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Cited by 92Muscle Physiology and DisordersNutrition and Health in AgingGenetics, Aging, and Longevity in Model Organisms

Soleus and EDL muscle contractility across the lifespan of female C57BL/6 mice

Moran, Amy L., Warren, Gordon L., Lowe, Dawn A.·2005·Experimental Gerontology
DOI 10.1016/j.exger.2005.09.005
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Abstract

All previous aging research on the contractility of rodent skeletal muscle has been conducted on male rodents. Because males and females age differently, we undertook this study to determine if and when age-related decrements in skeletal muscle contractility occur in female mice. Soleus and extensor digitorum longus (EDL) muscles from female C57BL/6 mice aged approximately 4, 8, 16, 24 and 28 mo were assessed in vitro for contractility and subsequently contractile protein content. EDL muscle was resistant to age-related changes in force generation but displayed characteristics of becoming more slow-twitch like. Maximal isometric tetanic force (Po) generated by soleus muscle declined with age. Soleus muscle size and contractile protein contents were not affected by age and thus could not explain the age-related force decrements. Soleus muscle specific Po declined with age being approximately 26% lower in muscles of 16-28 mo-old mice indicating that a deterioration in soleus muscle quality of female mice occurred beginning around the age of ovarian failure. Thus this study provides essential, comprehensive baseline data for future studies on age-related muscle dysfunction in the female mouse.

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Crossref · 10.1016/j.exger.2005.09.005

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  • Loss of muscle performance has a greater negative impact on older adults than loss of muscle mass.

    “the preponderance of evidence from years indicates that loss of muscle performance has a greater negative impact on older adults than loss of mass [18, 20–25, 37–39].”

    From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [23]

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Authors
Moran, A. L., Warren, G. L., & Lowe, D. A.
Affiliations
  • University of Minnesota (US)
  • Georgia State University (US)
Corresponding author
Lowe, Dawn A.
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2005-12
Volume
40
Issue
12
Pages
966-975
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2005.09.005
OpenAlex
W2048802580
Cited by
92
References
51
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 11 · 2017: 2 · 2016: 2 · 2014: 7 · 2013: 2 · 2012: 4
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (K01AG020990, AG-20990)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32 AR-07612, T32AR007612)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
skeletal muscle aging, muscle contractility, soleus muscle, extensor digitorum longus, sex differences in aging, female mice, C57BL/6 mice, isometric tetanic force, contractile proteins, ovarian failure
MeSH terms
Aging, Animals, Biomechanical Phenomena, Hindlimb, Mice, Inbred C57BL, Muscle Contraction, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Mice

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