The DOI matches its Crossref record; 154 of the 162 references it cites were found in a registry or an index.
RPE lipofuscin and its role in retinal pathobiology
Abstract
Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues.
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“Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in the cells of the retinal pigment epithelium might reach levels that contribute to a decline in cell function, retinal ageing, and degeneration, mainly in the form of geographic atrophy.128”
From Age-related macular degeneration (2008) · cites this paper as [128]
Citations
Cites
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Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration
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Identification of the gene responsible for Best macular dystrophy
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Flagged first, then by citations
8 of the 162 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Dayhaw-Barker, 2001, The phototoxicity of aged RPE melanosomes, Invest. Ophthalmol. Vis. Sci., 42, S755
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Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Fluorescence Lifetime Measurements and Biological Imaging
Berezin, M. Y., & Achilefu, S. (2010) · Chemical Reviews · doi:10.1021/cr900343z · Cited by 2,463
Nita, M., & Grzybowski, A. E. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3164734 · Cited by 1,510
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 650
Age-related macular degeneration (AMD): pathogenesis and therapy.
Nowak, J. Z. (2006) · PubMed · Cited by 607
Metadata
- Authors
- Sparrow, J. R., & Boulton, M.
- Affiliations
- Columbia University Irving Medical Center (US)
- Cardiff University (GB)
- Corresponding author
- Sparrow, Janet R.
- ORCID
- Sparrow, Janet R.
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 80
- Issue
- 5
- Pages
- 595-606
- ISSN
- 0014-4835 (ISSN-L)
- OpenAlex
- W1989558725
- Cited by
- 644
- References
- 162
- Citations by year
- 2026: 26 · 2025: 17 · 2024: 17 · 2023: 30 · 2022: 27 · 2021: 32 · 2020: 35 · 2019: 48 · 2018: 31 · 2017: 31 · 2016: 21 · 2015: 37 · 2014: 42 · 2013: 26 · 2012: 42
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY012951)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- lipofuscin, retinal pigment epithelium
- MeSH terms
- Aging, Humans, Light, Lipofuscin, Microscopy, Fluorescence, Oxidation-Reduction, Photoreceptor Cells, Pigment Epithelium of Eye, Pyridinium Compounds, Retinal Diseases, Retinoids, Vitamin A, Melanosomes
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