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Cited by 135

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy

Boyle, Andrew J., Shih, Henry, Hwang, Joy, Ye, Jianqin, Lee, Brian, Zhang, Yan, Kwon, David, Jun, Kristine, Zheng, Daiwei, Sievers, Rich, Angeli, Franca, Yeghiazarians, Yerem, Lee, Randall·2011·Experimental Gerontology
DOI 10.1016/j.exger.2011.02.010PMC PMC3104129
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Abstract

Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural and genetic profile at the onset of heart failure has not been extensively studied. We therefore performed serial echocardiography, which allows repeated assessment of left ventricular (LV) function, on a cohort of the same mice every 3 months as they aged and demonstrated that LV systolic dysfunction becomes apparent at 18 months of age. These aging animals had left ventricular hypertrophy and fibrosis, but did not have inducible ventricular tachyarrhythmias. Gene expression profiling of left ventricular tissue demonstrated 40 differentially expressed probesets and 36 differentially expressed gene ontology terms, largely related to inflammation and immunity. At this early stage of cardiac dysfunction, we observed increased cardiomyocyte expression of the pro-apoptotic activated caspase-3, but no actual increase in apoptosis. The aging hearts also have higher levels of anti-apoptotic and autophagic factors, which may have rendered protection from apoptosis. In conclusion, we describe the functional, structural and genetic changes in murine hearts as they first develop cardiomyopathy of aging.

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Metadata

Authors
Boyle, A. J., Shih, H., Hwang, J., Ye, J., Lee, B., Zhang, Y., Kwon, D., Jun, K., Zheng, D., Sievers, R., Angeli, F., Yeghiazarians, Y., & Lee, R.
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2011-07
Volume
46
Issue
7
Pages
549-559
ISSN
0531-5565
DOI
10.1016/j.exger.2011.02.010
PMC
PMC3104129
Cited by
135
References
40
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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