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Cited by 57Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

Evaluation of the applicability of HRT as a preservative of muscle strength in women

Meeuwsen, Ingrid B, Samson, Monique M, Verhaar, Harald J·2000·Maturitas
DOI 10.1016/s0378-5122(00)00132-8
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Abstract

Objectives To review the studies that have been undertaken on the effects of postmenopausal hormone replacement therapy (HRT); especially oestrogen (+progestin) regimens on the preservation of muscle strength. Current knowledge of the mechanisms and actions of steroid- and sex hormones on skeletal muscle tissue will be used in an attempt to clarify the mechanism of action of a possible effect. The objective is to arrive at an agreement on whether or not postmenopausal oestrogen administration has a positive influence on skeletal muscle tissue.Methods Peer-reviewed publications were assessed.Results An age-related decrement in muscle strength can be found in both men and women. However, in women, an extra decline can be observed around the time of menopause. A possible relationship between the additional diminution in muscle strength and altered hormone concentrations after the onset of menopause has been suggested. Since women nowadays spend one-third of their life postmenopausal, it is extremely important to keep the decline in muscle mass as small as possible. Besides the continuation of a physically active lifestyle, HRT was suggested to serve as a protective mechanism. Although, the usefulness of HRT as a preservative of muscle strength appeared controversial.Conclusions Skeletal muscle strength is sensitive to training up to a high age, though continuation of physical activity does not appear to protect skeletal muscles completely from age-related decrements. Therefore, the development of another preventive method would be useful. Considering the present knowledge it has all the hallmarks that HRT can be a useful tool in the maintenance of muscle strength in postmenopausal women. None the less, further research is necessary to endorse this theory.

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  • This decline in regenerative capacity is thought to be directly related to findings that estrogen is associated with maintenance of muscle strength in pre- and postmenopausal women and suggests a role for ERs in skeletal muscle maintenance.

    “This decline in regenerative capacity is thought to be directly related to findings that estrogen is associated with maintenance of muscle strength in pre- and postmenopausal women (69) and suggests a role for ERs in skeletal muscle maintenance (64, 84, 85, 88).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [64]

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Authors
Meeuwsen, I. B., Samson, M. M., & Verhaar, H. J.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Meeuwsen, Ingrid B
Venue
Maturitas
Publisher
Elsevier BV
Published
2000-07
Volume
36
Issue
1
Pages
49-61
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/s0378-5122(00)00132-8
OpenAlex
W2090050894
Cited by
57
References
116
Citations by year
2024: 2 · 2022: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
hormone replacement therapy, muscle strength, postmenopausal women, estrogen, progestins, skeletal muscle, menopause, age-related muscle loss, sex hormones, physical activity
MeSH terms
Aging, Female, Humans, Menopause, Ovariectomy, Muscle, Skeletal, Hormone Replacement Therapy

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