The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy
Abstract
Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural and genetic profile at the onset of heart failure has not been extensively studied. We therefore performed serial echocardiography, which allows repeated assessment of left ventricular (LV) function, on a cohort of the same mice every 3 months as they aged and demonstrated that LV systolic dysfunction becomes apparent at 18 months of age. These aging animals had left ventricular hypertrophy and fibrosis, but did not have inducible ventricular tachyarrhythmias. Gene expression profiling of left ventricular tissue demonstrated 40 differentially expressed probesets and 36 differentially expressed gene ontology terms, largely related to inflammation and immunity. At this early stage of cardiac dysfunction, we observed increased cardiomyocyte expression of the pro-apoptotic activated caspase-3, but no actual increase in apoptosis. The aging hearts also have higher levels of anti-apoptotic and autophagic factors, which may have rendered protection from apoptosis. In conclusion, we describe the functional, structural and genetic changes in murine hearts as they first develop cardiomyopathy of aging.
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“Age-dependent cardiac myopathy is typically observed by 18 months in mice and characterized by systolic dysfunction, left ventricle hypertrophy, and fibrosis (29).”
From Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction (2020) · cites this paper as [29]
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“the decline in contractility and the increases in hypertrophy and fibrosis are consistent with the extent of cardiac impairment that is observed in aging humans and animal models (29, 43).”
From Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction (2020) · cites this paper as [29]
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Autophagy in the Pathogenesis of Disease
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Physiology of cardiovascular aging
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Autophagy, organelles and ageing
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Autophagy in cardiac myocyte homeostasis, aging, and pathology
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Cited by
Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue
Boengler, K., Kosiol, M., Mayr, M., Schulz, R., & Rohrbach, S. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12178 · Cited by 421
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334
Autophagy in Cardiovascular Aging
Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239
Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135204 · Cited by 167
Zhou, J., Chong, S. Y., Lim, A., Singh, B. K., Sinha, R. A., Salmon, A. B., & Yen, P. M. (2017) · Aging · doi:10.18632/aging.101181 · Cited by 126
“However, the reports about the effects of aging on autophagy in skeletal and cardiac muscles are inconsistent as the autophagosome marker, LC3B-II, has been shown to increase [1, 2], decrease [3], or remain unchanged [4, 5], and have led to conflicting views on the role of autophagy in these tissues during aging.”
Background
Metadata
- Authors
- Boyle, A. J., Shih, H., Hwang, J., Ye, J., Lee, B., Zhang, Y., Kwon, D., Jun, K., Zheng, D., Sievers, R., Angeli, F., Yeghiazarians, Y., & Lee, R.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 46
- Issue
- 7
- Pages
- 549-559
- ISSN
- 0531-5565
- PMC
- PMC3104129
- Cited by
- 135
- References
- 40
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- Boyle, A. J., Shih, H., Hwang, J., Ye, J., Lee, B., Zhang, Y., Kwon, D., Jun, K., Zheng, D., Sievers, R., Angeli, F., Yeghiazarians, Y., & Lee, R. (2011). Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Experimental Gerontology. https://doi.org/10.1016/j.exger.2011.02.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
