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Light-induced melatonin suppression: age-related reduction in response to short wavelength light
Abstract
One of the possible causes of disturbed circadian rhythms and sleep in the elderly may be impaired photic input to the circadian clock. Age-related changes in lens density are known to reduce the transmission of short wavelength light, which has been shown to be most effective in suppressing nocturnal melatonin. The aim of the study therefore was to investigate age-related changes in melatonin suppression in response to short and medium wavelength light. Young premenopausal (n=13) and postmenopausal (n=21) women were exposed to 30 min of monochromatic light at two different wavelengths and irradiances (lambda(max) 456 nm: 3.8 and 9.8 microW/cm(2); lambda(max) 548 nm: 28 and 62 microW/cm(2)). Melatonin suppression was compared across light treatments and between age groups. Significantly reduced melatonin suppression was noted in the elderly subjects following exposure to short wavelength (456 nm) light compared to the young subjects. These results are likely to reflect age-related changes in lens density.
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“Significantly reduced melatonin suppression was measured in the elderly subjects in response to exposure to blue (456 nm) light as compared to the young group.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [48]
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“This finding is suggested to reflect the age‐related changes in lens density.”
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“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
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Metadata
- Authors
- HERLJEVIC, M., MIDDLETON, B., THAPAN, K., & SKENE, D.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- SKENE, D
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 40
- Issue
- 3
- Pages
- 237-242
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2050381923
- Cited by
- 169
- References
- 32
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- melatonin suppression, short-wavelength light, circadian rhythm, aging, lens density, postmenopausal women, sleep disorders, light irradiance, nocturnal melatonin
- MeSH terms
- Adult, Female, Humans, Melatonin, Middle Aged, Radiation, Postmenopause, Area Under Curve
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