trial
Pinto, B. M., & DUNSIGER, S. I. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106285 · Cited by 23 · see citing works
Clinical trial recruitment in primary care: exploratory factor analysis of a questionnaire to measure barriers and facilitators to primary care providers’ involvement
Millar, M. M., Taft, T., & Weir, C. R. (2022) · BMC Family Practice · doi:10.1186/s12875-022-01898-2 · Cited by 24 · see citing works
Clinical research nursing and factors influencing success: a qualitative study describing the interplay between individual and organisational leadership influences and their impact on the delivery of clinical research in healthcare
Tinkler, L., & Robinson, L. J. (2020) · Journal of research in nursing · doi:10.1177/1744987120904778 · Cited by 20 · see citing works
Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study
on behalf of the GO CART team, Castillo, G., Lalu, M. M., Asad, S. S., Foster, M., Kekre, N. K., Fergusson, D. A., Hawrysh, T., Atkins, H. L., Thavorn, K., et al. (2021) · Trials · doi:10.1186/s13063-021-05121-y · Cited by 16 · see citing works
Recruitment patterns in multicentre randomised trials fit more closely to Price's Law than the Pareto Principle: A review of trials funded and published by the United Kingdom Health Technology Assessment Programme
Knowlson, C. N., Dean, A., Doherty, L., Fairhurst, C. M., Brealey, S., & Torgerson, D. J. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106665 · Cited by 18 · see citing works
Discussing surgical innovation with patients: a qualitative study of surgeons’ and governance representatives’ views
Zahra, J., Paramasivan, S., Blencowe, N., Cousins, S., AVERY, K. N. L., Mathews, J. A., Main, B., McNair, A., Hinchliffe, R. J., Blazeby, J. M., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-035251 · Cited by 18 · see citing works
Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT
Pickard, R. S., Goulão, B., Carnell, S. C., Shen, J., MacLennan, G., Norrie, J. D., Breckons, M., Vale, L. D., Whybrow, P., Rapley, T., et al. (2020) · Health Technology Assessment · doi:10.3310/hta24610 · Cited by 18 · see citing works
What Are Patients Told About Innovative Surgical Procedures? A Qualitative Synthesis of 7 Case Studies in the United Kingdom
Elliott, D., Ochieng, C., Zahra, J., McNair, A., Main, B., Skilton, A., Blencowe, N., Cousins, S., Paramasivan, S., Hoffmann, C., et al. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005714 · Cited by 17 · see citing works
Peritoneal Ultrafiltration for Heart Failure: Lessons from a Randomized Controlled Trial
Dukka, H., Kalra, P. A., Wilkie, M. E., Bhandari, S., Davies, S., Barratt, J., Squire, I. B., Odudu, A., Selby, N. M., McIntyre, C. W., et al. (2019) · Peritoneal Dialysis International · doi:10.3747/pdi.2018.00272 · Cited by 17 · see citing works
Recruiting Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis to Internet-Delivered Therapy: Internal Pilot Within a Randomized Controlled Trial
Anderson, E. C., Parslow, R. M., Hollingworth, W., Mills, N., Beasant, L., Gaunt, D., Metcalfe, C. D., Kessler, D. S., Macleod, J., Pywell, S., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/17768 · Cited by 17 · see citing works
Improving Food-Related Quality of Life in Inflammatory Bowel Disease through a Novel Web Resource: A Feasibility Randomised Controlled Trial
Cox, S. R., Czuber‐Dochan, W., Wall, C. L., Clarke, H. A. K., Drysdale, C., Lomer, M. C. E., Lindsay, J. O., & Whelan, K. (2022) · Nutrients · doi:10.3390/nu14204292 · Cited by 15 · see citing works
A Failed Method? Reflections on Using Audio Diaries in Uganda With Young People Growing Up With HIV in the BREATHER Trial
Bernays, S., Paparini, S., Namukwaya, S., & Seeley, J. (2018) · Qualitative Health Research · doi:10.1177/1049732318813534 · Cited by 16 · see citing works
Perceived barriers to randomised controlled trials in breast reconstruction: obstacle to trial initiation or opportunity to resolve? A qualitative study
on behalf of the iBRA Steering Group, Davies, G., Mills, N., Holcombe, C., & Potter, S. (2020) · Trials · doi:10.1186/s13063-020-4227-1 · Cited by 15 · see citing works
Optimising recruitment into trials using an internal pilot
Bertram, W., Moore, A. J., Wylde, V., & Gooberman‐Hill, R. (2019) · Trials · doi:10.1186/s13063-019-3296-5 · Cited by 16 · see citing works
Enhancing communication, informed consent and recruitment in a paediatric urgent care surgical trial: a qualitative study
Sherratt, F. C., Beasant, L., Crawley, E. M., Hall, N. J., & Young, B. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-02040-w · Cited by 15 · see citing works
Community aquatic therapy for Parkinson’s disease: an international qualitative study
Carroll, L. M., Morris, M. E., O'Connor, W. T., & Clifford, A. M. (2021) · Disability and Rehabilitation · doi:10.1080/09638288.2021.1906959 · Cited by 15 · see citing works
Success and failure factors of patient recruitment for industry-sponsored clinical trials and the role of the electronic health records—a qualitative interview study in the Nordic countries
Laaksonen, N., Bengtström, M., Axelin, A., Blomster, J., Scheinin, M., & Huupponen, R. (2022) · Trials · doi:10.1186/s13063-022-06144-9 · Cited by 14 · see citing works
Uncovering key clinical trial features influencing recruitment
Idnay, B., Fang, Y., Butler, A. M., Moran, J. A., Li, Z., Lee, J., Ta, C., Liu, C., Yuan, C., Chen, H., et al. (2023) · Journal of Clinical and Translational Science · doi:10.1017/cts.2023.623 · Cited by 14 · see citing works
Total Sleep Deprivation Followed by Bright Light Therapy as Rapid Relief for Depression: A Pragmatic Randomized Controlled Trial
Ioannou, M., Szabó, Z., Widmark-Jensen, M., Vyrinis, G., Karlsson, C., & Steingrimsson, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.705090 · Cited by 13 · see citing works
A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders
Peterson, B. S., West, A. E., Weisz, J. R., Mack, W. J., Kipke, M. D., Findling, R. L., Mittman, B. S., Bansal, R., Piantadosi, S., Takata, G., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03314-y · Cited by 13 · see citing works
Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)
Husbands, S., Elliott, D., Davis, T. R. C., Blazeby, J. M., Harrison, E., Montgomery, A. A., Sprange, K., Duley, L., Karantana, A., Hollingworth, W., et al. (2020) · Pilot and Feasibility Studies · doi:10.1186/s40814-020-00710-1 · Cited by 13 · see citing works
Protective parents and permissive children: what qualitative interviews with parents and children can tell us about the feasibility of juvenile idiopathic arthritis trials
Sherratt, F. C., Roper, L., Stones, S. R., McErlane, F., Peak, M., Beresford, M. W., Foster, H., Ramanan, A. V., Rooney, M. E., Baildam, E. M., et al. (2018) · Pediatric Rheumatology · doi:10.1186/s12969-018-0293-2 · Cited by 12 · see citing works
The role of accreditation on financial innovation and business sustainability: a study of AACSB-accredited business schools in the GCC region
AlDhaen, E. S., & Braendle, U. (2023) · Competitiveness Review An International Business Journal incorporating Journal of Global Competitiveness · doi:10.1108/cr-08-2023-0204 · Cited by 12 · see citing works
Does the provision of a DVD-based audio-visual presentation improve recruitment in a clinical trial? A randomised trial of DVD trial invitations
Rogers, A., Flynn, R., Mackenzie, I. S., & MacDonald, T. M. (2019) · BMC Medical Research Methodology · doi:10.1186/s12874-019-0663-6 · Cited by 12 · see citing works
Autopsy of a failed trial part 1: A qualitative investigation of clinician's views on and experiences of the implementation of the DAISIES trial in UK‐based intensive eating disorder services
Phillips, M. D., İnce, B., Webb, H., Dalton, B., McCombie, C., Irish, M., Mercado, D., Peachey, G., Zenasni, Z., Himmerich, H., et al. (2023) · European Eating Disorders Review · doi:10.1002/erv.2975 · Cited by 12 · see citing works
Using evidence when planning for trial recruitment: An international perspective from time-poor trialists
Gardner, H., Treweek, S. P., & Gillies, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226081 · Cited by 12 · see citing works
Consent Rates Reported in Published Pediatric Randomized Controlled Trials
Lonhart, J. A., Edwards, A. R., Agarwal, S., Lucas, B., & Schroeder, A. R. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.06.058 · Cited by 12 · see citing works
Prostate Tuberculosis: six forms of clinical presentation
de Figueiredo, A. A., Lopes, H. E., Barreto, A. D. A., Fanni, V. S. S., & Netto, J. M. B. (2024) · International braz j urol · doi:10.1590/s1677-5538.ibju.2023.0299 · Cited by 12 · see citing works
Embedding qualitative research in randomised controlled trials to improve recruitment: findings from two recruitment optimisation studies of orthopaedic surgical trials
Scantlebury, A., McDaid, C., Brealey, S., Cook, L., Sharma, H., Ranganathan, A., Adamson, J., & teams, O. B. O. T. A. A. P. S. (2021) · Trials · doi:10.1186/s13063-021-05420-4 · Cited by 11 · see citing works
“And Then He Got into the Wrong Group”: A Qualitative Study Exploring the Effects of Randomization in Recruitment to a Randomized Controlled Trial
Lehmann, B. A., Lindert, L., Ohlmeier, S., Schlomann, L., Pfaff, H., & Choi, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17061886 · Cited by 11 · see citing works
The integration of rapid qualitative research in clinical trials: reflections from the ward-based goal-directed fluid therapy (GDFT) in acute pancreatitis feasibility trial
Vindrola‐Padros, C., Froghi, F., Gopalan, V., Maruthan, S., Filipe, H., McNeil, M., Garcia, S. M., Davidson, B. R., & on behalf of the GAP trial team (2023) · Trials · doi:10.1186/s13063-023-07191-6 · Cited by 10 · see citing works
The role of the nurse in supporting cancer clinical trials
Lavender, V., & Croudass, A. (2019) · British Journal of Nursing · doi:10.12968/bjon.2019.28.4.s14 · Cited by 10 · see citing works
Effects of an eating club for people with a psychotic disorder on personal recovery: Results of a randomized controlled trial
Vogel, J. S., Bruins, J., Swart, M., Liemburg, E. J., van der Gaag, M., & Castelein, S. (2023) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2023.101871 · Cited by 8 · see citing works
A patient-focused, theory-guided approach to survey design identified barriers to and drivers of clinical trial participation
Brehaut, J., Carroll, K. A., Presseau, J., Richards, D. P., Gordon, J., Bénard, A., Hudek, N., Graham, I. D., Fergusson, D. A., & Marlin, S. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.12.013 · Cited by 9 · see citing works
Rationale for participation in venous leg ulcer clinical research: Patient interview study
Weller, C. D., Richards, C., Turnour, L., & Victoria Team (2020) · International Wound Journal · doi:10.1111/iwj.13438 · Cited by 9 · see citing works
Using qualitative research methods to understand how surgical procedures and devices are introduced into NHS hospitals: the Lotus study protocol
Elliott, D., Blencowe, N., Cousins, S., Zahra, J., Skilton, A., Mathews, J. A., Paramasivan, S., Hoffmann, C., McNair, A., Ochieng, C., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049234 · Cited by 9 · see citing works
Using a theory-informed approach to explore patient and staff perspectives on factors that influence clinical trial recruitment for patients with cirrhosis and small oesophageal varices
Boutillier, C. L., Snowdon, C., Patel, V., McPhail, M. J. W., Ward, C., Carter, B., Uddin, R., Zamalloa, A., & Lawrence, V. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263288 · Cited by 9 · see citing works
Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience
Buccheri, S., James, S. K., Mafham, M., Landray, M., Melvin, T., Oldgren, J., Bulbulia, R. A., Bowman, L. J., Hoogervorst, L. A., de Mheen, P. J. M., et al. (2025) · Trials · doi:10.1186/s13063-025-08724-x · Cited by 8 · see citing works
Factors Underlying Patient and Surgeon Willingness to Participate in a Placebo Surgery Controlled trial
Bunzli, S., Nelson, E., Wall, L., Schilling, C. G., Lohmander, S. L., Balogh, Z. J., Tran, P., Paolucci, F., Clarke, P., Choong, P., et al. (2021) · Annals of Surgery Open · doi:10.1097/as9.0000000000000104 · Cited by 8 · see citing works
Patient and health practitioner views and experiences of a cancer trial before and during COVID-19: qualitative study
Sherratt, F. C., Fisher, P., Mathieson, A., Cherry, M. G., Pettitt, A. R., & Young, B. (2022) · Trials · doi:10.1186/s13063-022-06453-z · Cited by 8 · see citing works
Understanding Patient Perceptions Towards Direct Primary Care: A Focus Group Study
Tou, L. C., Jeyakumar, S. J., Siddiqui, T. A., Ravi, S. N., & Prakash, N. (2022) · Journal of Patient Experience · doi:10.1177/23743735221117359 · Cited by 8 · see citing works
Towards a Therapy for Geographic Atrophy: A Patient’s Experience
Enoch, J., Ghulakhszian, A., Sekhon, M., Crabb, D. P., Taylor, D. J., & Dinah, C. (2023) · Patient Preference and Adherence · doi:10.2147/ppa.s386662 · Cited by 8 · see citing works
Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study
Jones, A. P., Clayton, D., Nkhoma, G., Sherratt, F. C., Peak, M., Stones, S. R., Roper, L., Young, B., McErlane, F., Moitt, T., et al. (2020) · Health Technology Assessment · doi:10.3310/hta24360 · Cited by 9 · see citing works
Views of healthcare professionals on recruiting to a psychosocial randomised controlled trial: a qualitative study
Aspden, T., Armstrong, M., & Serfaty, M. A. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-06817-2 · Cited by 7 · see citing works
Maternity care providers’ involvement in research
Shiplo, S., Meaney, S., & O’Donoghue, K. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.05.021 · Cited by 7 · see citing works
The TOPSY pessary self-management intervention for pelvic organ prolapse: a study protocol for the process evaluation
Bugge, C., Kearney, R., Dembinsky, M., Khunda, A., Graham, M., Agur, W., Breeman, S., Dwyer, L., Elders, A., Forrest, M., et al. (2020) · Trials · doi:10.1186/s13063-020-04729-w · Cited by 7 · see citing works
Generalizability and reach of a randomized controlled trial to improve oral health among home care recipients: comparing participants and nonparticipants at baseline and during follow-up
Czwikla, J., Herzberg, A., Kapp, S., Kloep, S., Rothgang, H., Nitschke, I., Haffner, C., & Hoffmann, F. (2022) · Trials · doi:10.1186/s13063-022-06470-y · Cited by 6 · see citing works
Energy and protein intake in medical and geriatric inpatients with MEDPass versus conventional administration of oral nutritional supplements: study protocol for the randomized controlled MEDPass Trial
Kurmann, S., Reber, E., Vasiloglou, M., Schuetz, P., Schoenenberger, A., Uhlmann, K., Sterchi, A., & Stanga, Z. (2021) · Trials · doi:10.1186/s13063-021-05145-4 · Cited by 4 · see citing works
The role of healthcare professionals’ communication in trial participation decisions: a qualitative investigation of recruitment consultations and patient interviews across three RCTs
Farrar, N., Elliott, D., Jepson, M., Young, B., Donovan, J., Conefrey, C., Realpe, A. X., Mills, N., Wade, J., Lim, E. K. S., et al. (2024) · Trials · doi:10.1186/s13063-024-08656-y · Cited by 6 · see citing works
The Development of the Australian National Palliative Care Clinical Studies Collaborative “Integrating Qualitative Research into Clinical Trials Framework”
Philip, J. A. M., Collins, A., Phillips, J. L., Luckett, T., Morgan, D. D., Lobb, E. A., DiGiacomo, M. L., Kochovska, S., Brown, L., & Currow, D. C. (2020) · Journal of Palliative Medicine · doi:10.1089/jpm.2020.0480 · Cited by 6 · see citing works
“Nothing to lose and the possibility of gaining”: a qualitative study on the feasibility and acceptability of registry-based randomised controlled trials among cancer patients and clinicians
Prang, K.-H., Karanatsios, B., Zhang, A., Verbunt, E., Wong, H., Wong, V., Gately, L., Tran, B., Gibbs, P., & Kelaher, M. (2023) · Trials · doi:10.1186/s13063-023-07109-2 · Cited by 6 · see citing works
Recruitment challenges in stroke rehabilitation randomized controlled trials: a qualitative exploration of trialists’ perspectives using Framework analysis
McGill, K., McGarry, J., Sackley, C. M., Godwin, J., Nicoll, A., & Brady, M. (2020) · Clinical Rehabilitation · doi:10.1177/0269215520930796 · Cited by 6 · see citing works
Feasibility and outcomes of fibreoptic endoscopic evaluation of swallowing following prophylactic swallowing rehabilitation in head and neck cancer
Patterson, J., Toft, K., McAuley, F., King, E., McLachlan, K., Roe, J. W. G., & Wells, M. (2019) · Clinical Otolaryngology · doi:10.1111/coa.13331 · Cited by 6 · see citing works
“The Truth Is, We Must Miss Some”: A Qualitative Study of the Patient Eligibility Screening Process, and Automation Perspectives, for Cancer Clinical Trials
Rosa, A. L., Vaterkowski, M., Marc Cuggia, A., Campillo‐Gimenez, B., Tournigand, C., BAUJAT, B., Daniel, C., Kempf, E., & Lamé, G. (2024) · Cancer Medicine · doi:10.1002/cam4.70466 · Cited by 4 · see citing works
Feasibility and Relevance of an Intervention with Systematic Screening as a Base for Individualized Rehabilitation in Breast Cancer Patients: A Pilot Trial of the ReScreen Randomized Controlled Trial
Olsson, I.-M., Malmström, M., Rydén, L., & Möller, U. (2022) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s355055 · Cited by 5 · see citing works
Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives
Twiddy, M., Birtwistle, J. C., Edmondson, A., Croft, J., Gordon, K., Meads, D. M., Burke, D., Griffiths, B., Rose, A., Sagar, P. M., et al. (2022) · BJS Open · doi:10.1093/bjsopen/zrac137 · Cited by 5 · see citing works
Development and Initial Feasibility Testing of the Virtual Research Navigator (VRN): A Public-Facing Agent-Based Educational System for Clinical Research Participation
Mozgai, S., Hartholt, A., Akinyemi, D., Kubicek, K., Rizzo, A., & Kipke, M. D. (2020) · Communications in computer and information science · doi:10.1007/978-3-030-50729-9_43 · Cited by 4 · see citing works
Stakeholder perspectives on barriers and enablers to recruiting anxious children undergoing day surgery under general anaesthetic: a qualitative internal pilot study of the MAGIC randomised controlled trial
Kettle, J., Deery, C., BOLT, R. J., Papaioannou, D. E., & Marshman, Z. (2021) · Trials · doi:10.1186/s13063-021-05425-z · Cited by 4 · see citing works
ROBOCOP II (ROBOtic assisted versus conventional open partial nephrectomy) randomised, controlled feasibility trial: clinical trial protocol
Kowalewski, K., Abate, M. A. S., Neuberger, M., Kirchner, M., Brinster, R., Egen, L., Haney, C. M., Siegel, F. P., Michel, M. S., Honeck, P. R., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-052087 · Cited by 4 · see citing works
Understanding potential barriers and enablers to a perioperative early phase cell therapy trial
Foster, M., Fergusson, D. A., Hunniford, V. T., Cardenas, A., Castillo, G., Yaworsky, J., Mazer, C. D., Devereaux, P. J., McIsaac, D. I., Stewart, D. J., et al. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.08.008 · Cited by 3 · see citing works
Can learnings from the COVID-19 pandemic improve trial conduct post-pandemic? A case study of strategies used by the DISC trial
Knowlson, C. N., Tharmanathan, P., Arundel, C., James, S., Flett, L., Gascoyne, S., Welch, C., Warwick, D. J., & Dias, J. J. (2022) · Research Methods in Medicine & Health Sciences · doi:10.1177/26320843221128296 · Cited by 4 · see citing works
Clinical reasoning in pragmatic trial randomization: a qualitative interview study
Clapp, J. T., Dinh, C., Hsu, M., & Neuman, M. D. (2023) · Trials · doi:10.1186/s13063-023-07445-3 · Cited by 4 · see citing works
Lessons learned from a randomized controlled trial on a home delivered meal service in advanced cancer patients undergoing chemotherapy: a pilot study
IJmker-Hemink, V. E., Lize, N., Beijer, S., Raijmakers, N. J. H., Wanten, G. J. A., & van den Berg, M. G. A. (2021) · BMC Nutrition · doi:10.1186/s40795-021-00407-5 · Cited by 4 · see citing works
Re: Radical Cystectomy (Bladder Removal) Against Intravesical BCG Immunotherapy for High-risk Non-muscle Invasive Bladder Cancer (BRAVO): A Protocol for a Randomised Controlled Feasibility Study
Pang, K. H., & Noon, A. P. (2017) · European Urology · doi:10.1016/j.eururo.2017.12.007 · Cited by 4 · see citing works
Consultations about randomised controlled trials are shorter and less in-depth for socioeconomically disadvantaged patients compared to socioeconomically advantaged patients: qualitative analysis across three trials
Popa, M., Young, B., Rousseau, N. S., Cherry, M. G., Jenkins, I., Cloke, J., Pettitt, A. R., Jenkinson, M. D., Ahmed, S., Pemberton, A., et al. (2024) · Trials · doi:10.1186/s13063-024-08216-4 · Cited by 3 · see citing works
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Authors: Elliott, D., Husbands, S., Hamdy, F. C., Holmberg, L., & Donovan, J. L.
Affiliations: University of Bristol (GB)
University of Oxford (GB)
Uppsala University (SE)
Corresponding author: Elliott, Daisy
ORCID: Elliott, Daisy
Husbands, Samantha
Hamdy, Freddie C.
Holmberg, Lars
Donovan, Jenny L.
Venue: European Urology
Publisher: Elsevier BV
Published: 2017-11
Volume: 72
Issue: 5
Pages: 789-798
ISSN: 0302-2838 (ISSN-L)
DOI: 10.1016/j.eururo.2017.04.036
OpenAlex: W2620883902
Cited by: 161
References: 59
Citations by year: 2026: 5 · 2025: 12 · 2024: 12 · 2023: 19 · 2022: 22 · 2021: 35 · 2020: 29 · 2019: 12 · 2018: 11 · 2017: 4
FWCI: 2.49
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: European Urology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
Bristol Research (University of Bristol) (submittedVersion, cc-by-nc-nd)
Funders: University Hospitals Bristol NHS Foundation Trust
National Institute for Health and Care Research (NF-SI-0513-10121)
Royal College of Surgeons of England
Medical Research Council (MR/K025643/1)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords: clinical trial recruitment, recruitment barriers, informed consent, organizational barriers, equipoise, patient eligibility, qualitative research
MeSH terms: Attitude of Health Personnel, Emotions, Humans, Health Knowledge, Attitudes, Practice, Research Personnel, Randomized Controlled Trials as Topic, Workload, Sample Size, Patient Selection, Qualitative Research, Workflow

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Understanding and improving recruitment to randomised controlled trials: qualitative research approaches

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