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Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathology.

Klenkler, Bettina, Sheardown, Heather·2004·Experimental Eye Research
DOI 10.1016/j.exer.2004.07.008
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Abstract

A number of growth factors and their associated receptors, including epidermal growth factor, transforming growth factor-beta, keratinocyte growth factor, hepatocyte growth factor, fibroblast growth factor and platelet-derived growth factor have been detected in the anterior segment of the eye. On binding to cellular receptors, these factors activate signalling cascades, which regulate functions including mitosis, differentiation, motility and apoptosis. Production of growth factors by corneal cells and their presence in the tear fluid and aqueous humour is essential for maintenance and renewal of normal tissue in the anterior eye and the prevention of undesirable immune or angiogenic reactions. Growth factors also play a vital role in corneal wound healing, mediating the proliferation of epithelial and stromal tissue and affecting the remodelling of the extracellular matrix (ECM). These functions depend on a complex interplay between growth factors of different types, the ECM, and regulatory mechanisms of the affected cells. Imbalances may lead to deficient wound healing and various ocular pathologies, including edema, neovascularization and glaucoma. Growth factors may be targeted in therapeutic ophthalmic applications, through exogenous application or selective inhibition, and may be used to elicit specific cellular responses to ophthalmic materials. A thorough understanding of the mechanism and function of growth factors and their actions in the complex environment of the…

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  • Improved tissue maintenance is typically accompanied by healthy remodeling.

    “Finally, improved tissue maintenance is typically accompanied by a healthy remodeling [77, 84, 85]”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [77]

  • Modulation of multiple key cell-fate regulatory pathways, including attenuation of pSmad2,3 signaling by follistatin, is important for productive cell proliferation and regeneration in skeletal muscle, heart, and generally throughout the body.

    “Modulation of multiple key cell-fate regulatory pathways, including attenuation of pSmad2,3 signaling by follistatin, is important for productive cell proliferation and regeneration in skeletal muscle, heart and generally, throughout the body [77–79].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [77]

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Research works printed but not linked: 91

  1. Baldwin, 2002, Growth factors in corneal wound healing following refractive surgery: a review, Acta Ophthalmol. Scand., 80, 238, 10.1034/j.1600-0420.2002.800303.x · DOI
  2. Blake, 1997, Matrix stimulates the proliferation of human corneal endothelial cells in culture, Invest. Ophthalmol. Vis. Sci., 38, 1119
  3. Boilly, 2000, FGF signals for cell proliferation and migration through different pathways, Cytokine Growth Factor Rev., 11, 295, 10.1016/S1359-6101(00)00014-9 · DOI
  4. Brown, 1999, Characterization of proteoglycans synthesized by cultured corneal fibroblasts in response to transforming growth factor β and fetal calf serum, J. Biol. Chem., 274, 7111, 10.1074/jbc.274.11.7111 · DOI
  5. Carpenter, 1979, Epidermal growth factor, Annu. Rev. Biochem., 48, 193, 10.1146/annurev.bi.48.070179.001205 · DOI
  6. Chirila T.V., 2001. An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application. Biomaterials 22, 3311–3317. · DOI
  7. Chung, 1989, Treatment of rabbit corneal alkali wounds with human epidermal growth factor, Cornea, 8, 122, 10.1097/00003226-198906000-00008 · DOI
  8. Dinbergs, 1996, Cellular response to transforming growth factor-β1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions, J. Biol. Chem., 271, 29822, 10.1074/jbc.271.47.29822 · DOI
  9. Dupuy, 2001, Chemotactic penetration of keratocytes in ePTFE polymer in vitro, J. Biomed. Mater. Res., 56, 487, 10.1002/1097-4636(20010915)56:4<487::AID-JBM1120>3.0.CO;2-# · DOI
  10. Finch, 1989, Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth, Science, 245, 752, 10.1126/science.2475908 · DOI
  11. Fini, 1999, Keratocyte and fibroblast phenotypes in the repairing cornea, Prog. Retin. Eye Res., 18, 529, 10.1016/S1350-9462(98)00033-0 · DOI
  12. Fujikawa, 1984, Basement membrane components in healing rabbit corneal epithelial wounds: immunofluorescence and ultrastructural studies, J. Cell Biol., 98, 128, 10.1083/jcb.98.1.128 · DOI
  13. Funderburgh, 2001, Proteoglycan expression during transforming growth factor β-induced keratocyte-myofibroblast transdifferentiation, J. Biol. Chem., 276, 44173, 10.1074/jbc.M107596200 · DOI
  14. Grant, 1992, Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor-beta on corneal cell chemotaxis, Invest. Ophthalmol. Vis. Sci., 33, 3292
  15. Grierson, 2000, Hepatocyte growth factor/scatter factor in the eye, Prog. Retin. Eye Res., 19, 779, 10.1016/S1350-9462(00)00015-X · DOI
  16. Gupta, 1996, Transforming growth factor beta-1 and beta-2 in human tear fluid, Curr. Eye Res., 15, 605, 10.3109/02713689609008900 · DOI
  17. Hongo, 1992, Distribution of epidermal growth factor (EGF) receptors in rabbit corneal epithelial cells, keratocytes and endothelial cells, and the changes induced by transforming growth factor-β1, Exp. Eye Res., 54, 9, 10.1016/0014-4835(92)90063-X · DOI
  18. Honma, 1997, Effect of transforming growth factor-β1 and -β2 on in vitro rabbit corneal epithelial cell proliferation promoted by epidermal growth factor, keratinocyte growth factor, or hepatocyte growth factor, Exp. Eye Res., 65, 391, 10.1006/exer.1997.0338 · DOI
  19. Imanishi, 2000, Growth factors: importance in wound healing and maintenance of transparency of the cornea, Prog. Retin. Eye Res., 19, 113, 10.1016/S1350-9462(99)00007-5 · DOI
  20. Ito, 1998, Tissue engineering by immobilized growth factors, Mater. Sci. Eng. C, 6, 267, 10.1016/S0928-4931(98)00061-7 · DOI
  21. Jester, 2002, TGF beta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF beta, PDGF and integrin signaling, Exp. Eye Res., 75, 645, 10.1006/exer.2002.2066 · DOI
  22. Jones, 2000, Connecting signaling and cell cycle progression in growth factor-stimulated cells, Oncogene, 19, 5558, 10.1038/sj.onc.1203858 · DOI
  23. Jorissen, 2003, Epidermal growth factor receptor: mechanisms of activation and signaling, Exp. Cell Res., 284, 31, 10.1016/S0014-4827(02)00098-8 · DOI · Paper page
  24. Joussen, 2003, VEGF-dependent conjunctivalization of the corneal surface, Invest. Ophthalmol. Vis. Sci., 44, 117, 10.1167/iovs.01-1277 · DOI
  25. Kitazawa, 1990, The mechanism of accelerated corneal epithelial healing by human epidermal growth factor, Invest. Ophthalmol. Vis. Sci., 31, 1773
  26. Klenkler, B.J., Griffith, M., Sheardown, H., 2004. EGF grafted surfaces in artificial corneal applications. Biomaterials. Submitted. · DOI
  27. Kokawa, 1996, High total TGF-β levels in normal human tears, Curr. Eye Res., 15, 341, 10.3109/02713689609007630 · DOI
  28. Kruse, 1993, Growth factors modulate clonal growth and differentiation of cultured rabbit limbal and corneal epithelium, Invest. Ophthalmol. Vis. Sci., 34, 1963
  29. Kuhl, 1996, Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase, Nat. Med., 2, 1022, 10.1038/nm0996-1022 · DOI
  30. Lambiase, 1998, Topical treatment with nerve growth factor for corneal neurotrophic ulcers, N. Engl. J. Med., 338, 1174, 10.1056/NEJM199804233381702 · DOI
  31. Lambiase, 1998, Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases, Invest. Ophthalmol. Vis. Sci., 39, 1272
  32. Lambiase, 2000, Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas, Invest. Ophthalmol. Vis. Sci., 41, 1063
  33. Lambiase, 2002, Intraocular production and release of nerve growth factor after iridectomy, Invest. Ophthalmol. Vis. Sci., 43, 2334
  34. Li, 1995, Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface, J. Cell. Physiol., 163, 61, 10.1002/jcp.1041630108 · DOI
  35. Li, 1997, Differential regulation of keratinocyte growth factor and hepatocyte growth factor/scatter factor by different cytokines in human corneal and limbal fibroblasts, J. Cell. Physiol., 172, 361, 10.1002/(SICI)1097-4652(199709)172:3<361::AID-JCP10>3.0.CO;2-9 · DOI
  36. Lim, 2003, Growth factor, cytokine and protease interactions during corneal wound healing, Ocular Surface, 1, 53, 10.1016/S1542-0124(12)70128-3 · DOI
  37. Lu, 2001, Corneal epithelial wound healing, Exp. Biol. Med., 226, 653, 10.1177/153537020222600711 · DOI
  38. Majima, 1998, Cell biological analysis with respect to cause of fibrous opacification of the anterior capsule after cataract extraction, Opthalmologica, 212, 364, 10.1159/000027369 · DOI
  39. Maldonado, 1995, Epidermal growth factor stimulates integrin-mediated cell migration of cultured human corneal epithelial cells on fibronectin and arginine-glycine-aspartic acid peptide, Invest. Ophthalmol. Vis. Sci., 36, 2120
  40. Maltseva, 2001, Fibroblast growth factor reversal of the corneal myofibroblast phenotype, Invest. Ophthalmol. Vis. Sci., 42, 2490
  41. McBain, 2003, HGF, MAPK, and a small physiological electric field interact during corneal epithelial cell migration, Invest. Ophthalmol. Vis. Sci., 44, 540, 10.1167/iovs.02-0570 · DOI
  42. Nakamura, 2003, Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration, Cornea, 22, 355, 10.1097/00003226-200305000-00014 · DOI
  43. Nakamura, 2001, The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis, Exp. Eye Res., 72, 511, 10.1006/exer.2000.0979 · DOI
  44. Namiki, 1992, Presence of human epidermal growth factor (hEGF), basic fibroblast growth factor (bFGF) in human aqueous, Nippon Ganka Gakkai Zasshi, 96, 652
  45. Nathan, 1991, Cytokines in context, J. Cell Biol., 113, 981, 10.1083/jcb.113.5.981 · DOI
  46. Nezu, 1992, Recombinant human epidermal growth factor and corneal neovascularization, Jpn J. Ophthalmol., 36, 401
  47. Nishida, 1984, Fibronectin synthesis by the rabbit cornea: effects of mouse epidermal growth factor and cyclic AMP analogs, Jpn J. Ophthalmol., 28, 196
  48. Nishida, 1990, Differential modes of action of fibronectin and epidermal growth factor on rabbit corneal epithelial migration, J. Cell. Physiol., 145, 549, 10.1002/jcp.1041450323 · DOI
  49. Ohashi, 1989, Presence of epidermal growth factor in human tears, Invest. Ophthalmol. Vis. Sci., 30, 1879
  50. Ohji, 1993, Transforming growth factor-beta stimulates collagen and fibronectin synthesis by human corneal stromal fibroblasts in vitro, Curr. Eye Res., 12, 703, 10.3109/02713689308995765 · DOI
  51. Ohji, 1993, Corneal epithelial cell attachment with endogenous laminin and fibronectin, Invest. Ophthalmol. Vis. Sci., 34, 2487
  52. Parelman, 1990, Epidermal growth factor in human aqueous humor, Am. J. Ophthalmol., 109, 603, 10.1016/S0002-9394(14)70698-1 · DOI
  53. Pasquale, 1993, Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye, Invest. Ophthalmol. Vis. Sci., 34, 23
  54. Rieck, 2001, Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro, Exp. Eye Res., 73, 639, 10.1006/exer.2001.1067 · DOI
  55. Roberts, 2002, The ever-increasing complexity of TGF-β signaling, Cytokine Growth Factor Rev., 13, 3, 10.1016/S1359-6101(01)00027-2 · DOI
  56. Rolando, 2001, The ocular surface and tear film and their dysfunction in dry eye disease, Surv. Ophthalmol., 45, S203, 10.1016/S0039-6257(00)00203-4 · DOI
  57. Rubin, 1989, Purification and characterization of a newly identified growth factor specific for epithelial cells, Proc. Natl Acad. Sci. USA, 86, 802, 10.1073/pnas.86.3.802 · DOI
  58. Saghizadeh, 2001, Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas, Exp. Eye Res., 73, 179, 10.1006/exer.2001.1028 · DOI
  59. Sakamoto, 2000, Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis, Gene Ther., 7, 1915, 10.1038/sj.gt.3301320 · DOI
  60. Sheardown, 1996, Mechanisms of corneal epithelial wound healing, Chem. Eng. Sci., 51, 4517, 10.1016/0009-2509(96)00299-0 · DOI
  61. Shimmura, S., Doillon, C.J., Griffith, M., Nakamura, M., Gagnon, E., Usui, A., Tsubota, K., 2003. Collagen‐poly (N‐isopropylacrylamide) based membranes for corneal stroma scaffolds. Cornea 22, S81–S88. · DOI
  62. Smith, 1998, Clearing the cornea with nerve growth factor, N. Engl J. Med., 338, 1222, 10.1056/NEJM199804233381710 · DOI
  63. Song, 2001, Injury and EGF mediate the expression of α6β4 integrin subunits in corneal epithelium, J. Cell. Biochem., 80, 397, 10.1002/1097-4644(20010301)80:3<397::AID-JCB140>3.0.CO;2-W · DOI
  64. Song, 2002, TGF-β1 regulates TGF-β1 and FGF-2 mRNA expression during fibroblast wound healing, Mol. Pathol., 55, 164, 10.1136/mp.55.3.164 · DOI
  65. Song, 2003, Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit β4, Cell Tissue Res., 312, 203, 10.1007/s00441-002-0693-x · DOI
  66. Sorkin, 2002, Signal transduction and endocytosis: close encounters of many kinds, Nat. Rev. Mol. Cell. Biol., 3, 600, 10.1038/nrm883 · DOI
  67. Sotozono, 1994, Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth, Exp. Eye Res., 59, 385, 10.1006/exer.1994.1122 · DOI
  68. Streilein, 2000, Does innate immune privilege exist?, J. Leukoc. Biol., 67, 479, 10.1002/jlb.67.4.479 · DOI
  69. Streilein, 2002, The eye's view of antigen presentation, Hum. Immunol., 63, 435, 10.1016/S0198-8859(02)00393-2 · DOI
  70. Suuronen, E.J., Nakamura, M., Watsky, M.A., Stys, P.K., Muller, L.J., Munger, R., Shinozaki, N., Griffith, M., 2004. Innervated human corneal equivalents as in vitro models for nerve‐target cell interactions. FASEB J. 18, 170–172. · DOI
  71. Suzuki, 2003, Cell-matrix and cell–cell interactions during corneal epithelial wound healing, Prog. Retin. Eye Res., 22, 113, 10.1016/S1350-9462(02)00042-3 · DOI
  72. Taniguchi, 1991, The effect of recombinant epidermal growth factor in corneal angiogenesis, Nippon Ganka Gakkai Zasshi, 95, 52
  73. Tervo, 1997, Tear hepatocyte growth factor (HGF) availability increases markedly after excimer laser surface ablation, Exp. Eye Res., 64, 501, 10.1006/exer.1996.0226 · DOI
  74. Trinkaus-Randall, 1998, Biological response to a synthetic cornea, J. Control. Release, 53, 205, 10.1016/S0168-3659(97)00254-X · DOI
  75. Tripathi, 1991, Analysis of human aqueous humor for epidermal growth factor, Exp. Eye. Res., 53, 407, 10.1016/0014-4835(91)90247-C · DOI
  76. Tripathi, 1994, Trabecular cells express the TGF-β2 gene and secrete the cytokine, Exp. Eye Res., 58, 523, 10.1006/exer.1994.1046 · DOI
  77. Tripathi, 1994, Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2, Exp. Eye Res., 59, 723, 10.1006/exer.1994.1158 · DOI
  78. Van Setten, 1997, Vascular endothelial growth factor (VEGF) in normal human corneal epithelium: detection and physiological importance, Acta Ophthalmol. Scand., 75, 649, 10.1111/j.1600-0420.1997.tb00623.x · DOI
  79. Van Setten, 1996, Growth factors and their receptors in the anterior chamber. Absence of epidermal growth factor and transforming growth factor alpha in human aqueous humor, Ophthalmic Res., 28, 361
  80. Welge-Lüβen, 2001, Role of tissue growth factors in aqueous humor homeostasis, Curr. Opin. Ophthalmol., 12, 94, 10.1097/00055735-200104000-00003 · DOI
  81. Wilson, 1999, Stimulus-specific and cell type-specific cascades: emerging principles relating to control of apoptosis in the eye, Exp. Eye Res., 69, 255, 10.1006/exer.1999.0698 · DOI
  82. Wilson, 1994, Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea, Exp. Eye Res., 59, 63, 10.1006/exer.1994.1081 · DOI
  83. Wilson, 1994, Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells, Exp. Eye Res., 59, 665, 10.1006/exer.1994.1152 · DOI
  84. Wilson, 1999, Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding, Exp. Eye Res., 68, 377, 10.1006/exer.1998.0603 · DOI
  85. Wilson, 1999, Stromal–epithelial interactions in the cornea, Prog. Retin. Eye Res., 18, 293, 10.1016/S1350-9462(98)00017-2 · DOI
  86. Wilson, 1999, Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding, Invest. Ophthalmol. Vis. Sci., 40, 2185
  87. Wilson, 2001, The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells, Prog. Retin. Eye Res., 20, 625, 10.1016/S1350-9462(01)00008-8 · DOI
  88. Wu, 1998, In vivo comparison of three different porous materials intended for use in a keratoprosthesis, Br. J. Ophthalmol., 82, 569, 10.1136/bjo.82.5.569 · DOI
  89. Yanai, 2002, Mitogenic and antiapoptotic effects of various growth factors on human corneal fibroblasts, Invest. Ophthalmol. Vis. Sci., 43, 2122
  90. You, 2000, Neurotrophic factors in the human cornea, Invest. Ophthalmol. Vis. Sci., 41, 692
  91. Zhao, 2001, Role of tears in keratocyte loss after epithelial removal in mouse cornea, Invest. Ophthalmol. Vis. Sci., 42, 1743

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Authors
Klenkler, B., & Sheardown, H.
Venue
Experimental Eye Research
Publisher
Elsevier BV
Published
2004-11
Volume
79
Issue
5
Pages
677-688
ISSN
0014-4835
DOI
10.1016/j.exer.2004.07.008
Cited by
146
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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