Cited by 645Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

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RPE lipofuscin and its role in retinal pathobiology

Sparrow, Janet R., Boulton, Mike·2005·Experimental Eye Research

DOI 10.1016/j.exer.2005.01.007

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Abstract

Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues.

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Dayhaw-Barker, 2001, The phototoxicity of aged RPE melanosomes, Invest. Ophthalmol. Vis. Sci., 42, S755

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Authors: Sparrow, J. R., & Boulton, M.
Affiliations: Columbia University Irving Medical Center (US)
Cardiff University (GB)
Corresponding author: Sparrow, Janet R.
ORCID: Sparrow, Janet R.
Venue: Experimental Eye Research
Publisher: Elsevier BV
Published: 2005-05
Volume: 80
Issue: 5
Pages: 595-606
ISSN: 0014-4835 (ISSN-L)
DOI: 10.1016/j.exer.2005.01.007
OpenAlex: W1989558725
Cited by: 644
References: 162
Citations by year: 2026: 26 · 2025: 17 · 2024: 17 · 2023: 30 · 2022: 27 · 2021: 32 · 2020: 35 · 2019: 48 · 2018: 31 · 2017: 31 · 2016: 21 · 2015: 37 · 2014: 42 · 2013: 26 · 2012: 42
FWCI: 6.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Eye Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (R01EY012951)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: lipofuscin, retinal pigment epithelium
MeSH terms: Aging, Humans, Light, Lipofuscin, Microscopy, Fluorescence, Oxidation-Reduction, Photoreceptor Cells, Pigment Epithelium of Eye, Pyridinium Compounds, Retinal Diseases, Retinoids, Vitamin A, Melanosomes

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RPE lipofuscin and its role in retinal pathobiology

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