Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Open accessAbstract
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.
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Pericyte-endothelial interaction plays a key role in the establishment and maintenance of the BBB.
“Pericyte-endothelial interaction plays a key role in the establishment and maintenance of the BBB (27, 570, 648, 682).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [27]
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- Authors
- Armulik, A., Genové, G., & Betsholtz, C.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Betsholtz, Christer
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 21
- Issue
- 2
- Pages
- 193-215
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2073290778
- Cited by
- 2,653
- References
- 14
- Citations by year
- 2026: 154 · 2025: 189 · 2024: 181 · 2023: 194 · 2022: 214 · 2021: 234 · 2020: 244 · 2019: 186 · 2018: 187 · 2017: 205 · 2016: 178 · 2015: 153 · 2014: 132 · 2013: 124 · 2012: 60
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- pericytes, vascular morphogenesis, cardiovascular homeostasis, diabetic retinopathy, fibrosis, cancer therapy, mesenchymal stem cells, progenitor cells, adipocytes
- MeSH terms
- Animals, Cell Differentiation, Endothelium, Vascular, Models, Biological, Neovascularization, Pathologic, Signal Transduction, Neovascularization, Physiologic, Pericytes, Collagen Type IV
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