Autophagy in Cardiovascular Aging

Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.

McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,112 · see citing works

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.052 · Cited by 3,791 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Ageing populations: the challenges ahead

Christensen, K., Doblhammer, G., Rau, R., & Vaupel, J. W. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61460-4 · Cited by 3,764 · see citing works

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works

ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008

Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,515 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart Association

Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208 · see citing works

Evidence for Cardiomyocyte Renewal in Humans

Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865 · see citing works

How to Interpret LC3 Immunoblotting

Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · cited 1× · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Hay, S. I., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32130-x · Cited by 2,083 · see citing works

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008 · see citing works

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

The intersection between aging and cardiovascular disease

North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works

Autophagy in mammalian development and differentiation

Mizushima, N., & Levine, B. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-823 · Cited by 1,555 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Autophagy modulation as a potential therapeutic target for diverse diseases

Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,358 · see citing works

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317 · see citing works

The tor pathway: a target for cancer therapy

Bjornsti, M., & Houghton, P. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1362 · Cited by 1,301 · see citing works

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · cited 1× · see citing works

Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble

Kontis, V., Bennett, J. E., Mathers, C. D., Li, G., Foreman, K. J., & Ezzati, M. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32381-9 · Cited by 1,221 · see citing works

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works

Impact of intermittent fasting on health and disease processes

Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187 · see citing works

Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works

Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000267723.65696.4a · Cited by 1,147 · see citing works

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057 · see citing works

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

Cárdenas, C., Miller, R. A., Smith, I., Bui, T., Molgó, J., Müller, M., Vais, H., Cheung, K.-H., Yang, J., Parker, I., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.007 · Cited by 1,026 · see citing works

Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)

Nishino, I., Fu, J., Tanji, K., Yamada, T., Shimojo, S., Koori, T., Mora, M., Riggs, J. E., Oh, S. J., Koga, Y., et al. (2000) · Nature · doi:10.1038/35022604 · Cited by 959 · see citing works

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E.-L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., & Saftig, P. (2000) · Nature · doi:10.1038/35022595 · Cited by 925 · see citing works

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Kitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921 · see citing works

Mouse Models in Aging Research

Flurkey, K., MCURRER, J., & HARRISON, D. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50074-1 · Cited by 904 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works

A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850 · see citing works

Autophagy and mitophagy in cardiovascular disease

Bravo-San Pedro, J. M., Kroemer, G., & Galluzzi, L. (2017) · Circulation Research · doi:10.1161/circresaha.117.311082 · Cited by 843 · cited 1× · see citing works

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842 · see citing works

Echocardiographically Detected Left Ventricular Hypertrophy: Prevalence and Risk Factors

Levy, D. A., Anderson, K. M., SAVAGE, D. D., Kannel, W. B., Christiansen, J. C., & Castelli, W. P. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-1-7 · Cited by 812 · see citing works

Caloric restriction

Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 769 · see citing works

Lifespan and healthspan: past, present, and promise

Crimmins, E. M. (2015) · The Gerontologist · doi:10.1093/geront/gnv130 · Cited by 762 · see citing works

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

Strait, J. B., & Lakatta, E. G. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.08.011 · Cited by 739 · see citing works

The mitochondrial‐lysosomal axis theory of aging

Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R. A., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.110.227371 · Cited by 688 · see citing works

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death &amp; Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Herranz, D., Muñoz-Martin, M., Cañamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., & Serrano, M. (2010) · Nature Communications · doi:10.1038/ncomms1001 · Cited by 612 · see citing works

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

Sarkar, S., Perlstein, E. O., Imarisio, S., Pineau, S., Cordenier, A., Maglathlin, R. L., Webster, J. A., Lewis, T. A., O’Kane, C. J., Schreiber, S. L., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio883 · Cited by 596 · see citing works

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works

Autophagy: machinery and regulation

Yin, Z., Pascual, C., & Klionsky, D. J. (2016) · Microbial Cell · doi:10.15698/mic2016.12.546 · Cited by 567 · see citing works

Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function

Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works

Endothelial aging

BRANDES, R., FLEMING, I., & BUSSE, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.027 · Cited by 563 · see citing works

Autophagy is required for glucose homeostasis and lung tumor maintenance

Karsli-Uzunbas, G., Guo, J. Y., Price, S., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0363 · Cited by 560 · see citing works

Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease

Antelmi, I., De Paula, R. S., Shinzato, A. R., Peres, C. A., Mansur, A. J., & Grupi, C. J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.065 · Cited by 555 · see citing works

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8700 · Cited by 553 · see citing works

Cytosolic lipolysis and lipophagy: two sides of the same coin

Zechner, R., Madeo, F., & Kratky, D. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.76 · Cited by 550 · see citing works

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Hafner, A. V., Dai, J., Gomes, A. P., Xiao, C., Palmeira, C. M., Rosenzweig, A., & Sinclair, D. A. (2010) · Aging · doi:10.18632/aging.100252 · Cited by 547 · see citing works

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., Ikeda, K., Ogata, T., & Matoba, S. (2013) · Nature Communications · doi:10.1038/ncomms3308 · Cited by 536 · see citing works

Effect of Aging and Physical Activity on Left Ventricular Compliance

Arbab-Zadeh, A., Dijk, E., Prasad, A., Fu, Q., Torres, P., Zhang, R., Thomas, J. D., Palmer, D., & Levine, B. D. (2004) · Circulation · doi:10.1161/01.cir.0000142863.71285.74 · Cited by 535 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

Heart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies

Sharma, K., & Kass, D. A. (2014) · Circulation Research · doi:10.1161/circresaha.115.302922 · Cited by 508 · see citing works

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Newman, J. C., Covarrubias, A. J., Zhao, M., Yu, X., Gut, P., Ng, C.-P., Huang, Y., Haldar, S., & Verdin, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.004 · Cited by 493 · see citing works

Mitochondrial oxidative stress in aging and healthspan

Dai, D., Chiao, Y. A., Marcinek, D. J., Szeto, H. H., & Rabinovitch, P. S. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-6 · Cited by 481 · see citing works

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

Wu, X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27374 · Cited by 479 · see citing works

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Sundaresan, N. R., Vasudevan, P., Zhong, L., Kim, G. H., Samant, S. A., Parekh, V., Pillai, V. B., Veeranna, R. P., Gupta, M., Jeevanandam, V., et al. (2012) · Nature Medicine · doi:10.1038/nm.2961 · Cited by 477 · see citing works

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

Kubli, D. A., Zhang, X., Lee, Y., Hanna, R. A., Quinsay, M. N., Nguyen, C. K., Jimenez, R., Petrosyan, S., Murphy, A. N., & Gustafsson, Å. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.411363 · Cited by 476 · see citing works

Essential role for autophagy in life span extension

Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works

Inhibition of autophagy in the heart induces age-related cardiomyopathy

Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., Mizote, I., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., et al. (2010) · Autophagy · doi:10.4161/auto.6.5.11947 · Cited by 450 · see citing works

Aging and Autophagy in the Heart

Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 443 · see citing works

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

Gong, G., Song, M., Csordás, G., Kelly, D. P., Matkovich, S. J., & Dorn, G. W. (2015) · Science · doi:10.1126/science.aad2459 · Cited by 441 · see citing works

Mitochondria and Cardiovascular Aging

Dai, D., Rabinovitch, P. S., & Ungvari, Z. I. (2012) · Circulation Research · doi:10.1161/circresaha.111.246140 · Cited by 435 · see citing works

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M., & Ouchi, Y. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.008 · Cited by 422 · see citing works

Insulin Signaling and Heart Failure

Riehle, C., & Abel, E. D. (2016) · Circulation Research · doi:10.1161/circresaha.116.306206 · Cited by 415 · see citing works

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

Maes, H., Kuchnio, A., Peric, A., Moens, S., Nys, K., Bock, K. D., Quaegebeur, A., Schoors, S., Γεωργιάδου, Μ., Wouters, J., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.06.025 · Cited by 411 · see citing works

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4267 · Cited by 389 · cited 1× · see citing works

Long-term caloric restriction ameliorates the decline in diastolic function in humans

Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.069 · Cited by 383 · see citing works

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

Kenyon, C. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0276 · Cited by 376 · see citing works

Rapamycin extends murine lifespan but has limited effects on aging

Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67674 · Cited by 374 · see citing works

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

Pietrocola, F., Lachkar, S., Enot, D. P., Niso-Santano, M., Bravo-San Pedro, J. M., Sica, V, Izzo, V, Maiuri, M. C., Madeo, F., Mariño, G., et al. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.215 · Cited by 357 · see citing works

Mitochondrial Metabolism in Aging Heart

Lesnefsky, E. J., Chen, Q., & Hoppel, C. L. (2016) · Circulation Research · doi:10.1161/circresaha.116.307505 · Cited by 350 · see citing works

Metformin slows down aging and extends life span of female SHR mice

Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Tyndyk, M. L., Yurova, M. V., Kovalenko, I. G., Poroshina, T. E., et al. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6625 · Cited by 348 · see citing works

Development of autophagy inducers in clinical medicine

Levine, B., Packer, M., & Codogno, P. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73938 · Cited by 344 · see citing works

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

Sinha, R. A., Farah, B. L., Singh, B. K., Siddique, M. M., Li, Y., Wu, Y., Ilkayeva, O., Gooding, J. R., Ching, J., Zhou, J., et al. (2013) · Hepatology · doi:10.1002/hep.26667 · Cited by 343 · see citing works

Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>

Jia, K., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.4989 · Cited by 341 · see citing works

Transcriptional and epigenetic regulation of autophagy in aging

Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 339 · see citing works

Autophagy-monitoring and autophagy-deficient mice

Kuma, A., Komatsu, M., & Mizushima, N. (2017) · Autophagy · doi:10.1080/15548627.2017.1343770 · Cited by 336 · see citing works

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331 · see citing works

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Wu, J., Liu, J., Chen, E. B., Wang, J., Cao, L., Narayan, N., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.030 · Cited by 328 · see citing works

Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart

Dai, D., Karunadharma, P. P., Chiao, Y. A., Basisty, N., Crispin, D. A., Hsieh, E. J., Chen, T., Gu, H., Djukovic, D., Raftery, D., et al. (2014) · Aging Cell · doi:10.1111/acel.12203 · Cited by 328 · see citing works

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

Saito, T., & Sadoshima, J. (2015) · Circulation Research · doi:10.1161/circresaha.116.303790 · Cited by 321 · see citing works

Late-life rapamycin treatment reverses age-related heart dysfunction

Flynn, J. M., O’Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12109 · Cited by 311 · see citing works

SRT1720 improves survival and healthspan of obese mice

Minor, R. K., Baur, J. A., Gomes, A. P., Ward, T. M., Csiszár, A., Mercken, E. M., Abdelmohsen, K., Shin, Y., Cantó, C., Scheibye‐Knudsen, M., et al. (2011) · Scientific Reports · doi:10.1038/srep00070 · Cited by 297 · see citing works

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293 · see citing works

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

Daitoku, H., Sakamaki, J.-I., & Fukamizu, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.03.001 · Cited by 285 · see citing works

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

Park, D., Jeong, H., Lee, M. N., Koh, A., Kwon, O., Yang, Y. R., Noh, J., Suh, P., Park, H., & Ryu, S. H. (2016) · Scientific Reports · doi:10.1038/srep21772 · Cited by 281 · see citing works

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

DeBosch, B. J., Heitmeier, M. R., Mayer, A. L., Higgins, C. B., Crowley, J. R., Kraft, T. E., Chi, M., Newberry, E. P., Chen, Z., Finck, B. N., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aac5472 · Cited by 280 · see citing works

Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling

Horn, M., & Trafford, A. W. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.005 · Cited by 273 · see citing works

Time-restricted feeding attenuates age-related cardiac decline in <i>Drosophila</i>

Gill, S., Le, H. D., Melkani, G. C., & Panda, S. (2015) · Science · doi:10.1126/science.1256682 · Cited by 272 · see citing works

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

Kajstura, J., Cheng, W. N., Ranganathan, S., Li, P., Li, B., Nitahara, J., Chapnick, S., Krzysztof Reiss, F., Olivetti, G., & Anversa, P. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.3.h1215 · Cited by 272 · see citing works

SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans

Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

Gurusamy, N., Lekli, I., Mukherjee, S., Ray, D., Ahsan, M. K., Gherghiceanu, M., Popescu, L. M., & Das, D. K. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp384 · Cited by 263 · see citing works

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

Eisenberg, T., Schroeder, S., Andryushkova, A., Pendl, T., Küttner, V., Bhukel, A., Mariño, G., Pietrocola, F., Harger, A., Zimmermann, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.010 · Cited by 256 · see citing works

Translational evidence that impaired autophagy contributes to arterial ageing

LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

Csiszár, A., Labinskyy, N., Jiménez, R., Pinto, J. T., Ballabh, P., Losonczy, G., Pearson, K. J., de Cabo, R., & Ungvari, Z. I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.004 · Cited by 248 · see citing works

Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.

Go, L. O., Moschella, M. C., Watras, J. M., Handa, K. K., Fyfe, B. S., & Marks, A. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117739 · Cited by 247 · see citing works

Impact of Lifelong Exercise “Dose” on Left Ventricular Compliance and Distensibility

Bhella, P. S., Hastings, J. L., Fujimoto, N., Shibata, S., Carrick‐Ranson, G., Palmer, M. D., Boyd, K. N., ADAMS-HUET, B. A., & Levine, B. D. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.062 · Cited by 247 · see citing works

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

Torisu, T., Torisu, K., Lee, I. H., Liu, J., Malide, D. A., Combs, C. A., Wu, X., Rovira, I. I., Fergusson, M. M., Weigert, R., et al. (2013) · Nature Medicine · doi:10.1038/nm.3288 · Cited by 246 · see citing works

The Impact of the Aging Population on Coronary Heart Disease in the United States

Odden, M. C., Coxson, P. G., Moran, A., Lightwood, J. M., Goldman, L., & Bibbins-Domingo, K. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.010 · Cited by 235 · see citing works

Long-Lived Growth Hormone Receptor Knockout Mice: Interaction of Reduced Insulin-Like Growth Factor I/Insulin Signaling and Caloric Restriction

Al-Regaiey, K., Masternak, M. M., Bonkowski, M. S., Sun, L. Y., & Bartke, A. (2004) · Endocrinology · doi:10.1210/en.2004-1120 · Cited by 235 · see citing works

Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevity

Milman, S., Atzmon, G., Huffman, D. M., Wan, J., Crandall, J. P., Cohen, P., & Barzilai, N. (2014) · Aging Cell · doi:10.1111/acel.12213 · Cited by 220 · see citing works

Mitochondrial Pruning by Nix and BNip3: An Essential Function for Cardiac-Expressed Death Factors

Dorn, G. W. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9174-x · Cited by 215 · see citing works

Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Santos‐Parker, J. R., Strahler, T. R., Bassett, C. J., Bispham, N. Z., Chonchol, M. B., & Seals, D. R. (2017) · Aging · doi:10.18632/aging.101149 · Cited by 214 · see citing works

The autophagy enhancer spermidine reverses arterial aging

LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S. R., An, S. S., Santhanam, L., Martin, B., Faulkner, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.018 · Cited by 206 · see citing works

Organelle-Specific Initiation of Autophagy

Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205 · see citing works

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

Sundaresan, N. R., Bindu, S., Pillai, V. B., Samant, S. A., Pan, Y., Huang, J.-Y., Gupta, M., Nagalingam, R. S., Wolfgeher, D. J., Verdin, E. M., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00586-15 · Cited by 205 · see citing works

Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

Hua, Y., Zhang, Y., Ceylan‐Isik, A. F., Wold, L. E., Nunn, J. M., & Ren, J. T. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0222-8 · Cited by 204 · see citing works

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

Gelino, S., Chang, J. T., Kumsta, C., She, X., Davis, A. E. M., Nguyen, C. N., Panowski, S. H., & Hansen, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006135 · Cited by 203 · see citing works

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

Li, Z., Song, Y., Liu, L., Hou, N., An, X., Zhan, D., Li, Y., Zhou, L., Li, P., Yu, L., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.95 · Cited by 192 · see citing works

Aging of myocardial collagen

de Souza, R. R. (2002) · Biogerontology · doi:10.1023/a:1021312027486 · Cited by 190 · see citing works

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K. L., Säftig, P., Marshall, C. A., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1368596 · Cited by 190 · see citing works

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

Gano, L. B., Donato, A. J., Pasha, H. M., Hearon, C. M., Sindler, A. L., & Seals, D. R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2014 · Cited by 188 · see citing works

Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction

Lam, C. S. P., Rienstra, M., Tay, W. T., Liu, L. C. Y., Hummel, Y. M., van der Meer, P., de Boer, R. A., Gelder, I. C. V., van Veldhuisen, D. J., Voors, A. A., et al. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.10.005 · Cited by 188 · see citing works

Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis

Roso, A. D. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00002-0 · Cited by 181 · see citing works

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

Yue, F., Li, W., Zou, J., Jiang, X., Xu, G., Huang, H. W., & Liu, L. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3462 · Cited by 176 · see citing works

Effects of 2‐year calorie restriction on circulating levels of IGF‐1, IGF‐binding proteins and cortisol in nonobese men and women: a randomized clinical trial

Fontana, L., Villareal, D. T., Das, S. K., Smith, S. R., Meydani, S. N., Pittas, A. G., Klein, S., Bhapkar, M. V., Rochon, J., Ravussin, É., et al. (2015) · Aging Cell · doi:10.1111/acel.12400 · Cited by 174 · see citing works

Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

Shinmura, K., Tamaki, K., Sano, M., Murata, M., Yamakawa, H., Ishida, H., & Fukuda, K. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.10.018 · Cited by 173 · see citing works

Fasting for weight loss: an effective strategy or latest dieting trend?

Johnstone, A. M. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.214 · Cited by 173 · see citing works

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works

GSK-3α is a central regulator of age-related pathologies in mice

Zhou, J., Freeman, T. A., Ahmad, F., Shang, X., Mangano, E. N., Gao, E., Farber, J. L., Wang, Y., Ma, X.-L., Woodgett, J. R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64398 · Cited by 167 · see citing works

Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways

Lesniewski, L. A., Seals, D. R., Walker, A. E., Henson, G. D., Blimline, M., Trott, D. W., Bosshardt, G. C., LaRocca, T. J., Lawson, B. R., Zigler, M. C., et al. (2016) · Aging Cell · doi:10.1111/acel.12524 · Cited by 167 · see citing works

Vascular aging: From molecular mechanism to clinical significance

Sawabe, M. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00603.x · Cited by 164 · see citing works

Local insulin‐like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice

Delaughter, M. C., Taffet, G. E., Fiorotto, M. L., Entman, M. L., & Schwartz, R. J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.1923 · Cited by 162 · see citing works

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

Wong, R. H. X., Berry, N. M., Coates, A. M., Buckley, J. D., Bryan, J., Kunz, I., & Howe, P. R. C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328362b9d6 · Cited by 162 · see citing works

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

Csiszár, A., Gautam, T., Sosnowska, D., Tarantini, S., Banki, E., Tucsek, Z., Tóth, P., Losonczy, G., Koller, Á., Reglődi, D., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00307.2014 · Cited by 161 · see citing works

The Role of Exercise in Cardiac Aging

Roh, J. D., Rhee, J., Chaudhari, V., & Rosenzweig, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.305250 · Cited by 160 · see citing works

Ins(1,4,5) <i> <i>P</i> </i> ₃ receptor-mediated Ca ²⁺ signaling and autophagy induction are interrelated

Decuypere, J.-P., Welkenhuyzen, K., Luyten, T., Ponsaerts, R., Dewaele, M., Molgó, J., Agostinis, P., Missiaen, L., De Smedt, H., Parys, J. B., et al. (2011) · Autophagy · doi:10.4161/auto.7.12.17909 · Cited by 159 · see citing works

Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works

Effects of Intermittent Feeding Upon Growth and Life Span in Rats

Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. L. (2009) · Gerontology · doi:10.1159/000212538 · Cited by 158 · see citing works

Mitochondria and oxidative stress in heart aging

Martín‐Fernández, B., & Gredilla, R. (2016) · AGE · doi:10.1007/s11357-016-9933-y · Cited by 155 · see citing works

Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy

Boyle, A., Shih, H., Hwang, J., Ye, J., Lee, B. K. H., Zhang, Y., Kwon, D., Jun, K., Zheng, D., Sievers, R., et al. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.02.010 · Cited by 153 · see citing works

Forecasted trends in disability and life expectancy in England and Wales up to 2025: a modelling study

Guzman-Castillo, M., Ahmadi‐Abhari, S., Bandosz, P., Capewell, S., Steptoe, A., Singh‐Manoux, A., Mika Kivimaki, B., Shipley, M. J., Brunner, E. J., & O’Flaherty, M. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30091-9 · Cited by 153 · see citing works

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

Morimoto, R. I., & Cuervo, A. M. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln071 · Cited by 151 · see citing works

Telomeres and Mitochondria in the Aging Heart

Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 150 · see citing works

The somatotropic axis in human aging: framework for the current state of knowledge and future research

Milman, S., Huffman, D. M., & Barzilai, N. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.014 · Cited by 150 · see citing works

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Csiszár, A., Labinskyy, N., Pérez, V., Recchia, F. A., Podlutsky, A. J., Mukhopadhyay, P., Losonczy, G., Pacher, P., Austad, S. N., Bartke, A., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.412.2008 · Cited by 148 · see citing works

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

Zaglia, T., Milan, G., Ruhs, A., Franzoso, M., Bertaggia, E., Pianca, N., Carpi, A., Carullo, P., Pesce, P., Sacerdoti, D., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66339 · Cited by 147 · see citing works

Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure

Campos, J. C., Queliconi, B. B., Bozi, L. H. M., Bechara, L. R. G., Dourado, P. M. M., Andres, A. M., Jannig, P. R., Gomes, K. M. S., Zambelli, V. O., Rocha-Resende, C., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1325062 · Cited by 146 · see citing works

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

Inuzuka, Y., Okuda, J., Kawashima, T., Kato, T., Niizuma, S., Tamaki, Y., Iwanaga, Y., Yoshida, Y., Kosugi, R., Watanabe-Maeda, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.871137 · Cited by 143 · see citing works

AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction

Turdi, S., Fan, X., Li, J., Zhao, J., Huff, A. F., Du, M., & Ren, J. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00586.x · Cited by 141 · see citing works

Aerobic exercise and other healthy lifestyle factors that influence vascular aging

Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works

Heart failure: when form fails to follow function

Katz, A. M., & Rolett, E. L. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv548 · Cited by 141 · see citing works

Autophagy is essential for cardiac morphogenesis during vertebrate development

Lee, E., Koo, Y., Ng, A., Wei, Y., Luby‐Phelps, K., Juraszek, A. L., Xavier, R. J., Cleaver, O. B., Levine, B., & Amatruda, J. F. (2014) · Autophagy · doi:10.4161/auto.27649 · Cited by 140 · see citing works

Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

Boulday, G., Rudini, N., Maddaluno, L., Blécon, A., Arnould, M., Gaudric, A., Chapon, F., Adams, R. H., Dejana, E., & Tournier‐Lasserve, E. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110571 · Cited by 138 · see citing works

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

Miller, B. F., Robinson, M. M., Bruss, M. D., Hellerstein, M. K., & Hamilton, K. L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00769.x · Cited by 137 · see citing works

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

Wang, C.-P., Lorenzo, C., Habib, S. L., Jo, B., & Espinoza, S. E. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.01.013 · Cited by 134 · see citing works

Does Longer Lifespan Mean Longer Healthspan?

Hansen, M., & Kennedy, B. K. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.002 · Cited by 130 · see citing works

Defective autophagy is a key feature of cerebral cavernous malformations

Marchi, S., Corricelli, M., Trapani, E., Bravi, L., Pittaro, A., Monache, S. D., Ferroni, L., Patergnani, S., Missiroli, S., Goitre, L., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505316 · Cited by 128 · see citing works

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Chiao, Y. A., Kolwicz, S. C., Basisty, N., Gagnidze, A., Zhang, J., Gu, H., Djukovic, D., Beyer, R. P., Raftery, D., MacCoss, M., et al. (2016) · Aging · doi:10.18632/aging.100881 · Cited by 128 · see citing works

Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

Yoshii, S. R., Kuma, A., Akashi, T., Hara, T., Yamamoto, A., Kurikawa, Y., Itakura, E., Tsukamoto, S., Shitara, H., Eishi, Y., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.001 · Cited by 127 · see citing works

New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart

Ikeda, Y., Sciarretta, S., Nagarajan, N., Rubattu, S., Volpe, M., Frati, G., & Sadoshima, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/210934 · Cited by 124 · see citing works

Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation

Ren, J. T., Yang, L., Zhu, L., Xu, X., Ceylan, A. F., Guo, W., Yang, J. Z., & Zhang, Y. (2017) · Aging Cell · doi:10.1111/acel.12616 · Cited by 122 · see citing works

The Essential Autophagy Gene ATG7 Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition

Singh, K. K., Lovren, F., Pan, Y., Quan, A., Ramadan, A., Matkar, P. N., Ehsan, M., Sandhu, P., Mantella, L. E., Gupta, N., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.604603 · Cited by 118 · see citing works

Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway

Pu, Y., Zhang, H., Wang, P., Zhao, Y. C., Li, Q., Wei, X., Cui, Y., Sun, J., Shang, Q., Liu, D., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354516 · Cited by 118 · see citing works

Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation

Castello, L., Froio, T., Maina, M., Cavallini, G., Biasi, F., Leonarduzzi, G., Donati, A., Bergamini, E., Poli, G., & Chiarpotto, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.003 · Cited by 114 · see citing works

This old heart: Cardiac aging and autophagy

Linton, P., Gurney, M. A., Sengstock, D. M., Mentzer, R. M., & Gottlieb, R. A. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.017 · Cited by 111 · see citing works

Atg13 Is Essential for Autophagy and Cardiac Development in Mice

Kaizuka, T., & Mizushima, N. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01005-15 · Cited by 106 · see citing works

Mitochondrial regulation of cell death: a phylogenetically conserved control

Galluzzi, L., Kepp, O., & Kroemer, G. (2016) · Microbial Cell · doi:10.15698/mic2016.03.483 · Cited by 106 · see citing works

Metabolic effects of fasting on human and mouse blood in vivo

Pietrocola, F., Demont, Y., Castoldi, F., Enot, D. P., Durand, S., Semeraro, M., Baracco, E. E., Pol, J. G., Pedro, J. M. B., Bordenave, C., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1271513 · Cited by 106 · see citing works

Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage

Li, Q., Wu, S., Li, S., Norby, F. L., Du, ‬., Kajstura, J., Anversa, P., & Ren, J. T. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01036.2006 · Cited by 103 · see citing works

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

Kwon, S., Seok, S., Yau, P. M., Li, X., KEMPER, B. W., & Kemper, J. K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.778720 · Cited by 102 · see citing works

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice

Ock, S., Lee, W. S., Ahn, J., Kim, H. M., Kang, H., Kim, H.-S., Jo, D., Abel, E. D., Lee, T. J., & Kim, J. (2015) · Endocrinology · doi:10.1210/en.2015-1709 · Cited by 101 · see citing works

Myocyte aging and mitochondrial turnover

Terman, A., & Brunk, U. T. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.005 · Cited by 100 · see citing works

Rapamycin Inhibits Cardiac Hypertrophy by Promoting Autophagy via the MEK/ERK/Beclin-1 Pathway

Gu, J. F., Hu, W. G., Song, Z., Chen, Y., Zhang, D., & Wang, C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00104 · Cited by 96 · see citing works

Alternate‐day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta‐analysis

Alhamdan, B. A., García-Álvarez, A., Alzahrnai, A. H., Karanxha, J., Stretchberry, D. R., Contrera, K. J., Utria, A. F., & Cheskin, L. J. (2016) · Obesity Science & Practice · doi:10.1002/osp4.52 · Cited by 95 · see citing works

Exercise and the Elderly

STAMFORD, B. A. (1988) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-198800160-00014 · Cited by 93 · see citing works

Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta

Zanetti, M., Cappellari, G. G., Burekovic, I., Barazzoni, R., Stebel, M., & Guarnieri, G. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.002 · Cited by 93 · see citing works

Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation

Yamada, J., Ohkusa, T., Nao, T., Ueyama, T., Yano, M., Kobayashi, S., Hamano, K., Esato, K., & Matsuzaki, M. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01144-5 · Cited by 92 · see citing works

RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity

Kawasaki, J., Aegerter, S., Fevurly, R. D., Mammoto, A., Mammoto, T., Şahin, M., Mably, J. D., Fishman, S. J., & Chan, J. C.-Y. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67084 · Cited by 92 · see citing works

Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats

Grigorian-Shamagian, L., Liu, W., Fereydooni, S., Middleton, R., Valle, J., Cho, J. H., & Marbán, E. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx454 · Cited by 92 · see citing works

Effects of calorie restriction on cardioprotection and cardiovascular health

Ahmet, I., Tae, H., de Cabo, R., Lakatta, E. G., & Talan, M. I. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.04.015 · Cited by 90 · see citing works

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Abdellatif, M., Trummer-Herbst, V., Heberle, A. M., Humnig, A., Pendl, T., Durand, S., Cerrato, G., Hofer, S. J., Islam, M., Voglhuber, J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059863 · Cited by 108 · see citing works

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109 · see citing works

The mitochondrial permeability transition: Nexus of aging, disease and longevity

Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works

Obesity accelerates cardiovascular ageing

Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73 · see citing works

Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function

Ruiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa132 · Cited by 67 · see citing works

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Thai, P. N., Seidlmayer, L. K., Miller, C., Ferrero, M., Dorn, G. W., Schaefer, S., Bers, D. M., & Dedkova, E. N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00382 · Cited by 66 · see citing works

Cardiovascular disease and the biology of aging

Moturi, S., Ghosh-Choudhary, S. K., & Finkel, T. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.04.005 · Cited by 56 · see citing works

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works

Spermidine ameliorates liver ischaemia-reperfusion injury through the regulation of autophagy by the AMPK-mTOR-ULK1 signalling pathway

Liu, H., Dong, J., Song, S., Zhao, Y., Wang, J., Fu, Z., & Yang, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.162 · Cited by 38 · see citing works

Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity

Louwagie, E. J., Larsen, T. D., Wachal, A. L., Gandy, T. C. T., Eclov, J. A., Rideout, T. C., Kern, K. A., Cain, J. T., Anderson, R. H., Mdaki, K. S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101746 · Cited by 20 · see citing works

Autophagy in cancer biology and therapy

Noor, N., Gammoh, Simon, 。., et al. (2014) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Is Selective Autophagy Distinct from Starvation-Induced Autophagy?

Guillebaud, G., & Germain, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00005-3

Death and survival of neuronal and astrocytic cells in ischemic brain injury： a role of autophagy

Min, Xü, Huiling, et al. (2011) · 中国药理学报：英文版 · Cited by 1 · see citing works

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older — China, 1998–2018

Zhou, J., Gao, X., Wei, Y., et al. (2023) · China CDC Weekly · doi:10.46234/ccdcw2023.005 · Cited by 2 · see citing works

Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26