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Intercapillary bridging cells: Immunocytochemical characteristics of cells that connect blood vessels in the retina

Mendes-Jorge, Luísa, Llombart, Cristina, Ramos, David, López-Luppo, Mariana, Valença, Andreia, Nacher, Victor, Navarro, Marc, Carretero, Ana, Méndez-Ferrer, Simón, Rodriguez-Baeza, Alfonso, Ruberte, Jesús·2012·Experimental Eye Research
DOI 10.1016/j.exer.2012.03.010
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Abstract

Intervascular bridges are fibrous strands that connect neighboring capillaries. These strands present associated cells, intervascular bridging cells (IBCs), whose nature and functional significance remains controversial. The aim of this study was to characterize the immunophenotype of IBCs, and contribute to understand their mechanical and intercellular communication properties in the retina. Quantification and retinal distribution of IBCs were also determined. For this purpose, C57BL/6N and nestin-GFP transgenic mice, as well as human retinas, were used. Whole-mount retinas were studied by means of immunohistochemistry and cytochemistry, and isolation of retinal vasculature was achieved by trypsin/pepsin digest technique. PAS reaction and the immunolabeling with anti-collagen IV and laminin antibodies revealed that IBCs were completely surrounded by a basement membrane, connecting two or more neighboring capillaries. IBCs were scarce and their number decreased with age. They were preferentially localized in the deep vascular plexus. In a murine model of experimental glaucoma, methylcellulose injected eyes showed retinal neovascularization and increased number of IBCs in the deep vascular plexus. IBCs were marked with anti-NG2, anti-PDGFR-β and anti-CD34 antibodies, and with tomato lectin, and were negative for PECAM-1. IBCs expressed nestin and filamentous actin, but desmin and α-smooth muscle actin were not detected. Moreover, these cells expressed the gap junction protein…

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Metadata

Authors
Mendes-Jorge, L., Llombart, C., Ramos, D., López-Luppo, M., Valença, A., Nacher, V., Navarro, M., Carretero, A., Méndez-Ferrer, S., Rodriguez-Baeza, A., & Ruberte, J.
Venue
Experimental Eye Research
Publisher
Elsevier BV
Published
2012-05
Volume
98
Pages
79-87
ISSN
0014-4835
DOI
10.1016/j.exer.2012.03.010
Cited by
30
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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